COVID Clinical

07/12/2020

As of December 1, 2020, CovidClinical.org will no longer be updated with new articles. The website will remain available as a resource for archived material. At this stage in the pandemic, the amount of novel information has slowed, and the significant breakthroughs are being reported in medical journals and often in the mainstream media, while more specialized studies are reported in their respective specialty journals. Thank you for trusting us as a source for these many months and we hope you continue to use the CovidClinical.org website to find archived information.

13/09/2020

Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children (NEJM, Original Investigation, 09/08/2020)
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2770250

Visit our complete list of weekly updates at: https://www.covidclinical.org/daily-updates

This cohort study compares the clinical features of coronavirus disease 2019 (COVID-19) with those of influenza A and B in US children.

13/09/2020

Current meta‐analysis does not support the possibility of COVID‐19 reinfections (Research Article, Journal of Medical Virology, 09/08/20)
https://doi.org/10.1002/jmv.26496

Visit our complete list of weekly updates at: https://www.covidclinical.org/daily-updates

Background COVID‐19 reinfections could be a major aggravating factor in this current pandemic, as this would further complicate potential vaccine development and help to maintain worldwide virus poc...

16/08/2020

Clinical Outcomes Associated with Methylprednisolone in Mechanically Ventilated Patients with COVID-19 (Clinical Infectious Diseases, Major Article, 08/09/2020)
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1163/5890108?searchresult=1

Visit our complete list of weekly updates at: https://www.covidclinical.org/daily-updates

AbstractBackground. The efficacy and safety of methylprednisolone in mechanically ventilated patients with acute respiratory distress syndrome due to coronavir

16/08/2020

Determinants of COVID-19 vaccine acceptance in the US (EClinicalMedicine, Article, 8/12/20)
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30239-X/fulltext

Visit our complete list of weekly updates at: https://www.covidclinical.org/daily-updates

Although our study found a 67% acceptance of a COVID-19 vaccine, there were noticeable demographic and geographical disparities in vaccine acceptance. Before a COVID-19 vaccine is introduced to the U.S., public health officials and policymakers must prioritize effective COVID-19 vaccine-acceptance m...

11/08/2020

Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea (JAMA, Original Investigation, 08/06/2020)
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2769235

Visit our complete list of updates at: https://www.covidclinical.org/daily-updates

This cohort study quantitatively describes molecular viral shedding in asymptomatic and symptomatic patients with SARS-CoV-2 infection.

11/08/2020

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 (NEJM, Article, 08/06/20)
https://www.nejm.org/doi/full/10.1056/NEJMoa2016638

Visit our complete list of updates at: https://www.covidclinical.org/daily-updates

Original Article from The New England Journal of Medicine — A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

07/08/2020

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Assessment of SARS-CoV-2 Screening Strategies to Permit the Safe Reopening of College Campuses in the United States (JAMA, Original Investigation, 07/31/2020)
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2768923

This analytic modeling study defines the screening performance standards for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests that would permit the safe return of students to US residential college campuses for the fall 2020 semester.

01/08/2020

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Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US (JAMA, Original Investigation, 7/29/20)
https://jamanetwork.com/journals/jama/fullarticle/2769034

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This population epidemiology study estimates associations of school closures in the US and the timing of those closures in March 2020 with change in daily coronavirus disease 2019 (COVID-19) incidence and mortality through the first week of May, accounting for other contemporaneous public health...

28/07/2020

https://jamanetwork.com/channels/health-forum/fullarticle/2768376

Masking or face covering amid the global coronavirus disease 2019 (COVID-19) pandemic has emerged as a highly polarizing practice, with surprising partisan divisions. While masking remains contentious, there is bipartisan agreement among policy makers that medical exemptions for masking are...

28/07/2020

07/28/20

"This is the first time an experimental COVID-19 vaccine tested in nonhuman primates has been shown to produce such rapid viral control in the upper airway.."

https://www.nih.gov/news-events/news-releases/experimental-covid-19-vaccine-protects-upper-lower-airways-nonhuman-primates

NIH-led study of mRNA vaccine supports advance to Phase 3 human trials.

28/07/2020

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Characteristics and roles of SARS‐CoV‐2 specific antibodies in patients with different severities of COVID‐19 (Clinical and Experimental Immunology, Article, 07/24/20)
https://onlinelibrary.wiley.com/doi/10.1111/cei.13500

Background The diagnosis of COVID‐19 relies mainly on viral nucleic acid detection, but false negatives can lead to missed diagnosis and misdiagnosis. SARS‐CoV‐2‐specific antibody detection is conve...

20/07/2020

"... household transmission of SARS-CoV-2 was high if the index patient was 10–19 years of age."

"... highest COVID-19 rate (18.6% [95% CI 14.0%–24.0%]) for household contacts of school-aged children and the lowest (5.3% [95% CI 1.3%–13.7%]) for household contacts of children 0–9 years in the middle of school closure."

https://wwwnc.cdc.gov/eid/article/26/10/20-1315_article

We analyzed reports for 59,073 contacts of 5,706 coronavirus disease (COVID-19) index patients reported in South Korea during January 20–March 27, 202...

20/07/2020

Promising Oxford Vaccine (07/20/20)

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext

ChAdOx1 nCoV-19 showed an acceptable safety profile, and homologous boosting increased antibody responses. These results, together with the induction of both humoral and cellular immune responses, support large-scale evaluation of this candidate vaccine in an ongoing phase 3 programme.

19/07/2020

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Impact of delays on effectiveness of contact tracing strategies for COVID-19: a modeling study (Lancet Public Health, Article, 07/16/2020)
https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(20)30157-2/fulltext

Kidney allograft recipients, immunosuppression, and coronavirus disease-2019: a report of consecutive cases from a New York City transplant center (Nephrology Dialysis Transplantation, Article, 07/17/20)
https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfaa154/5873247?searchresult=1

In our model, minimising testing delay had the largest impact on reducing onward transmissions. Optimising testing and tracing coverage and minimising tracing delays, for instance with app-based technology, further enhanced contact tracing effectiveness, with the potential to prevent up to 80% of al...

16/07/2020

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SARS-CoV-2 Antibody Responses Do Not Predict COVID-19 Disease Severity (American Journal of Clinical Pathology, Article, 07/15/20)
https://academic.oup.com/ajcp/article/doi/10.1093/ajcp/aqaa123/5871644?searchresult=1

AbstractObjectives. Initial reports indicate adequate performance of some serology-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assays. H

16/07/2020

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An mRNA Vaccine against SARS-CoV-2 — Preliminary Report (NEJM, Original Article, 07/14/2020
https://www.nejm.org/doi/full/10.1056/NEJMoa2022483?query=featured_coronavirus

Original Article from The New England Journal of Medicine — An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

14/07/2020

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Clinical Characteristics of Pregnant Women with CoronavirusDisease 2019 in Wuhan, China (Open Forum Infectious Diseases, Manuscript, 07/11/20)
https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofaa294/5870370?searchresult=1

AbstractBackground. Coronavirus disease 2019 (COVID-19) has become a pandemic. Despite of the growing number of patients with COVID-19 infection, data on the c