
08/09/2025
Feature summary
Regenerlife UniqueRelief IBS Butyric Acid provides an easily absorbed form of this short-chain fatty acid (SCFA)
to help relieve abdominal pain and discomfort associated with irritable bowel syndrome (IBS). Butyric acid
is naturally produced in the gut by beneficial bacteria during the fermentation of dietary fibre. It serves
as a primary energy source for intestinal cells within the gut lining. Maintaining the integrity of this lining plays
a key role in overall gut health and microbiome balance. Sodium butyrate is considered the preferred form
of butyric acid for supplementation. This is because it has greater bioavailability and is easier for the body
to absorb and transport to the colon, where it exerts its beneficial effects.
UniqueRelief is part of the Regenerlife healthy-aging line of supplements. Each packet contains four softgels,
providing a total dose of 1000 mg of butyric acid. It is non-GMO, gluten-free, and a fantastic supplement for aging
adults with IBS.
How it works
Epithelial cells in the large intestine (colon) primarily rely on SCFAs, especially butyric acid, as their main energy
source. Once absorbed into the epithelial cells, butyric acid is taken up by the mitochondria, where it is converted
into adenosine triphosphate (ATP). This ATP fuels essential cellular functions, such as the absorption of water,
electrolytes, and nutrients, while also helping to maintain the integrity of the gut barrier (Hodgkinson et al., 2023).
Butyric acid also supports colon health by regulating blood flow to the intestinal lining, intestinal motility, and
pH levels (Facchin et al., 2020). It helps protect the gut lining from damage and promotes healing by regulating
genes involved in cell renewal. Butyric acid strengthens the gut barrier by enhancing tight junction proteins, which
seal gaps between cells. Additionally, it stimulates mucus production, creating a protective layer that prevents
harmful substances from entering the bloodstream (Hodgkinson et al., 2023).
Butyric acid enhances oxygen utilization in gut cells, creating a low-oxygen environment that supports gut health
and promotes a more balanced gut microbiome. It also upregulates the synthesis of antimicrobial proteins that
help protect against pathogens (Hodgkinson et al., 2023).
Butyric acid interacts with receptors on colon and immune system cells, triggering changes in the levels of certain
immune signals (cytokines) and activating anti-inflammatory signalling pathways (Hodgkinson et al., 2023).