TacMed Dept - Suisse

04/08/2025

31/05/2025

TacMed Dept HQ - Belgium

In an emergency trauma training course 28 pigs, all with shock indexes over 1.0, received various doses and routes of TXA administration.

30 mg / kg IM (equivalent to 2 grams in an adult male) achieved equal serum concentrations to 15 mg / kg IV (1 gram for an adult male), initially and maintained it longer IM than IV.

This is further proof of concept for potential IM administration of TXA. However, current formulations would require 20 ml of this does IM which is four times more than typical recommended for IM administration.

Since the most robust survival benefit data is from CRASH-2 using only IV TXA, extrapolating serum concentrations of IM administered TXA as providing the same improved mortality is purely theoretical. Additionally, with a more prolonged serum concertation will there be more adverse events like seizures and venous thrombosis.

Finally, current TCCC guidelines call for 2 grams IV / IO slow push, also a dosing change from CRASH-2.

Co-TCCC decided in 2025 that there still wasn’t enough evidence to support IM TXA, but the literature is growing.

Lynghaug T, Bakke HK, Fuskevåg OM, Nielsen EW, Dietrichs ES. HOW SHOULD TRANEXAMIC ACID BE ADMINISTERED IN HEMORRHAGIC SHOCK? CONTINUOUS SERUM CONCENTRATION MEASUREMENTS IN A SWINE MODEL. Shock. 2023 Nov 1;60(5):707-712. doi: 10.1097/SHK.0000000000002222. Epub 2023 Sep 2. PMID: 37695638; PMCID: PMC10662641.

05/01/2024

https://youtu.be/fZXk8_WHCbw?si=KBzcij1lfWS_E16a

Immersion vous emmène au cœur des opérations de cette unité d’élite. Nous les avons suivis durant plusieurs semaines. Vous ne verrez jamais leur visage car c...

09/04/2023

Toute l’équipe de TacMed Dept - Suisse vous souhaite de joyeuses fêtes de Pâques

24/12/2022

Le Team TacMed Swiss vous souhaite de merveilleuses et incroyables fêtes de fin d’année à vous et vos proches et surtout Stay Safe

28/04/2022