Li Ka Shing Institute of Virology

Li Ka Shing Institute of Virology The page of Li Ka Shing Institute of Virology (LKSIoV) at the University of Alberta. Dr. D.
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The Li Ka Shing Institute of Virology (LKSIoV) unites a consortium of researchers to support discoveries in vaccines, treatments, and diagnostic tests for viral diseases affecting humans. Through leadership in scientific excellence & international collaboration, the Li Ka Shing Institute of Virology invests in virology and immunology research to discover new methods to prevent, treat, and cure vir

us-related disease to reduce the burden of viral disease around the world. The Institute builds on internationally recognized virology expertise and infrastructure with global connections to such partners as the US National Institutes of Health, the Bill and Melinda Gates Foundation and more. Lorne Tyrrell is the Founding Director of the Li Ka Shing Institute of Virology and a Distinguished University Professor at the University of Alberta. Dr. Tyrrell has received numerous prestigious awards for his studies on viral hepatitis. Since the COVID-19 pandemic, Dr. Tyrrell has worked on antivirals and vaccines for SARS-CoV-2. He is a member of the COVID-19 Vaccine Task Force that advises the Federal Government on the selection of COVID-19 vaccines based on efficacy, safety, and timely availability for Canada.

We're excited to be supporting these amazing six undergrads in their journey of science and discovery! Congrats, Isabell...
05/10/2023

We're excited to be supporting these amazing six undergrads in their journey of science and discovery! Congrats, Isabelle Bernard, Alisha Duggal, Levi Legaree, Eliana Pyon, Jessica Ramos, and Cole White. Read more about them https://www.ualberta.ca/li-ka-shing-institute-virology/research-training/awardees/undergraduate-summer-studentship-awardees.html Department of Medicine, University of Alberta, Women and Children's Health Research Institute University of Alberta Faculty of Graduate Studies & Research

Check out this recent pub by LKSIoV members Dr Carmen Charlton and Dr Graham Tipples: “A longitudinal seroepidemiology s...
05/10/2023

Check out this recent pub by LKSIoV members Dr Carmen Charlton and Dr Graham Tipples: “A longitudinal seroepidemiology study to evaluate antibody response to SARS-CoV-2 virus infection and vaccination in children in Calgary, Canada from July 2020 to April 2022: Alberta COVID-19 Childhood Cohort (AB3C) Study” https://pubmed.ncbi.nlm.nih.gov/37023007/ Faculty of Medicine & Dentistry - University of Alberta

In our population, after the first peak of Omicron variant infections and introduction of COVID-19 vaccines for children, all vaccinated children, but just over one-half of unvaccinated children, had SARS-CoV-2 spike antibodies indicating infection and/or vaccination, highlighting the benefit of vac...

Kudos to LKSIoV member Dr. Troy Baldwin, co-investigator of the pub “Destined for the intestine - thymic selection of TC...
05/08/2023

Kudos to LKSIoV member Dr. Troy Baldwin, co-investigator of the pub “Destined for the intestine - thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes.” https://pubmed.ncbi.nlm.nih.gov/37137518/ Faculty of Medicine & Dentistry - University of Alberta

The immune system is composed of a variety of different T cell lineages distributed through both secondary lymphoid tissue and non-lymphoid tissue. The intestinal epithelium is a critical barrier surface that contains numerous intraepithelial lymphocytes that aid in maintaining homeostasis at that b...

Congrats to LKSIoV member Dr. Bonita Lee on her pub “Trends in severe outcomes among adult and pediatric patients hospit...
05/04/2023

Congrats to LKSIoV member Dr. Bonita Lee on her pub “Trends in severe outcomes among adult and pediatric patients hospitalized with COVID-19 in the Canadian Nosocomial Infection Surveillance Program, March 2020 to May 2022.” https://pubmed.ncbi.nlm.nih.gov/37079304/ Department of Medicine, University of Alberta, Women and Children's Health Research Institute

The findings of this cohort study of patients hospitalized with laboratory-confirmed COVID-19 suggest that COVID-19 vaccination is important to reduce the burden on the Canadian health care system as well as severe outcomes associated with COVID-19.

Check out this pub by LKSIoV members Dr. Matthew Croxen and Dr. Gregory Tyrrell, “Genomic characterization of emerging i...
05/03/2023

Check out this pub by LKSIoV members Dr. Matthew Croxen and Dr. Gregory Tyrrell, “Genomic characterization of emerging invasive streptococcus agalactiae serotype VIII in Alberta, Canada.” https://pubmed.ncbi.nlm.nih.gov/37084119/ Faculty of Medicine & Dentistry - University of Alberta

Invasive Group B Streptococcus (GBS) can infect pregnant women, neonates, and older adults. Invasive GBS serotype VIII is infrequent in Alberta; however, cases have increased in recent years. Here, genomic analysis was used to characterize fourteen adult invasive serotype VIII isolates from 2009 to....

Kudos to LKSIoV member Dr. Michael Woodside on his pub “Mast cell proteases cleave prion proteins and a recombinant Ig a...
05/02/2023

Kudos to LKSIoV member Dr. Michael Woodside on his pub “Mast cell proteases cleave prion proteins and a recombinant Ig against PrP can activate human mast cells.”

IgE Abs, best known for their role in allergic reactions, have only rarely been used in immunotherapies. Nevertheless, they offer a potential alternative to the more commonly used IgGs. The affinity of IgE Ag binding influences the type of response from mast cells, so any immunotherapies using IgEs....

Check out this pub of LKSIoV members Dr David Evans and Dr Mary Hitt, "Radiation combined with oncolytic vaccinia virus ...
05/02/2023

Check out this pub of LKSIoV members Dr David Evans and Dr Mary Hitt, "Radiation combined with oncolytic vaccinia virus provides pronounced antitumor efficacy and induces immune protection in an aggressive glioblastoma model" https://pubmed.ncbi.nlm.nih.gov/37061120/ Faculty of Medicine & Dentistry - University of Alberta

Glioblastoma (GB) is a malignant and immune-suppressed brain cancer that remains incurable despite the current standard of care. Radiotherapy is a mainstay of GB treatment, however invasive cancer cells outside the irradiated field and radioresistance preclude complete eradication of GB cells. Oncol...

Congrats to LKSIoV member Dr. Carmen Charlton on her pub “Canadian SARS-CoV-2 serological survey using antenatal serum s...
05/01/2023

Congrats to LKSIoV member Dr. Carmen Charlton on her pub “Canadian SARS-CoV-2 serological survey using antenatal serum samples: a retrospective seroprevalence study.”

These results indicate widespread vulnerability to SARS-CoV-2 infection before vaccine availability in Canada. During the time periods sampled, public health tracking systems were under-reporting infections, and seroprevalence results during the Omicron period indicate extensive community spread of....

Kudos to LKSIoV members Dr. Xavier Clemente-Casares and Dr. Sue Tsai on their pub “Maternal provisions in type 1 diabete...
05/01/2023

Kudos to LKSIoV members Dr. Xavier Clemente-Casares and Dr. Sue Tsai on their pub “Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential.” https://pubmed.ncbi.nlm.nih.gov/37033940/ Faculty of Medicine & Dentistry - University of Alberta

Maternal influences on the immune health and development of an infant begin in utero and continue well into the postnatal period, shaping and educating the child's maturing immune system. Two maternal provisions include early microbial colonizers to initiate microbiota establishment and the t...

Check out LKSIoV member Dr. Lisa Willis’s recent pub “The sweet side of s*x as a biological variable.” https://pubmed.nc...
04/28/2023

Check out LKSIoV member Dr. Lisa Willis’s recent pub “The sweet side of s*x as a biological variable.” https://pubmed.ncbi.nlm.nih.gov/37021826/ University of Alberta Faculty of Science

Glycobiology as a field holds enormous potential for understanding human health and disease. However, few glycobiology studies adequately address the issue of s*x differences in biology, which severely limits the conclusions that can be drawn. Numerous CAZymes, lectins, and other carbohydrate-associ...

Congrats to LKSIoV member Dr. Bonita Lee on her pub “Antimicrobial use among paediatric inpatients at hospital sites wit...
04/27/2023

Congrats to LKSIoV member Dr. Bonita Lee on her pub “Antimicrobial use among paediatric inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program, 2017/2018.” https://pubmed.ncbi.nlm.nih.gov/37072874/ Women and Children's Health Research Institute

This study represents the largest collection of antimicrobial use data among hospitalized paediatric inpatients in Canada to date. In 2017/2018, overall AMU was 481 DOT/1000pd. National surveillance of AMU among paediatric inpatients is necessary for establishing benchmarks and informing antimicrobi...

XBB.1.16 is similar to XBB.1.5, the subvariant that's currently dominant in Alberta. As of Tuesday, XBB.1.5 accounted fo...
04/26/2023

XBB.1.16 is similar to XBB.1.5, the subvariant that's currently dominant in Alberta. As of Tuesday, XBB.1.5 accounted for 61 per cent of cases. Whereas XBB.1.16 accounts for up to 7% of coronavirus strains in the province.

As the SARS CoV-2 virus continues to evolve, yet another new subvariant has appeared in Alberta. XBB.1.16 is growing in prevalence in a number of countries, including India, where most cases have been detected so far.

Stop by this Thursday at noon to meet Dr. Warren Wakarchuk and hear his fascinating presentation. University of Alberta ...
04/25/2023

Stop by this Thursday at noon to meet Dr. Warren Wakarchuk and hear his fascinating presentation. University of Alberta Faculty of Science

Kudos to LKSIoV members Dr. Tom Hobman and Dr. Olivier Julien on their pub “Identification of human host substrates of t...
04/25/2023

Kudos to LKSIoV members Dr. Tom Hobman and Dr. Olivier Julien on their pub “Identification of human host substrates of the SARS-CoV-2 Mpro and PLpro using subtiligase N-terminomics.” https://pubmed.ncbi.nlm.nih.gov/37011043/ Faculty of Medicine & Dentistry - University of Alberta

The recent emergence of SARS-CoV-2 in the human population has caused a global pandemic. The virus encodes two proteases, Mpro and PLpro, that are thought to play key roles in the suppression of host protein synthesis and immune response evasion during infection. To identify th...

Check out LKSIoV member Dr. Shokrollah Elahi’s recent pub “Galectin-9 promotes natural killer cells activity via interac...
04/24/2023

Check out LKSIoV member Dr. Shokrollah Elahi’s recent pub “Galectin-9 promotes natural killer cells activity via interaction with CD44.” https://pubmed.ncbi.nlm.nih.gov/37006235/ UAlberta School of Dentistry, Faculty of Medicine & Dentistry - University of Alberta Cancer Research Institute of Northern Alberta - University of Alberta

Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules. Their effector functions are tightly synchronized by the balance between the stimulatory and inhibitory receptors. Here, we quantified the proportion of NK cells and the surface presence of Galectin-9 (Gal-9)...

Congrats to LKSIoV members Dr. Carmen Charlton and Dr. Graham Tipples on their pub “Retrospective testing for the presen...
04/21/2023

Congrats to LKSIoV members Dr. Carmen Charlton and Dr. Graham Tipples on their pub “Retrospective testing for the presence of monkeypox virus in a high-risk population from February-June 2022 in Alberta, Canada.” https://pubmed.ncbi.nlm.nih.gov/37008576/ Faculty of Medicine & Dentistry - University of Alberta

The results of this study indicate that circulation of MPXV in a higher-risk population in Alberta, prior to the first case, was less likely. We recommend that other provinces/territories review their local epidemiology, context and resources prior to conducting similar studies.

Join us next Thursday for this fascinating in person seminar by Dr. Warren Wakarchuk!   University of Alberta Faculty of...
04/21/2023

Join us next Thursday for this fascinating in person seminar by Dr. Warren Wakarchuk! University of Alberta Faculty of Science, Faculty of Medicine & Dentistry - University of Alberta

Kudos to LKSIoV member Dr. Trushar Patel on his pub “Investigating RNA-RNA interactions through computational and biophy...
04/20/2023

Kudos to LKSIoV member Dr. Trushar Patel on his pub “Investigating RNA-RNA interactions through computational and biophysical analysis.” https://pubmed.ncbi.nlm.nih.gov/36999609/ University of Lethbridge - Faculty of Arts & Science

Numerous viruses utilize essential long-range RNA-RNA genome interactions, specifically flaviviruses. Using Japanese encephalitis virus (JEV) as a model system, we computationally predicted and then biophysically validated and characterized its long-range RNA-RNA genomic interaction. Using multiple....

Check out LKSIoV member Dr. Jack Tuszynski ’s recent pub “Computational analysis and experimental testing of the molecul...
04/19/2023

Check out LKSIoV member Dr. Jack Tuszynski ’s recent pub “Computational analysis and experimental testing of the molecular mode of action of gatastatin and its derivatives.” https://pubmed.ncbi.nlm.nih.gov/36980600/ University of Alberta Physics Page

Given its critical role in cell mitosis, the tubulin γ chain represents a viable chemotherapeutic target to solve the specificity issues associated with targeting α and β tubulin. Since γ tubulin is overexpressed in glioblastoma multiforme (GBM) and some breast lesions, the glaziovianin A deriva...

Congrats to LKSIoV member Dr. Carla Coffin on her pub “Incidence of HIV and hepatitis C virus among people who inject dr...
04/18/2023

Congrats to LKSIoV member Dr. Carla Coffin on her pub “Incidence of HIV and hepatitis C virus among people who inject drugs, and associations with age and s*x or gender: a global systematic review and meta-analysis.” https://pubmed.ncbi.nlm.nih.gov/36996853/ University of Calgary's Cu***ng School of Medicine

Canadian Institutes of Health Research, Fonds de recherche du Québec-Santé, Canadian Network on Hepatitis C, UK National Institute for Health and Care Research, and WHO.

Kudos to LKSIoV member Dr. Sue Tsai on her pub “Regulation of the immune system by the insulin receptor in health and di...
04/17/2023

Kudos to LKSIoV member Dr. Sue Tsai on her pub “Regulation of the immune system by the insulin receptor in health and disease.” https://pubmed.ncbi.nlm.nih.gov/36992811/ Faculty of Medicine & Dentistry - University of Alberta

The signaling pathways downstream of the insulin receptor (InsR) are some of the most evolutionarily conserved pathways that regulate organism longevity and metabolism. InsR signaling is well characterized in metabolic tissues, such as liver, muscle, and fat, actively orchestrating cellular processe...

Check out LKSIoV members Dr. Gane Wong's and Dr. Jack Tuszynski’s recent pub “A molecular docking study reveals that sho...
04/17/2023

Check out LKSIoV members Dr. Gane Wong's and Dr. Jack Tuszynski’s recent pub “A molecular docking study reveals that short peptides induce conformational changes in the structure of human tubulin isotypes αβI, αβII, αβIII and αβIV.” https://pubmed.ncbi.nlm.nih.gov/36976059/ University of Alberta Physics Page

Microtubules are cylindrical protein polymers assembled in the cytoplasm of all eukaryotic cells by polymerization of aβ tubulin dimers, which are involved in cell division, migration, signaling, and intracellular traffic. These functions make them essential in the proliferation of cancerous cells ...

Congrats to LKSIoV member Dr. Andrew Mason on his pub “Modeling primary biliary cholangitis and primary sclerosing chola...
04/14/2023

Congrats to LKSIoV member Dr. Andrew Mason on his pub “Modeling primary biliary cholangitis and primary sclerosing cholangitis as infectious diseases.” https://www.sciencedirect.com/science/article/pii/B9780323853897000168 Faculty of Medicine & Dentistry - University of Alberta, Department of Medicine, University of Alberta

The cholangiopathies, primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are idiopathic and complex cholestatic disorders cha…

Kudos to LKSIoV members Dr. Matthew Croxen and Dr. David Evans on their pub “Patient and ward related risk factors in a ...
04/13/2023

Kudos to LKSIoV members Dr. Matthew Croxen and Dr. David Evans on their pub “Patient and ward related risk factors in a multi-ward nosocomial outbreak of COVID-19: Outbreak investigation and matched case-control study.” https://pubmed.ncbi.nlm.nih.gov/36949510/ Faculty of Medicine & Dentistry - University of Alberta

Transmission routes of SARS-CoV-2 in hospital outbreaks are complex; however multi-bedded rooms play a significant role in the transmission of SARS-CoV-2.

Check out LKSIoV member Dr. Andrew Mason’s recent pub “HERV1-env induces unfolded protein response activation in autoimm...
04/04/2023

Check out LKSIoV member Dr. Andrew Mason’s recent pub “HERV1-env induces unfolded protein response activation in autoimmune liver disease: a potential mechanism for regulatory T cell dysfunction." https://journals.aai.org/jimmunol/article/210/6/732/237816 Department of Medicine, University of Alberta

Key Points. The liver microenvironment in AIH and dnAIH is enriched with HERV1-env.HERV1-env induced loss of Treg suppressor function in dnAIH.Our results, to o

Congrats to LKSIoV member Dr. Carmen Charlton  on her pub “What's in a number? The value of titers as routine proof of i...
04/03/2023

Congrats to LKSIoV member Dr. Carmen Charlton on her pub “What's in a number? The value of titers as routine proof of immunity for medical students.” https://pubmed.ncbi.nlm.nih.gov/36948982/ Faculty of Medicine & Dentistry - University of Alberta

The requirement of numerical, non-standardized serologic testing highlights an oversight in medical school admissions documentation. The requirement for quantitative values to demonstrate immunity is not practical from a laboratory standpoint, and is not needed to show individual immunity to these v...

Kudos to LKSIoV member Dr. Michael Woodside on his pub “Mast cell proteases cleave prion proteins and a recombinant Ig a...
03/31/2023

Kudos to LKSIoV member Dr. Michael Woodside on his pub “Mast cell proteases cleave prion proteins and a recombinant Ig against PrP can activate human mast cells.” https://pubmed.ncbi.nlm.nih.gov/36939393/ University of Alberta Physics Page

IgE Abs, best known for their role in allergic reactions, have only rarely been used in immunotherapies. Nevertheless, they offer a potential alternative to the more commonly used IgGs. The affinity of IgE Ag binding influences the type of response from mast cells, so any immunotherapies using IgEs....

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6010 Katz Centre For Health Research
Edmonton, AB
T6G2E1

Opening Hours

Monday 8:30am - 4:30pm
Tuesday 8:30am - 4:30pm
Wednesday 8:30am - 4:30pm
Thursday 8:30am - 4:30pm
Friday 8:30am - 4:30pm

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+17804921084

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