19/07/2025
Scientists in the UK have successfully created healthy babies using a groundbreaking technique called Mitochondrial Donation Treatment (MDT)—often referred to as the "three-parent baby" method.
This technique combines the DNA of three individuals: nuclear DNA from the biological mother and father, and mitochondrial DNA from a healthy female donor.
The purpose is to prevent the transmission of mitochondrial diseases, a group of debilitating inherited disorders that can affect the heart, brain, muscles, and other organs.
As of July 2025, eight babies have been born through this method in the UK, with one additional pregnancy ongoing.
Follow-up studies and medical evaluations show that these babies are developing normally and are free of the mitochondrial diseases their biological mothers carried.
The technique works by transferring the mother’s nuclear DNA into a donor egg that has healthy mitochondria but had its own nucleus removed.
That reconstructed egg is then fertilized by the father’s s***m and implanted into the mother.
The proportion of the donor's DNA is minimal—only about 0.1%—yet it is enough to correct the mitochondrial defects.
In reported cases, levels of faulty mitochondrial DNA were either undetectable or too low to cause disease.
This medical advancement is considered a major milestone in reproductive genetics and disease prevention, although experts stress the importance of long-term monitoring to assess the health of these children as they grow.
Internationally, interest is growing, with countries like Australia preparing to launch similar trials.
However, the technique remains controversial, as it involves genetic modification and raises ethical, legal, and social concerns about gene editing, parental identity, and long-term effects.
Despite this, the scientific community views the success of these births as a hopeful step toward eradicating certain inherited diseases from future generations.