03/27/2025
A groundbreaking study led by Dr. Jessica Eccles and published in The British Journal of Psychiatry has uncovered key brain mechanisms behind the strong connection between joint hypermobility and anxiety.
Key Findings:
- People with hypermobility show heightened activity in the amygdala (threat processing) and insular cortex (internal body signals), increasing anxiety sensitivity.
- Hypermobile individuals are 4x more likely to experience anxiety than the general population.
- Stronger brain connectivity between the amygdala and precuneus (self-awareness), possibly explaining increased anxiety levels.
This research does not suggest that EDS or HSD are "all in your head." These are real, physical conditions with complex causes. Instead, the study highlights how mental health challenges can accompany the physical symptoms, offering a more complete understanding of the brain-body connection and potential treatments for anxiety in hypermobile individuals.
Dr Eccles explained, “This research could lead to personalised treatments that help regulate brain activity and reduce anxiety symptoms for those with hypermobility.”
Hypermobility's impact on mental health is often overlooked. This study brings hope for better understanding and specialised therapies. Read the full study here: https://sussex.figshare.com/articles/journal_contribution/Neural_processes_linking_joint_hypermobility_and_anxiety_key_roles_for_the_amygdala_and_insular_cortex/28350236?file=52143758