07/13/2025
"These findings suggest that macronutrient composition in colostrum may adapt based on infant size at birth, even when gestational age is similar. Further research is needed to understand the implications for early infant feeding and metabolism."
Our bodies are amazing, we literally make milk that is exactly what our babies need, milk that is in fact perfect for our babies"
Although colostrum and mature milk are well studied, less is known about how colostrum composition varies across different birthweight categories in term infants.
This cross-sectional study (N = 252) compared colostrum collected on postpartum day 2 from individuals who delivered term infants classified as small (SGA), appropriate (AGA), or large (LGA) for gestational age.
Results showed:
🔹 Higher protein content in colostrum from the SGA and LGA groups compared to AGA
🔹 Higher carbohydrate content in the LGA group compared to AGA
🔹 No differences in fat or energy content
Multivariate analysis confirmed that SGA and LGA status were independently associated with higher protein levels, and LGA status was also associated with higher carbohydrate levels.
These findings suggest that macronutrient composition in colostrum may adapt based on infant size at birth, even when gestational age is similar. Further research is needed to understand the implications for early infant feeding and metabolism.
Citation: Arayici S, Alyamac Dizdar E, Kadioglu Simsek G, Sari FN. Relationship Between Birthweight for Gestational Age and Colostrum Macronutrient Composition: A Comparative Analysis in Small, Appropriate, and Large for Gestational Age Infants. Journal of Human Lactation. 2025;41(3):371-378. doi:10.1177/08903344251342561