09/24/2025
The Gut & Immune Connection: Allergies, Skin Health & Autoimmunity
Your gut doesn’t just digest food—it trains your immune system.
About 70–80% of immune cells live in or around the gut, making it the body’s largest immune organ.
When the gut is disrupted (through inflammation or dysbiosis), the immune system can become overactive, confused, or hypersensitive—leading to:
🔹 Skin rashes or hives
🔹 Allergies or food sensitivities
🔹 Autoimmune diseases
🔹 Chronic inflammation
1. Gut as Gatekeeper
A healthy gut lining allows nutrients to enter and prevents invaders from entering. A balanced microbiome:
✔️ Trains immune tolerance
✔️ Suppresses inflammation
✔️ Supports anti-autoimmune compounds (SCFAs)
2. Dysbiosis = Immune Overactivation
When gut bacteria are imbalanced, the immune system may start:
⚠️ Attacking safe proteins (like food or self-tissues)
⚠️ Overproducing histamine (linked to hives/allergies)
⚠️ Triggering widespread inflammation
3. Gut-Immune-Skin Axis
Leaky gut allows microbes and food particles into the bloodstream → immune activation → skin flare-ups like eczema, psoriasis, rosacea, and chronic itching.
4. Autoimmune Link
🧬 A 2024 review (Autoimmune Rev) found that gut dysbiosis patterns were common across 7 autoimmune diseases—including RA, SLE, AS & Sjögren’s.
Disrupted gut microbes can damage the intestinal lining, trigger immune responses, and—via antigen mimicry—lead immune cells to attack healthy tissue.
Click the link below to learn more about Dr. James Yoon.
https://bit.ly/4pEHxcm
References
1. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014 Mar 27;157(1):121–41. doi: 10.1016/j.cell.2014.03.011
2. Wang H, Cai Y, Wu W, Zhang M, Dai Y, Wang Q. Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review. Autoimmun Rev. 2024 Dec;23(12):103654. doi: 10.1016/j.autrev.2024.103654