Cannabis Science Information

05/14/2025

Highlights

•The Endocannabinoid System (ECS) is a physiological system essential for maintaining CNS homeostasis and regulating neurological functions.

•ECS and cannabinoid receptors (CBRs) play a crucial role in several neurological disorders.

•The cannabinoid type 2 receptor (CB2R) is a promising therapeutic target due to its neuroprotective effects without CB1R-related psychotropic effects.

•Although the effects of CB2R agonists are numerous, clinical studies conducted to date are still limited.

05/14/2025

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Results: The meta-analysis revealed a significant consensus supporting the use of medical cannabis in the categories of health metrics, cancer treatments, and cancer dynamics. The aggregated correlation strength of cannabis across all cancer topics indicates that support for medical cannabis is 31.38× stronger than opposition to it. The analysis highlighted the anti-inflammatory potential of cannabis, its use in managing cancer-related symptoms such as pain, nausea, and appetite loss, and explored the consensus on its use as an anticarcinogenic agent.
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Background: Growing bodies of evidence suggest that cannabis may play a significant role in both oncological palliative care and as a direct anticarcinogenic agent, but classification as a Schedule I substance has complicated research into its therapeutic potential, leaving the state of research sca...

10/21/2024

https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1309167/full

Discoid lupus erythematosus (DLE) is a common autoimmune skin disease in dogs. Conventional treatments, such as corticosteroids, can be effective but often h...

10/10/2024

Objective science is finally catching up to what many have known for decades!

For centuries, cannabinoids have been utilized for their medicinal properties, particularly in Asian and South-Asian countries. Cannabis plants, known for their psychoactive and non-psychoactive potential, were historically used for spiritual and remedial healing. However, as cannabis became predomi...

09/18/2023

https://www.psychiatrist.com/jcp/neurologic/dementia/dispensary-obtained-tetrahydrocannabinol-treatment-neuropsychiatric-symptoms-dementia/

Neuropsychiatric symptoms (NPS) in dementia are challenging to manage, and available treatments have a significant side effect profile. This study evaluated the effectiveness of dispensary-obtained tetrahydrocannabinol for patients with dementia and NPS.

08/29/2023

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Samples taken 5 days after THC treatment showed significant differential expression of genes associated with neurogenesis and brain development. In samples taken 5 weeks after treatment, the transcriptional signature was shifted to that of neuronal differentiation and survival. This study demonstrated the use of hippocampal transcriptome profiling in uncovering the molecular basis of the atypical, anti-aging effects of THC microdose treatment in old mice.
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Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system. In previous studies, we demonstrated that a single microdose of THC (0.002 mg/kg, 3–4 orders of magnitude lower than the standard dose for rodents)...

08/22/2023

08/22/2023

THIS IS NOT CANNABINOID THERAPY!! This study is brutally flawed due to the selective criteria of only using studies involving SYNTHETIC CANNABIBIOIDS!!!

The erroneous use of SYNTHETICS discounts ANY AND ALL of the study conclusions since this is NOT TRUE CANNABIS TREATMENT!


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The active treatments used in these studies included two main cannabinoids in ma*****na, delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD), and the prescription drugs nabilone (Cesamet), dronabinol (Marinol, Syndros), and nabiximols (Sativex).
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Treating pain is the most common reason offered by the millions of Americans who use products that contain cannabinoids. However, there's good evidence that a placebo provides very similar p...

08/21/2023

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The present study tracked cannabis usage over a 2-year period and examined its associations with clinical and neurocognitive outcomes, along with medication rates. CHR youth who continuously used cannabis had higher neurocognition and social functioning over time, and decreased medication usage, relative to non-users. Surprisingly, clinical symptoms improved over time despite the medication decreases.
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Recreational cannabis use has recently gained considerable interest as an environmental risk factor that triggers the onset of psychosis. To date, how…

08/19/2023

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Conclusions: Formulations of cannabis significantly improved anxiety, depression, fatigue, and the ability to participate in social activities in participants with anxiety disorders. The AEs experienced by participants are consistent with those in other studies.
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Background: Anxiety is a condition for which current treatments are often limited by adverse events (AEs). Components of medicinal cannabis, cannabidiol (CBD) a...