Geneyouin

12/10/2024

A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor https://buff.ly/49usUAM Another study linking cholesterol to elevated risk of cancer. Statins reduce the risk of mortality, including cancer

Many people don’t like taking statins because of side effects. Yet statins are essential to reduce your risk of heart disease and they can also reduce your risk of cancer. Understanding your genetic profile can help optimize statin selection and dosage to minimize side effects.

12/09/2024

Randomized clinical trial show that DPYD/UGT1A1 pharmacogenetic-informed therapy with fluoropyrimidines and/or irinotecan reduced the risk of toxicity by 90%

12/05/2024

A large population study reveals the contribution of chronic conditions, especially liver disease, HIV and heart conditions, on the risk of su***de in people with mental health conditions. https://buff.ly/4eXIgig Pillcheck allows whole-person therapy optimization to improve the management of depression, and reduce the risk of su***de.

This cohort study examines data for the population of Denmark across 20 years to estimate su***de risk across a range of medical conditions, gauge any dose-response–like relationship between disability burden and su***de risk, and determine any role prior mental disorder might have.

12/02/2024

La pharmacogénétique est une affaire de famille

La capacité de votre organisme à métaboliser les médicaments est régie par des variantes génétiques héritées de vos parents. Ces variantes, souvent partagées avec vos frères et sœurs, peuvent également être transmises à vos descendants. Un test pharmacogénétique permet de choisir le...

11/18/2024

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort https://buff.ly/3Zc1Y5c

11/18/2024

Ward suggested adhering to the "four pillars of frailty prevention and management," which include good nutrition with plenty of protein, exercise, optimizing medications for chronic conditions, and maintaining a strong social network. https://buff.ly/40TgJev Pillcheck enables personalized therapy management for depression, chronic pain, and blood pressure to reduce the risk of dementia.

Frailty is associated with an increased risk for dementia, new findings showed, with an acceleration of frailty observed 4-9 years prior to dementia onset.

11/17/2024

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores https://buff.ly/4fRAB5T Quite interesting analysis shoing still poor concordance of predictions, demonstrating a huge gap hindering clinical utility of PRSs.

This study aims to characterize the individual-level agreement of polygenic risk scores for coronary heart disease that perform similarly at the population level.

11/11/2024

Pharmacogenetics is a family affair. When doctors decide which medication to prescribe, they often ask about the experiences of your family members, like your parents and siblings. This is because people in the same family can share genetic traits that affect how they respond to medications. However, it’s important to remember that everyone has their own unique mix of these traits, which influences how their body processes drugs.

Your ability to metabolize drugs is determined by the genetic variants inherited from your parents, which are also likely shared with your siblings and can be passed on to your children. Pharmacogenetic testing can help guide safer and more effective medication selection for you and your family.

11/04/2024

Digital Hypertension Solutions: Medication Management Shows Superior Results https://buff.ly/4fxNfHi Pillcheck can help optimize blood pressure medications, reduce the incidence and severity of side effects, and improve treatment adherence.

PHTI reveals that digital hypertension solutions focused on medication management deliver the most significant improvements in blood pressure

11/01/2024

Excellent study: Plasma protein binding can change under pathophysiological conditions; changes in unbound drug fraction should be accounted for when using CYP probe drug plasma clearance for assessing CYP activity.

Background and objective CYP450 (CYP) phenotyping involves quantifying an individual’s plasma clearance of CYP-specific probe drugs, as a proxy for in vivo CYP enzyme activity. It is increasingly applied to study alterations in CYP enzyme activity under various (patho)physiological conditions, suc...

10/29/2024

Vitamin K2 and MK7 metabolite reduce the severity and incidence of Nocturnal Leg Cramps https://buff.ly/3Afx964 It would be interesting to know if genetic variations of CYP4AF2 that metabolizes Vitamin K have a clinical impact on the risk of leg cramps and supplement's effectiveness.

This randomized clinical trial evaluates whether vitamin K2 is better than placebo in managing nocturnal leg cramps.

10/17/2024

A Danish national study shows that long-term use of hormone-releasing IUDs increases the risk of breast cancer https://buff.ly/4hbQc1w Hormonal contraceptives also affect risk of anxiety and depression https://buff.ly/3TeizSR

This study uses data from nationwide Danish registries to assesses breast cancer risk with continuous use of levonorgestrel-releasing intrauterine systems, accounting for other hormonal exposures.