14/10/2024
October 13, 2024 is the 11th World Thrombosis Day, aimed at raising public awareness of thrombotic diseases and further reducing the occurrence and harm of venous thrombosis through education and awareness raising.
The formation of blood coagulation is usually related to the following factors:
1. Vascular injury: Vascular injury is an important cause of thrombosis, such as surgery, trauma, burns, etc. These factors can damage endothelial cells, causing platelets and fibrin to aggregate at the damaged site and form blood clots. 2. Increased blood coagulation: Increased blood coagulation means that blood is prone to forming blood clots. For example, factors such as an increase in platelet count and fibrinogen content in the blood can lead to an increase in blood clotting. 3. Slow blood flow: Long term sitting, bed rest, and other unhealthy habits may lead to slow blood flow, providing conditions for thrombus formation. For example, patients who travel by plane, car, or bed for a long time are prone to developing deep vein thrombosis in the lower limbs.
2. Pay attention to the risk of thrombosis. After any part of the body's blood vessels become blocked, it can cause organ damage, resulting in insufficient blood supply to related organs, leading to serious consequences and even sudden death. Thrombosis can form in the blood vessels of the brain, leading to cerebral infarction (stroke); If it occurs in the coronary artery, it may lead to myocardial infarction (MI); Once the pulmonary blood vessels are blocked, it may lead to fatal pulmonary embolism... These diseases closely related to blood clots, such as myocardial infarction, cerebral infarction, lower limb vascular disease, etc., are all serious threats posed by blood clots to the human body. Venous thromboembolism (VTE): VTE includes pulmonary embolism (PE) and deep vein thrombosis (DVT), which mainly occur due to factors such as slow venous blood flow, venous vessel damage, and increased blood coagulation, leading to abnormal coagulation of blood in the veins and the formation of thrombi. Venous vessels are completely or partially blocked, affecting normal blood circulation. VTE is also the world's third largest cardiovascular disease after ischemic heart disease and stroke. Because of its high incidence rate, hidden symptoms and high mortality, it is known as the "silent killer". Therefore, it is particularly important to prevent thrombosis, detect thrombosis in a timely manner, and take measures to treat thrombosis.
The important role of D-Dimer&FDP combined application in preventing VTE
1. Thrombosis exclusion/diagnosis and dynamic monitoring: ① Deep vein thrombosis and pulmonary embolism (early exclusion diagnosis, low to moderate clinical likelihood population), when D-dimer&FDP negative, the risk of thrombosis can be temporarily ruled out; ② Early diagnosis and dynamic monitoring of DIC; ③ Identification of cerebral infarction.
2. Thrombolytic therapy monitoring and evaluation (VTE anticoagulant therapy monitoring) showed a significant increase in D-dimer and FDP under the action of thrombolytic drugs. When the thrombus was completely dissolved, D-dimer and FDP in the plasma rapidly decreased and returned to normal after 2 weeks. Therefore, dynamic detection of D-dimer and FDP concentration changes has significant clinical value in monitoring the efficacy and safety of thrombolytic drugs.
3. Monitoring of Thrombosis Risk and Assessment of Disease Condition (Determination of Fibrinolytic Hyperactivity)
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