QAnxiety

05/22/2026

AI cannot replace your therapist!

Currently, there are many different types of AI that will chat with you, but most of them will do more harm than good to your mental health. AI companions and chatbots are not designed to improve people's mental health, they are designed to increase engagement, and they can be really effective. AI companies are being sued left and right because of people dying because of their chatbots.

Only a very thin slice of all AI chatbots are actually designed to help people to improve their mental health. These are still in development phase. After being developed they must be tested in clinical trials. Clinical trials will show how safe and effective they are, and only then regulatory agencies (Health Canada, FDA, etc.) will make their assessment and approve them (or not).

If we wait for medications to be approved by Health Canada before taking them, why would we risk our mental health by using unregulated AI chatbots?

Companion chatbots and clinical chatbots are different products. We are treating them as the same thing.

05/01/2026

Happy National Physician's Day!

Thank you for all the hard work you do to keep patients safe, healthy and happy.

04/21/2026

Recently published review: Does the Menstrual Cycle Affect OCD Symptoms?

Emerging evidence suggests that hormonal changes across the menstrual cycle may influence symptoms of obsessive-compulsive and related disorders (OCRDs), but the research base remains limited.
In a recent scoping review, Mojgani et al. synthesized existing studies examining how OCRD symptoms fluctuate across the menstrual cycle.
Across 12 studies (primarily focused on OCD) participants reported worsening symptoms during the premenstrual (luteal) phase.

Despite these preliminary findings the authors noted the lack of research in this area:
- Most studies relied on retrospective self-report
- Only one study used longitudinal symptom measurement
- Very few studies examined OCRDs beyond OCD

These findings highlight an important gap in psychiatric research. Understanding how female s*x hormones may influence OCD symptoms could have implications for both assessment and treatment, particularly for individuals who experience cyclical symptom changes.

For more information see the article below:

This link will take you to a page that’s not on LinkedIn

04/11/2026

New Research for Treatment-Resistant Depression using inhaled psychedelics:

A recent Phase 2 clinical trial has found encouraging results for a new inhalable psychedelic treatment for people with treatment-resistant depression.

The study tested GH001, an inhalable formulation of the psychedelic compound 5‑MeO‑DMT. This naturally occurring substance is known for producing intense but very short-lasting psychedelic experiences.

Researchers at 16 clinical sites across Europe enrolled 81 adults with treatment-resistant depression, on average participants had been experiencing depression for about 12 years and had not responded to at least two previous antidepressant treatments.

Here’s what they found:

- Major symptom reduction: Average depression scores dropped from moderate/severe levels to much milder symptoms.

- 57% of patients receiving the drug were in remission after 8 days, compared to 0% in the placebo group.

- Short-acting experience: The psychoactive effects lasted only about 9–14 minutes, allowing patients to recover quickly and be discharged the same day.

- Many patients who initially improved were able to maintain remission with occasional maintenance treatments over six months.

While larger studies are still needed, these early findings suggest that fast-acting psychedelic therapies, especially short-duration ones like inhaled 5-MeO-DMT, may represent a new frontier in treating severe depression.

For more information see the article below:

03/27/2026

A new Canadian study out of McMaster University (Halladay et al. 2026) highlights a concerning shift in the relationship between cannabis use and mental health over the past decade.

Researchers analyzed two nationally representative surveys from 2012 (n=25,113) and 2022 (n=9,861) examining cannabis use and internalizing mental health conditions among Canadians aged 15+. The findings show significant changes in both prevalence and strength of association.

Key findings:
• The prevalence of generalized anxiety disorder (GAD), major depressive episodes (MDE), and cannabis use roughly doubled between 2012 and 2022
• Suicidality rates remained stable overall, but increased by 44% among youth
• More frequent cannabis use was linked to higher rates of anxiety, depression, and suicidality, with a clear dose-response relationship.

These findings highlight the importance of early identification, prevention, and integrated mental health and substance use care, especially as cannabis use patterns continue to evolve post cannabis legalization and post-pandemic.

For more information see the article below:

Objective As epidemiological patterns of cannabis use and internalizing problems evolve globally, it is critical to reassess their associations—particularly in ...

02/25/2026

Presenting new research on treatments for anxiety disorders, OCD and PTSD in the 36th Annual Therapeutics Queen's University Faculty of Health Sciences

02/13/2026

New research from the Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education at the University of Calgary suggests we may be able to detect neural markers of depression and anxiety before symptoms begin in high-risk adolescents.

In a longitudinal study of youth ages 11 to 17 with a family history of internalizing disorders, researchers examined resting-state functional connectivity (RSFC) using baseline brain scans. Participants had no prior clinically significant episodes at study entry and were followed for 18 months to track new onset of depression or anxiety.

Key finding: Adolescents who later developed depression or anxiety already showed distinct patterns of altered connectivity at baseline, particularly in subcortical regions involved in emotion and reward processing, including striatal and limbic circuits, and their connections with parietal and visual regions.
Importantly, these differences were present before clinical onset and remained significant after controlling for age, s*x, and subclinical symptoms, suggesting altered striatal connectivity may serve as a pre-morbid biomarker.
If replicated in larger and more diverse samples, these findings could
• Improve early identification of high-risk youth
• Inform targeted prevention strategies
• Help refine interventions, including behavioral therapies and neuromodulation approaches

For more info see:

01/22/2026

New International OCD Treatment Guidelines (2025) have been published!

The Canadian Network for Mood and Anxiety Treatments (CANMAT), in collaboration with the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS), has released the 2025 International Guidelines for the Management of Obsessive-Compulsive Disorder.

Developed by a global panel of OCD experts and informed by systematic literature reviews, expert consensus, and lived-experience feedback, these guidelines provide clear, practical, and evidence-based recommendations for OCD care across the lifespan.

These guidelines include:
- Foundations of OCD diagnosis and management
- Psychological, pharmacological, and neuromodulation treatments
- Approaches to treatment resistant OCD
- Pediatric and adolescent OCD
- OCD in special populations and future directions

Recommendations are organized by levels of evidence and summarized in accessible tables, making them especially useful for day-to-day clinical decision-making. For more information see the article below:

01/22/2026

Can music-based digital therapeutics help reduce anxiety?

In a randomized study of individuals with moderate anxiety already taking medication, music combined with auditory beat stimulation (ABS) significantly reduced anxiety and negative affect compared to a pink noise control. Importantly, longer listening times led to greater improvements, suggesting a dose–response effect, with the strongest reductions seen after 36 minutes of exposure.

With over 1,300 participants screened and 144 randomized, these findings replicate earlier evidence that music with ABS may provide acute anxiety relief, especially when access to traditional treatments like CBT is limited due to cost, time, or availability.

For more information, see the full study below:

Anxiety is one of the most frequently reported mental health conditions worldwide, yet access to effective treatments such as medication and cognitive behavioral therapy (CBT) remains limited due to cost, time, and potential side effects. Music-based digital therapeutics, particularly when combined....

12/29/2025

OCD or an Anxiety Disorder? Getting the Diagnosis Right:

In this video interview Dr. Jesse M. Crosby shares what you should know about OCD and common anxiety disorders, answering questions to help clinicians, educators, and loved ones recognize the difference between naturally occurring anxiety, potentially debilitating anxiety disorders, and OCD. He explores the keys to their accurate diagnoses and answers audience questions about treatment approaches.

Link to the video:

Watch McLean videos and webinars on demand including OCD or an Anxiety Disorder? Getting the Diagnosis Right