Nicollier-Schlegel SARL

Nicollier-Schlegel SARL History of the company and of Advanced ECG:

Nicollier-Schlegel SARL is a family company formed in Switzerland in 2013 by Todd Schlegel, MD.

We're the home of Advanced ECG (A-ECG), a new software technology originally developed at NASA that remotely applies pattern recognition and "big data" to help clinicians more accurately yet inexpensively detect heart diseases on their patients' ECGs. We are the home of Advanced ECG, also known as "A-ECG". After finishing medical training at the Mayo Clinic in 1992, Dr. Schlegel joined NASA's John

son Space Center in Houston, Texas. During much of his subsequent 20+ year career at NASA as a physician-scientist, and since leaving his full-time position with NASA in 2013, Dr. Schlegel has been continuously integrating and developing different types of advanced ECG software technologies designed to better detect and prevent cardiovascular problems in astronauts. During this time Dr. Schlegel has also published dozens of peer-reviewed papers on advanced ECG ("A-ECG") in the scientific and medical literature and produced several ECG-related patents for NASA. In 2013, increasingly realizing that the latest generation of software he'd been integrating from collaborators around the world would especially benefit those larger numbers of patients, clinicians and researchers who did not have direct access to NASA, Dr. Schlegel early-retired from his scientific and clinical positions at NASA and co-founded, in conjunction with his wife Maya, a US-trained attorney, a new company focused on further developing A-ECG. This new company, Nicollier-Schlegel SARL, was founded in Switzerland at the same time as the founders' move, with their two young sons, to Switzerland from Houston. Since then, any researcher, clinician or other professional who digitally collects or stores conventional 12-lead ECG data files has been able to seamlessly access the latest generation of integrated A-ECG technologies and receive A-ECG Reports for their patients or test subjects through our company. Scientific details on A-ECG can be found in other sections of this page, especially within the links to related publications and patents. Dr. Schlegel is a recipient of multiple awards, including a Presidential Early Career Award from the White House Office of Science and Technology Policy (Clinton White House), several NASA patents for both ECG-related software and hardware, several honors for student mentoring awarded both by NASA and by independent student organizations, and a NASA technology achievement medal. He also currently maintains an academic affiliation with the Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Below is a series of seven, brief informational videos on clinical A-ECG that were recorded several years ago, but that ...
19/11/2024

Below is a series of seven, brief informational videos on clinical A-ECG that were recorded several years ago, but that are still useful for A-ECG teaching purposes. Video 1 just shows what a “normal, healthy heart” looks like by A-ECG, to provide that necessary background.

The next five videos thereafter then show both the conventional 12-lead and A-ECG results for patients with different heart pathologies, specifically for patients with coronary artery disease (video 2), non-ischemic cardiomyopathy (video 3), left ventricular hypertrophy (video 4), genetic hypertrophic cardiomyopathy (video 5) and genetic long QT syndrome (video 6), respectively.

Some of the cases with disease were specifically chosen because they illustrate how conventional 12-lead ECG is often “falsely normal”, or only non-specifically abnormal, in the context of major underlying heart disease, whereas at the same time, A-ECG is readily able to identify as well as specifically characterize the given disease. The seventh and final video “pulls everything together”, both statistically and through our standard clinical A-ECG display, showing where each patient’s result ends up on that display.

Video 1: A-ECG results in a healthy patient:
https://www.youtube.com/watch?v=kHdQAG-Mqak

Video 2: A-ECG results in a patient with single-vessel coronary artery disease (see Video 7 for her final diagnostic characterization): https://www.youtube.com/watch?v=A9qbiHy15CU

Video 3: A-ECG results in a patient with non-ischemic cardiomyopathy (NICM) and low cardiac ejection fraction (see Video 7 for his final diagnostic characterization): https://www.youtube.com/watch?v=3ROsbYD0xbA

Video 4: A-ECG in a patient with left ventricular hypertrophy (due to aortic stenosis, see Video 7 for his final diagnostic characterization, noting that his data come from a standard 10-sec ECG, not from a higher fidelity, ~5-min ECG): https://www.youtube.com/watch?v=E4e9wYdrXrk

Video 5: A-ECG in a patient with genetic hypertrophic cardiomyopathy (see Video 7 for his final diagnostic characterization, noting that his data come from a standard 10-sec ECG, not from a higher fidelity ~5-min ECG): https://www.youtube.com/watch?v=e9ZGopaz_g8

Video 6: A-ECG in a patient with genetic ion channelopathy (long QT syndrome; see Video 7 for his final diagnostic characterization, noting that his data come from a standard 10-sec ECG, not from a higher fidelity ~5-min ECG): https://www.youtube.com/watch?v=ge-LzFp7rcs

Video 7: The specific “disease calls” for each of the above patients by A-ECG, after appropriate statistical analyses, and as shown on the final diagnostic display: https://www.youtube.com/watch?v=j37h1NxMbpE

made with ezvid, free download at http://ezvid.com

Our latest peer-reviewed publication, dated 09 October 2024. This one describes one of our newer advanced ECG methods th...
13/11/2024

Our latest peer-reviewed publication, dated 09 October 2024. This one describes one of our newer advanced ECG methods that also allows us to "Heart Age Score" the conventional 12-lead ECGs of patients who are in atrial fibrillation or who otherwise lack definable P waves. While this is actually something we've been doing now clinically for some time, it's great to have both the methods and the related rich results (i.e., the clinical utility of this newer score for predicting cardiovascular events) described in such exquisite detail so that others can make use of them. Congratulations especially to Dr. Zaidon Al-Falahi, from the University of Sydney in Australia, for his outstanding first-author work on this publication.

https://academic.oup.com/ehjdh/advance-article/doi/10.1093/ehjdh/ztae075/7816279?login=false

Our latest peer-reviewed publication (April 2024). This one is especially focused on the use of advanced ECG (A-ECG) to ...
17/05/2024

Our latest peer-reviewed publication (April 2024). This one is especially focused on the use of advanced ECG (A-ECG) to more accurately identify apical hypertrophic cardiomyopathy via standard 12-lead ECG than has been previously accomplished. The more general, overall diagnostic performance of A-ECG for distinguishing, via standard 12-lead ECG, multiple types of heart diseases from one another and from health, especially via A-ECG-related linear discriminant analysis (LDA) as clinically practiced today, is also discussed within this publication, specifically within its Tables 4 and 5 and Figure 2 and related text. Congratulations to Dr. Rebecca Hughes, from University College London, for her outstanding first-author work on this publication.

AbstractAims. Typical electrocardiogram (ECG) features of apical hypertrophic cardiomyopathy (ApHCM) include tall R waves and deep or giant T-wave inversio

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Advanced ECG: History

Nicollier-Schlegel SARL is a family company formed in Switzerland in 2013 by Todd Schlegel, MD. We are the home of Advanced ECG, also known as "A-ECG".

After finishing medical training at the Mayo Clinic in 1992, Dr. Schlegel joined NASA's Johnson Space Center in Houston, Texas. During much of his subsequent 20+ year career at NASA as a physician-scientist, and since leaving his full-time position with NASA in 2013, Dr. Schlegel has been continuously integrating and developing different types of advanced ECG software technologies designed to better detect and prevent cardiovascular problems in astronauts. During this time Dr. Schlegel has also published dozens of peer-reviewed papers on advanced ECG ("A-ECG") in the scientific and medical literature and produced several ECG-related patents for NASA.

In 2013, increasingly realizing that the latest generation of software he'd been integrating from collaborators around the world would especially benefit those larger numbers of patients, clinicians and researchers who did not have direct access to NASA, Dr. Schlegel early-retired from his scientific and clinical positions at NASA and co-founded, in conjunction with his wife Maya, a US-trained attorney, a new company focused on further developing A-ECG. This new company, Nicollier-Schlegel SARL, was founded in Switzerland at the same time as the founders' move, with their two young sons, to Switzerland from Houston. Since then, any researcher, clinician or other professional who digitally collects or stores conventional 12-lead ECG data files has been able to seamlessly access the latest generation of integrated A-ECG technologies and receive A-ECG Reports for their patients or test subjects through our company.

Scientific details on A-ECG can be found in other sections of this page, especially within the links to related publications and patents.