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International Journal of Particle Therapy

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International Journal of Particle Therapy

The International Journal of Particle Therapy (IJPT) is the official open access journal of the Particle Therapy Cooperative Group (PTCOG).

21/11/2025

Rates of local regional recurrence and secondary metachronous thoracic tumors remain high for patients with inoperable early and locally advanced non-small cell lung cancer treated with prior radiation.

These clinical situations pose therapeutic challenges due to the potential added toxicity of reirradiation.

During Lung Cancer Awareness Month, we are pleased to present a study demonstrating the feasibility and efficacy of a hypofractionated course of proton reirradiation for recurrent thoracic tumors - in press with IJPT now: https://www.sciencedirect.com/science/article/pii/S2331518025004780

14/11/2025

Developing consensus guidelines and integrating advanced relative biological effectiveness (RBE) and LET-based models into treatment planning could improve precision and safety of proton therapy.

Read the results of an important survey of 29 U.S. proton therapy centers assessing awareness and management of RBE variability in clinical practice: https://www.sciencedirect.com/science/article/pii/S2331518025004779

12/11/2025

Our first AI in Particle Therapy Special Issue article is available!

Radiotherapy can lead to radiation-induced optic neuropathy, with vision loss and visual field deficits related to damage to the optic pathways: Accurately quantifying visual field deficits and establishing their spatial relationship with anatomical structures and radiation dose distribution remains a significant challenge.

Learn how researchers from Université de Caen- Normandie; Centre François Baclesse; and Hôpital de La Croix-Rousse, Hospices Civils de Lyon applied a novel artificial intelligence approach in oncology to identify patterns of visual field loss and model their spatial evolution over time after pencil beam scanning proton therapy: https://www.sciencedirect.com/special-issue/10J8TL0GQ4D

27/10/2025

Kidney cancer represents 4% of all new cancer cases in the United States and there has been a consistent increase in its incidence over recent decades, largely attributed to more frequent use of routine imaging studies for unrelated medical reasons.

Read a study in press now with IJPT that suggests proton-based SBRT improved target coverage while reducing the dose to OARs in primary renal cell carcinoma patients: https://www.sciencedirect.com/science/article/pii/S2331518025004755

06/10/2025

The modern proton therapy center is a complex environment – numerous factors influence patient treatment time – and with 29 new centers opened last 5 years, the National Association of Proton Therapy reports that the number of patients treated with protons has nearly tripled since 2012.

There is a pressing need for data from modern proton therapy centers to inform operational planning for new facilities and provide benchmarks for existing ones: Read important treatment time insights from the Baptist Health Miami Cancer Institute’s Real Time Location Service (RTLS) system, in press with IJPT now - https://www.sciencedirect.com/science/article/pii/S2331518025004731

03/10/2025

Most automatic error detection studies in radiation therapy focus on photon therapy, with limited attention to proton therapy. Read a UF Health Proton Therapy study that developed and validated an automated framework for initial proton therapy plan review, enhancing error detection capabilities and workflow efficiency in pencil beam scanning (PBS) treatments - learn more: https://www.sciencedirect.com/science/article/pii/S233151802500472X

25/09/2025

In press now: Excessive quality assurance computed tomography scans can increase patient burden, resource use, and healthcare costs - read a Johns Hopkins University School of Medicine study that evaluates the impact of standardized minimum QACT frequencies across treatment sites. https://www.sciencedirect.com/science/article/pii/S2331518025004706

16/09/2025

In press now: Read a collaborative Juntendo University- Harvard Medical School study that suggests both X-rays and protons may cause radiation-induced bystander responses in osteoblasts and osteoclasts, irrespective of cell combination, dose, or radiation type: https://www.sciencedirect.com/science/article/pii/S2331518025004664

08/09/2025

Volume 17 is online now! Read articles related to IMPT Versus IMRT for breast cancer, protons or photons in pituitary neuroendocrine tumors, NTCP-based prediction of lung sparing with IMPT, and more: https://www.sciencedirect.com/journal/international-journal-of-particle-therapy/vol/17/suppl/C

14/08/2025

Clear cell adenocarcinoma of the uterine cervix is a rare and aggressive subtype of cervical cancer, typically resistant to conventional radiotherapy and lacking dedicated treatment guidelines. Read a case report in press now with IJPT that suggests a carbon ion radiotherapy boost is feasible, safe, and achieves long-term local control: https://www.sciencedirect.com/science/article/pii/S2331518025004639

28/07/2025

Understanding how cells respond to - and repair - DNA damage is crucial for optimizing radiotherapy. Review a new study that evaluates how loss of different DNA DSB repair genes impacts radiosensitivity, in press now with IJPT: https://www.sciencedirect.com/science/article/pii/S2331518025004615

17/07/2025

Registration is now open for the -NA 11th Annual Meeting in Shreveport November 7-9, 2025. Take advantage of Early Bird Rates until August 20th! Learn more: https://www.ptcog-na.org/ptcog-na-11th-annual-meeting/registration

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Welcome to the only journal specializing in particle therapy.

We are the official journal of the Particle Therapy Cooperative Group, providing a preferred venue for disseminating the most up-to-date information on the clinical, physical, and biological research in proton, light-ion, and heavy charged-particle therapy. Since 2014, we are the only journal that specializes in particle therapy, a unique subject of growing interest to health researchers as the number of particle facilities increases internationally.