Laboratorio de Función y Reactividad Vascular - LFRV

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Laboratorio de Función y Reactividad Vascular - LFRV

Our aim is studying the Cardiovascular adaptations to perinatal hypoxia and oxidative stress (systemic, cellular and molecular mechanisms).

Vascular adaptations to perinatal hypoxia and oxidative stress. Our Laboratory (Laboratory of Vascular Function and Reactivity) is interested in the effects of acute and chronic hypoxia and oxidative stress during gestation. Specifically, we are focused in the cardiovascular effects on the fetus, neonate and adult (immediate, short and long-lasting effects) and the determinant adaptive mechanisms. Our ongoing experimental models study pathologies associated with cardiac and vascular dysfunctions such as neonatal pulmonary hypertension, adult systemic hypertension and pre-eclampsia. In addition, we are assessing potential therapeutic interventions with antioxidants, vasodilators and anti-remodeling agents to treat vascular dysfunction. Our research involves an integrative approach with systemic (in vivo), isolated organs-tissues (ex vivo), and cellular and molecular (in vitro) methodologies.

19/06/2025

Well done Esteban et al....bravo!!!

Gestational chronic hypoxia impacts prenatal development, leading to fetal growth restriction (FGR), defined as the fetus’s failure to reach its genetic growth potential. Postnatal hypoxia in the cerebral tissue can induce a redox imbalance and mitochondrial dysfunction, consequently increasing ne...

19/06/2025

Another traslational paper, great collaboration with INT hospital!

Pulmonary arterial hypertension (PAH) Group 1 from the World Health Organization (WHO) is a rare, severe chronic, and progressive condition. Patients with PAH have increased oxidative stress (OS) and...

02/12/2024

Felicitaciones al Lab, en particular a Adolfo Paz por un nuevo aporte al conocimiento de la programación fetal!!

01/12/2024

Gran participación del Lab con 5 pósters en las VI jornadas de investigación del HCUCH-ICBM. Felicitaciones a Pedro Herrera que obtuvo el premio al mejor poster ICBM!

06/09/2024

Great to catch-up with colleagues at the feps2024 in the amazing Granada! Amanda Sferruzzi-Perri arribas zaugg Paula Marin

16/03/2024

Patrocinio al concurso FONDECYT postdoctoral 2024 (ANID Chile) a investigadores con interés en descifrar los mecanismos involucrados en la programación cardiovascular y envejecimiento inducidos por hipoxia crónica durante la gestación. Gran oportunidad de aprender e implementar una aproximación integrativa (in vivo, ex vivo, in vitro, in silico) en una grato y desafiante ambiente científico. Interesad@s contactarme eaherrera@uchile.cl.

Sponsorship for FONDECYT 2024 postdoctoral grants (ANID Chile) for researchers interested in deciphering the mechanisms involved in cardiovascular programming and aging induced by chronic hypoxia during pregnancy. Great opportunity to learn and implement an integrative approach (in vivo, ex vivo, in vitro, in silico) in a pleasant and challenging scientific environment. If you are interested, contact me eaherrera@uchile.cl.

01/03/2024

The SRI acknowledges that we are meeting in the unceded traditional homelands of the Musqueam, Squamish, and Tsleil-Waututh Nations.

23/12/2023

Felicitaciones al Dr Emilio Herrera, Director del LFRV por su elección como nuevo Director del ICBM! Es un gran reconocimiento a su liderazgo y compromiso institucional! Buena suerte en este nuevo desafío.

28/07/2023

www.valdivia2023.com
We have open a late abstract call until August 11th. Please visit the meeting website for more info! You cannot miss this great meeting!

Valdivia2023

21/06/2023

https://www.nature.com/nature-index/annual-tables/2023/institution/academic/all/regions-South%20America

The Nature Index tracks the affiliations of high-quality scientific articles. Updated monthly, the Nature Index presents research outputs by institution and country. Use the Nature Index to interrogate publication patterns and to benchmark research performance.

21/06/2023

https://uchile.cl/noticias/206394/ranking-nature-2023-u-de-chile-es-la-mejor-del-pais😊

Nuestro país ha consolidado su posición como referente de investigación en Latinoamérica en el Ranking Nature Index, clasificación que evalúa la producción científica de

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http://www.lab-vascular.com/

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