Chinese Medical Journal

Chinese Medical Journal As the official journal of Chinese Medical Association, CMJ is an international peer-reviewed genera

A study published in the Chinese Medical Journal reveals that pituitary neuroendocrine tumors have distinct immune cell ...
06/03/2026

A study published in the Chinese Medical Journal reveals that pituitary neuroendocrine tumors have distinct immune cell patterns.

The PIT1 lineage is enriched with CD4+ regulatory T (Treg) and T follicular helper (Tfh) cells and collagen-producing fibroblasts. Researchers also found a key immunosuppressive interaction between Treg cells and macrophages through CTLA4–CD86 signaling.

Read more: https://journals.lww.com/cmj/fulltext/9900/single_cell_transcriptomics_reveals_the_landscape.1901.aspx

Pancreatic cancer is aggressive and acquired resistance to gemcitabine-based chemotherapy worsens the prognosis. A Chine...
06/03/2026

Pancreatic cancer is aggressive and acquired resistance to gemcitabine-based chemotherapy worsens the prognosis.

A Chinese Medical Journal study shows that enrichment of PRRX2+ epithelial cells (EC) and SPP1+ tumor-associated macrophages (TAM) induced drug resistance. Using single-cell and bulk RNA sequencing of tumors, the study reports that this PRRX2+EC and SPP1+TAM communication led to extracellular matrix remodeling, cancer cell transition into mesenchymal state and promoted migration, ultimately driving drug resistance.

This new understanding of the cellular mechanisms driving therapy resistance will help in identifying new targets for pancreatic cancer therapeutics.

Read more: https://journals.lww.com/cmj/fulltext/9900/single_cell_and_spatial_transcriptomics_reveal_the.1886.aspx

The role of induction of anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (TKIs) in advanced non-small cell l...
05/03/2026

The role of induction of anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (TKIs) in advanced non-small cell lung cancer (NSCLC) harboring ALK-fusion is not well-documented. A recently published research article in the Chinese Medical Journal has demonstrated the short-term and long-term efficacy of ALK-targeted induction therapy in stage III lung cancer. Aceltinib-induction therapy showed a superior pathological response and improved survival rates compared to crizotinib-induction.

Read more: https://journals.lww.com/cmj/fulltext/9900/induction_alectinib_or_crizotinib_for_stage_iii.1769.aspx

A major challenge in the treatment of atopic dermatitis (AD) is determining the severity and deciding the time course fo...
04/03/2026

A major challenge in the treatment of atopic dermatitis (AD) is determining the severity and deciding the time course for initiation of systemic therapy.

A new study published in the Chinese Medical Journal introduces a simplified AD assessment scale and consensus-based treatment criteria, aiming to improve clinical efficiency, standardize decision-making, and improve patient outcomes in real-world settings.

Read more: https://journals.lww.com/cmj/fulltext/9900/developing_a_simplified_assessment_scale_of.1874.aspx

Psoriasis is a systemic disease that affects a patient’s quality of life. In a study published in the Chinese Medical Jo...
03/03/2026

Psoriasis is a systemic disease that affects a patient’s quality of life. In a study published in the Chinese Medical Journal, researchers analyzed the dermatology life quality index (DLQI) score in over 8,800 patients and identified key demographic and clinical factors that impact the quality of life in individuals with psoriasis, such as disease severity, work status, and lesion location.

Read more: https://journals.lww.com/cmj/fulltext/9900/factors_influencing_quality_of_life_in_patients.1876.aspx

Sepsis is associated with organ dysfunction and mortality, and early diagnosis for timely treatment requires effective b...
02/03/2026

Sepsis is associated with organ dysfunction and mortality, and early diagnosis for timely treatment requires effective biomarkers.

A recent study in the Chinese Medical Journal has identified a novel prognostic biomarker, the PC-esterase domain containing 1B (PCED1B) protein, that has strong causal association with 28-day mortality in patients with sepsis.

The study revealed that naive CD4+ T cells from patients with sepsis had elevated expression of PCED1B. Further, PCED1B+ CD4+ T cells may modulate immune responses and metabolism during sepsis through their interactions with dendritic cells and B cells, presenting PCED1B as a promising therapeutic target in sepsis management.

Read more: https://journals.lww.com/cmj/fulltext/9900/protective_role_of_pced1b_expressing_naive_cd4__t.1898.aspx

Mother-to-child transmission of chronic hepatitis B (CHB) infection has serious consequences and leads to liver cirrhosi...
27/02/2026

Mother-to-child transmission of chronic hepatitis B (CHB) infection has serious consequences and leads to liver cirrhosis and hepatocellular carcinoma in adulthood.

A new real-world study published in the Chinese Medical Journal reports that timely intervention with antiviral treatment using lamivudine monotherapy and add-on interferon-α therapy, in infants under the age of 1 year, can achieve functional cure.

Read more: https://journals.lww.com/cmj/fulltext/9900/high_rate_of_functional_cure_in_infants_with.1892.aspx

A recent review in the Chinese Medical Journal examines the complex role played by the autophagy-associated transmembran...
26/02/2026

A recent review in the Chinese Medical Journal examines the complex role played by the autophagy-associated transmembrane protein etoposide-induced 2.4 (EI24) in tumorigenesis, emphasizing its clinical significance in diagnostics and prognosis.

The review integrates mechanistic understanding of the multifaceted roles of EI24 with therapeutic innovation by providing details of emerging therapies targeting EI24 in diverse cancers.

Find out more at: https://journals.lww.com/cmj/fulltext/9900/biological_significance,_molecular_mechanisms_and.1889.aspx

The Chinese Medical Journal recently published the analysis of data from the ChinaHEART project evaluating the impact of...
25/02/2026

The Chinese Medical Journal recently published the analysis of data from the ChinaHEART project evaluating the impact of cardiovascular–kidney–metabolic (CKM) syndrome on mortality. The study reports that advanced stages of CKM correlated with increased risk of mortality from cardiovascular diseases.

The key finding is that stratifying patients with CKM according to the presence and severity of CKD and metabolic risk factors improves the accuracy of evaluating the mortality risk, highlighting that maintaining renal function can considerably reduce the risk of mortality.

Read more: https://journals.lww.com/cmj/fulltext/9900/association_of_cardiovascular_kidney_metabolic.1891.aspx

Breast cancer (BC) is the most common malignancy among women. A new Chinese Medical Journal study analyzed the global BC...
24/02/2026

Breast cancer (BC) is the most common malignancy among women. A new Chinese Medical Journal study analyzed the global BC incidence and mortality in 2022, and projected the future trend expected in 2050. The key finding is that countries with a high human development index have a higher incidence of BC and associated mortality in women over 50 years of age, presenting a serious healthcare challenge.

The study points to the importance of better prevention, early detection, and improved therapeutics to alleviate its global burden.

Read the full study at: https://journals.lww.com/cmj/fulltext/9900/global_burden_and_trends_of_breast_cancer_.1894.aspx

The poor therapeutic efficiency of current treatment strategies against gliomas or malignant brain tumors have fueled th...
22/02/2026

The poor therapeutic efficiency of current treatment strategies against gliomas or malignant brain tumors have fueled the search for newer targets.

A recent article published in the Chinese Medical Journal reveals a key role for choline kinase α (CHKA) in glioma cell proliferation, migration, and invasion through its ability to upregulate the epidermal growth factor receptor (EGFR).

The findings point to CHKA as a potential target for glioma treatment.

Read more: https://journals.lww.com/cmj/fulltext/9900/choline_kinase___interacts_with_epidermal_growth.1896.aspx

Clonal hematopoiesis of indeterminate potential (CHIP) is increasingly gaining evidence as a marker of aging and disease...
22/02/2026

Clonal hematopoiesis of indeterminate potential (CHIP) is increasingly gaining evidence as a marker of aging and disease risk.
In an article published in Chinese Medical Journal, researchers reveal that CHIP is associated with increased risk of multiple systemic diseases and cause-specific mortality, highlighting its potential role as a broad risk factor for human health.

Read more: https://journals.lww.com/cmj/fulltext/9900/clonal_hematopoiesis_is_associated_with_future.1880.aspx

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