10/18/2025
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In a groundbreaking discovery, scientists have identified a powerful anti-aging enzyme that acts like “DNA glue,” repairing damage inside our cells and potentially reversing the effects of aging at the molecular level.
This enzyme, known as poly (ADP-ribose) polymerase 1, or PARP1, plays a critical role in maintaining the integrity of our DNA. Every day, our cells are bombarded by toxins, stress, radiation, and other factors that cause DNA to break or unravel. Left unrepaired, these breaks accelerate aging, trigger inflammation, and lead to diseases like cancer, dementia, and organ failure.
But PARP1 works like a cellular repair crew — it detects DNA damage and seals the breaks, restoring the genetic blueprint before mutations take hold. Scientists describe it as acting like molecular glue, binding broken DNA strands back together with astonishing speed and accuracy.
As we age, PARP1 activity naturally declines, allowing damage to accumulate. But new studies show that boosting this enzyme’s activity — either through targeted compounds, gene therapies, or lifestyle factors — could delay aging, improve cell regeneration, and extend healthspan.
Some experiments have already shown promising results in lab animals, including improved brain function, stronger immunity, and reduced age-related cell decline. Researchers are now racing to explore how PARP1 could be enhanced safely in humans.
This discovery doesn’t just target symptoms of aging — it addresses the root cause by helping cells self-repair from the inside out. It could be a key turning point in the quest to slow or even reverse biological aging.