03/09/2026
Wintergreen EO demonstrated significant anti-inflammatory activity comparable to the NSAID diclofenac sodium in laboratory research. Given that methyl salicylate is a salicylate derivative with known COX-inhibitory and counterirritant properties, the findings provide biochemical validation for the plant’s traditional use in musculoskeletal and inflammatory pain conditions. The measurable protein-stabilizing effect observed suggest potential to use wintergreen EO for topical management of human inflammatory conditions such as arthritis, myalgia, and neuralgia, warranting further evaluation.
https://abstracts.aijr.org/index.php/abs/article/view/186/117