24/09/2023
Congratulations to Duygu Yazici, one of our postdocs, for her insightful presentations at the EAACI Summer Symposium on Epithelial Cell Biology at Imperial College, London.
Disrupted epithelial permeability as a predictor of severe COVID-19 development
An impaired epithelial barrier integrity in the gastrointestinal tract is important in the pathogenesis of many inflammatory diseases. Accordingly, the authors assessed the potential of biomarkers of epithelial barrier dysfunction as predictive of severe COVID-19. The results demonstrate that biomarkers of intact or defective epithelial barriers are associated with disease severity and can provide early information on the prediction at the time of hospital admission.
Yazici, D., Cagan, E., Tan, G., Li, M., Do, E., Kucukkase, O. C., Simsek, A., Kizmaz, M. A., Bozkurt, T., Aydin, T., Heider, A., RĂĽckert, B., BrĂĽggen, M. C., Dhir, R., O'Mahony, L., Akdis, M., Nadeau, K. C., Budak, F., Akdis, C. A., & Ogulur, I. (2023). Disrupted epithelial permeability as a predictor of severe COVID-19 development. Allergy, 10.1111/all.15800. Advanced publication. https://doi.org/10.1111/all.15800
Epithelitis: barrier disruption and activation of pro-inflammatory pathways in gut epithelial cells by food emulsifiers.
Food emulsifiers are frequently used as food additives, primarily in processed foods, serving as stabilisers for emulsions. The regulations governing their usage in food are primarily based on animal studies, with a limited assessment of their molecular toxicity such as their impact on epithelial cell physiology and tissue inflammation. In this context, researchers elucidated the effects of food emulsifiers on the gut epithelial barrier using a gut-on-a-chip system, employing transcriptomics and proteomics.
European Academy of Allergy and Clinical Immunology – EAACI
