12/25/2025
A remarkable new study shows that a single high-equivalent dose of psilocybin in mice can rapidly increase neuroplasticity by repairing and creating new neural connections in the brain. Researchers observed structural remodeling of dendritic spines in the medial frontal cortex, effectively rewiring neural networks. (As seen in this Cell.com article: https://www.cell.com/cell/fulltext/S0092-8674(25)01305-4) These changes were network-specific, strengthening pathways tied to perception and the brain’s default mode network, while quieting repetitive cortical loops. This work deepens our understanding of how psilocybin may support mental health by reshaping large-scale brain connectivity.
Watch the video by Chase Hughes to learn more: https://www.youtube.com/watch?v=lZ3_GUilpnk
