30/09/2021
AKUAMMA SEEDS
The main alkaloids making the plant highly potent and effective include;
- Akuammidine- this is the seeds’ main alkaloid and works by influencing opioid binding sites. The alkaloid provides analgesic qualities to help in eradicating pain as well as serving as a muscle relaxant.
Akuammine- this alkaloid has a higher affinity for mu-opioid binding sites, unlike the
- Akuammidine. It helps with providing analgesic effects, however, may cause an inhibitory impact on the peristaltic movement of the intestines if used in higher doses.
Akuammicine- this alkaloid, on the other hand, has a higher affinity for kappa-opioid binding sites.
- Pseudo-Akuammigine- this alkaloid provides both anti-inflammatory and analgesic effects. Depending on the dosage, the alkaloid excites, modulates the skeletal muscle contraction, smooth muscle contraction, central nervous system, and respiration.
- Akuammigine- this one has only shown to have an anti-adrenergic effect on blood vessels as well as the heart.
Pericine- this one has been indicated to bind to mu-opioid receptors, however, may cause convulsions resulting in involuntary contraction of muscles.