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Centre for Heart Lung Innovation

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Centre for Heart Lung Innovation

The Centre for Heart Lung Innovation is a St. Paul's Hospital and UBC Research Centre James Hogg (2013 Gairdner Wightman Award Winner) and Peter Paré.

The Centre for Heart Lung Innovation (HLI), previously known as iCAPTURE and the James Hogg Research Centre, was established as the Pulmonary Research Laboratory in 1977 by Drs. Since then it has grown dramatically in scope, size, and worldwide impact. Basic and clinician scientists work together in an exciting multidisciplinary environment to address vital issues in heart, lung, and critical care disease. Situated within Providence Health Care’s St. Paul’s Hospital, a University of British Columbia teaching hospital, the HLI is a translational research centre using our basic molecular and cellular research discoveries to develop innovative approaches to prevent and treat human disease through our complementary and connected clinical research. Our focus is on developing solutions to the biggest challenges: atherosclerosis and heart failure, emphysema and other chronic pulmonary diseases, severe infections such as COVID19 and multiple organ failure. These diseases are leading causes of morbidity, mortality and cost to society in Canada and the world. Combined, these diseases are by far the greatest killers. We seek out the underlying causes so that we can develop strategies for prevention and treatment. We link our basic discoveries to improved health care through clinical research, teaching, and by translating new knowledge into clinical practice at St. Paul’s Hospital and around the world. Since disease involves both the patient and the environment, our focus on prevention seeks to understand and prevent those patient-environment interactions that lead to disease and disability. The Centre for Heart Lung Innovation has a unique multidisciplinary milieu that takes the best attributes of a busy tertiary care hospital (St. Paul’s) and combines them with the best attributes of a leading academic institution (UBC) to generate novel insight, knowledge, and solutions. It is not uncommon within the HLI to find a mathematician, a pathologist, a surgeon, and a basic scientist, joining forces to attack otherwise intractable problems. We link basic science with clinical innovation; we link a broad knowledge of inflammation with focused investigation into heart, lung, and critical care disease; we link universities, faculties, and departments together to innovate in ways that otherwise are not possible.

11/13/2025

This Friday's Guest Speaker at the HLI is Dr. Mark Haykowsky from the University of Alberta!

10/24/2025

"HLI has taught me far more than science. It has helped foster my development as a leader, strengthened my resilience, and deepened my gratitude. It has shown me that growth does not happen in isolation, it happens in communities that believe in one another."

Dr. Gurpreet Singhera, HLI's cardiovascular biobank manager, looks back on 25 years at our centre.

🔗 Read the full story here: https://www.hli.ubc.ca/2025/10/the-journey-that-shaped-my-life/

10/21/2025

Congratulations to the HLI's Dr. Gordon Francis on receiving the Beedie Family Professorship in Cardiovascular Disease Prevention! With support from this funding, Dr. Francis will continue to advance heart health, exploring new frontiers in lipidology and cardiovascular care.

For the full story: https://helpstpauls.com/stories/2-25-million-donation-from-beedie-foundation-advances-innovative-cardiac-research-and-care/

09/19/2025

While high lipoprotein(a) (Lp(a)) levels are found in around 1.6 billion people globally, it is almost never measured. But knowing Lp(a) can be useful in informing care for patients with heart disease.

Nicol Vaizman, a MSc student at HLI, discusses a review paper from HLI showing how the landscape for Lp(a) testing is changing and why it matters.

🔗 Read the full story here: https://www.hli.ubc.ca/2025/09/time-to-test-new-hli-led-review-supports-routine-lipoproteina-testing/

08/30/2025

When Jinelle Panton got her acceptance letter to the University of British Columbia, her entire world changed. It had been a long-standing dream to obtain her PhD. But the path of pursuing tertiary education abroad would prove to be fraught with difficulties.

Read about how she persevered despite challenges, her passion for equity, diversity and inclusion, and what she learned along the way.

🔗 Read the full story here: https://www.hli.ubc.ca/2025/08/academia-who-are-you/

08/22/2025

Holding a donor lung instantly educates.

Since 1977 the James Hogg Lung Biobank (JHLB) has been collecting a growing inventory of donor lung tissue and associated clinical data.

Since Darren Sutherland is often asked, he details the journey of donor lungs and their enduring potential -- where do they come from and what happens when they arrive at the biobank.

🔗 Read the full story here: https://www.hli.ubc.ca/2025/08/legacy-of-life-the-enduring-potential-of-a-donated-lung

08/08/2025

Atherosclerosis is one of the main causes of heart disease. But experimental models of atherosclerosis don't tell the whole story.

The use of multiplex imaging could improve how we study and treat atherosclerosis.

This story, written by Eric Xiang, a PhD candidate at HLI, details how Dr. Ying Wang's lab is validating and applying this innovative technique to study atherosclerosis in human arteries.

🔗 Read the full story here: https://t.co/xPUOKCUmbJ

07/29/2025

Our 2024 Annual Report is now live! 📣

The report highlights major research breakthroughs, new community partnerships, knowledge translation, and trainee accomplishments and activities, capturing the momentum and impact of HLI’s work.

Read the report via link in bio.
Or, via this link: https://simplebooklet.com/2024-hliar

07/25/2025

"Wow… I never in my life expected that I would hold my own heart,” murmurs Asher.

His heart had once beaten inside him. Now, it’s in his hands.

𝗪𝗵𝗮𝘁 𝗵𝗮𝗽𝗽𝗲𝗻𝘀 𝘁𝗼 𝘁𝗵𝗲 𝗵𝘂𝗺𝗮𝗻 𝗵𝗲𝗮𝗿𝘁 𝗮𝗳𝘁𝗲𝗿 𝘁𝗿𝗮𝗻𝘀𝗽𝗹𝗮𝗻𝘁?

This story, written by Coco Ng, a heart biobank technician, takes you into the lab, following her day as she receives a freshly removed heart and prepares it for research.

🔗 Read the full story via link in bio.

07/18/2025

📣New project: 3D-printed heart tissue, guided by genes!

With support from Genome Canada and Genome BC, Dr. Zachary Laksman from HLI and BC-based Axolotl Biosciences () are developing a better lab model to speed up and improve drug testing for heart disease.

The project uses human genetic information (“genomics-informed”) and stem cells to create two new "bio-inks": special printing materials that produce realistic, functional heart tissue when 3D-printed in the lab.

These printed heart tissues will help researchers model disease and test new treatments more quickly, safely and accurately. Congratulations to Dr. Laksman and Axolotl Biosciences on receiving Genome Canada and Genome BC funding for this groundbreaking project!

➥Read more via link in bio.

Address

Room 166/1081 Burrard Street
Vancouver, BC
V6Z1Y6

Opening Hours

Monday	8am - 4pm
Tuesday	8am - 4pm
Wednesday	8am - 4pm
Thursday	8am - 4pm
Friday	8am - 4pm

Telephone

604-806-8346

Website

http://www.hli.ubc.ca/

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Our Story

The Centre for Heart Lung Innovation (HLI), located at St. Paul’s Hospital, Vancouver, Canada, is a University of British Columbia (UBC) research centre supported by the UBC Faculty of Medicine and Providence Health Care. Led by Director, Dr. Don Sin, and Associate Director, Dr. Jordan Guenette, investigators and trainees at the Center for Heart Lung Innovation are using the best available technology to address the most critical challenges in heart, lung, blood vessel, and critical care diseases. Our research centre houses a Cellular Imaging and Biophysics Core, a Genetically Engineered Models (GEM) facility, a Histology facility, a Molecular Phenotyping Core (including biobanking services and a NanoString nCounter system), and among the world’s largest heart and lung tissue registries. HLI is transforming patient care by pursuing important research questions, and provides a unique resource and training facility for our many partners in the academic and industrial sectors across Canada and North America.

Our vision is to be a world leader in understanding and eliminating heart, lung, blood vessels, and critical care disease.