10/25/2025
⚠️ Fentanyl-stimulant overdoses among seniors have surged 9,000%. The opioid crisis is no longer just a young person’s issue.
A devastating new analysis has revealed a 9,000% surge in fentanyl-related overdose deaths among Americans aged 65 and older, especially when mixed with stimulants like co***ne and methamphetamine.
The findings, presented at the ANESTHESIOLOGY 2025 conference, mark a shocking shift in the opioid epidemic, which has now entered its fourth wave—dominated by deadly combinations of fentanyl and stimulants. Once considered a crisis for younger adults, the data show older Americans are increasingly affected, with 50% of fentanyl deaths in this age group now involving stimulants, compared to just 9% in 2015.
This alarming trend highlights how age-related factors—like chronic conditions, slower drug metabolism, and multiple medications—can amplify overdose risk. Researchers urge clinicians to recognize that polysubstance use affects all age groups and to use extra caution when prescribing opioids to seniors. Strategies such as reducing unnecessary opioid use, involving caregivers in harm reduction, and screening broadly for substance use could help curb this deadly spike. As overdose patterns evolve, experts warn that prevention efforts must also shift to include older adults in education, screening, and intervention.
source
Presented at the ANESTHESIOLOGY 2025 annual meeting, analysis based on CDC WONDER data, 1999–2023.