11/01/2026
đ Avoid FOOD ADDITIVES! Eat real, whole foods!
In the NutriNet-Santé cohort, several preservative additives (nitrites, phosphates, sorbates, propionates, ascorbates, and related compounds) were associated with increased type 2 diabetes incidence, even after statistical adjustment for ultra-processed food intake.
The growing body of mechanistic data suggests that these additives can impair insulin signaling, promote oxidative stress, alter gut microbiota, and interfere with mitochondrial metabolism â all plausible causal routes.
Although residual confounding cannot be excluded, the consistency between epidemiologic and mechanistic evidence challenges the notion that UPF-associated metabolic harm is purely nutritional. Instead, chronic additive exposure itself may be a metabolic stressor.
These findings support precautionary policies favoring additive reduction and greater transparency in food labeling.
https://www.nature.com/articles/s41467-025-67360-w