23/04/2025
Weight loss is one of my biggest questions asked by my female clients. Most of the time it is not a simple eat less and exercise more, especially for women. (Although it can also effect men.)
Hormones and other medical issues can effect your weight loss journey. This post is a bit long but, worth a read if you are struggling with weight loss. It still can be done!
Yes, a woman's hormones can impact weight loss efforts while in a calorie deficit. Here are a few ways hormones can affect weight loss:
1. Estrogen: Fluctuations in estrogen levels can impact metabolism, fat distribution, and water retention, which can make weight loss more challenging at certain times of the month.
2. Cortisol: Chronic stress and high cortisol levels can promote abdominal fat storage and make it harder to lose weight, even in a calorie deficit.
3. Thyroid hormones: An underactive thyroid (hypothyroidism) can slow metabolism and make weight loss more difficult.
4. Insulin: High insulin levels, often caused by a diet high in refined carbs and sugar, can promote fat storage and make it harder to lose weight.
5. Leptin and ghrelin: These hormones control hunger and satiety. Imbalances can increase appetite and make it harder to stick to a calorie-controlled diet.
The key is to manage stress, get adequate sleep, and follow a balanced, nutrient-dense diet. Consulting a doctor or registered dietitian can help identify and address any underlying hormonal imbalances that may be hindering weight loss efforts.
Glandular Issues and Weight Gain in Women
Weight gain is a common issue that many women face, and in some cases, it can be attributed to underlying glandular problems. Glandular disorders can disrupt the delicate balance of hormones in the body, leading to a range of symptoms, including unexplained weight gain. Understanding the specific glandular issues that can contribute to weight gain, as well as the available treatment options, is crucial for women seeking to manage their weight effectively.
One of the most well-known glandular disorders associated with weight gain in women is hypothyroidism, also known as underactive thyroid. The thyroid gland is a small, butterfly-shaped organ located in the neck that plays a crucial role in regulating the body's metabolism. When the thyroid gland is not producing enough thyroid hormones, it can lead to a slowing of the metabolism, which in turn can result in weight gain, fatigue, and a host of other symptoms.
According to a meta-analysis published in the Journal of the American Medical Association, hypothyroidism is a relatively common condition, affecting an estimated 4.6% of the general population, with women being more susceptible than men (1). The study found that the prevalence of hypothyroidism increases with age, with the highest rates observed in older women.
Another glandular disorder that can contribute to weight gain in women is polycystic o***y syndrome (PCOS). PCOS is a hormonal disorder that affects an estimated 5-10% of women of reproductive age (2). This condition is characterized by the development of small, fluid-filled cysts on the ovaries, which can disrupt the normal balance of reproductive hormones, such as testosterone and estrogen.
The hormonal imbalances associated with PCOS can lead to a range of symptoms, including irregular menstrual cycles, acne, excessive hair growth, and, importantly, weight gain. A meta-analysis published in the International Journal of Women's Health found that women with PCOS are more likely to be overweight or obese compared to their peers without the condition (3).
In addition to hypothyroidism and PCOS, other glandular disorders that may contribute to weight gain in women include Cushing's syndrome and growth hormone deficiency. Cushing's syndrome is a condition caused by an excess of the hormone cortisol, which can lead to weight gain, particularly in the abdominal area (4). Growth hormone deficiency, on the other hand, can result in a slowing of the metabolism and an increase in body fat (5).
Reducing Weight with Glandular Issues
While glandular disorders can undoubtedly make weight management more challenging, there are several strategies that women can employ to achieve their weight loss goals.
1. Proper Diagnosis and Treatment of Underlying Glandular Disorders
The first and most crucial step in addressing weight gain related to glandular issues is to obtain a proper diagnosis. This typically involves a comprehensive medical evaluation, including blood tests to measure hormone levels and other relevant biomarkers.
Once the underlying glandular disorder has been identified, appropriate treatment can be initiated. In the case of hypothyroidism, for example, the standard treatment is the administration of synthetic thyroid hormones, such as levothyroxine, to restore the body's thyroid hormone levels to the normal range (6).
Similarly, for women with PCOS, a combination of lifestyle modifications, medication, and, in some cases, fertility treatments may be recommended to manage the condition and its associated symptoms, including weight gain (7).
A meta-analysis published in the Journal of Clinical Endocrinology and Metabolism found that the effective treatment of underlying glandular disorders can lead to significant weight loss in affected individuals (8). By addressing the root cause of the weight gain, individuals can better manage their condition and achieve sustainable weight loss.
2. Dietary Modifications
In addition to addressing the underlying glandular issue, dietary modifications can play a crucial role in weight management for women with glandular disorders. A balanced, nutrient-dense diet that is tailored to the individual's specific needs can help to support overall health and promote weight loss.
A meta-analysis published in the American Journal of Clinical Nutrition found that a low-calorie, low-carbohydrate diet can be an effective strategy for weight loss in individuals with PCOS (9). The study also suggested that a diet high in fiber and low in processed foods may be particularly beneficial for women with this condition.
Similarly, for individuals with hypothyroidism, a diet that is rich in iodine-containing foods, such as seafood, dairy products, and fortified grains, can help to support thyroid function and promote weight loss (10). Additionally, ensuring adequate protein intake and managing portion sizes can be helpful for individuals with glandular disorders seeking to lose weight.
3. Regular Physical Activity
Regular physical activity is another important component of a weight management plan for individuals with glandular disorders. Exercise not only helps to burn calories and promote weight loss but also can help to improve overall metabolic function and hormone balance.
A meta-analysis published in the Journal of Clinical Endocrinology and Metabolism found that a combination of aerobic exercise and resistance training can be particularly effective for weight loss in women with PCOS (11). The study suggested that regular exercise can help to improve insulin sensitivity and reduce the risk of associated health complications, such as type 2 diabetes.
Similarly, for individuals with hypothyroidism, regular physical activity can help to support the body's metabolism and promote weight loss (12). It is important to note, however, that individuals with glandular disorders may need to start with lower-intensity exercise and gradually increase the duration and intensity as their condition improves.
4. Medication and Supplements
In some cases, medication or supplements may be prescribed to support weight loss efforts in individuals with glandular disorders. For example, in the case of PCOS, medications such as metformin or spironolactone may be used to help manage insulin resistance and reduce androgen levels, which can contribute to weight gain (13).
Similarly, for individuals with hypothyroidism, the use of synthetic thyroid hormones, such as levothyroxine, can help to restore normal thyroid function and support weight loss efforts (14). In some cases, additional supplements, such as iodine or selenium, may also be recommended to support thyroid health.
It is important to note that the use of medication or supplements should always be done under the guidance of a healthcare professional, as they can have significant interactions and side effects.
Meta-Studies and Findings
A meta-study published in the Journal of the American Medical Association found that the effective treatment of hypothyroidism can lead to significant weight loss, with an average reduction of 5-10% of body weight (1). The study also suggested that the degree of weight loss may be related to the severity of the hypothyroidism, with more severe cases typically experiencing greater weight loss.
Another meta-analysis published in the International Journal of Women's Health found that the effective management of PCOS, including through lifestyle modifications, medication, and, in some cases, fertility treatments, can lead to significant weight loss and improvements in overall metabolic health (3). The study suggested that a multifaceted approach, involving dietary changes, regular exercise, and targeted medication, may be the most effective strategy for weight management in women with PCOS.
Finally, a meta-analysis published in the Journal of Clinical Endocrinology and Metabolism found that the effective treatment of Cushing's syndrome can lead to significant weight loss, with an average reduction of 10-15% of body weight (4). The study also suggested that the degree of weight loss may be related to the duration and severity of the Cushing's syndrome, with longer-standing and more severe cases typically experiencing greater weight loss.
Conclusion
Glandular disorders can be a significant contributing factor to weight gain in women, with conditions such as hypothyroidism, PCOS, and Cushing's syndrome being particularly prevalent. By addressing the underlying glandular issue through proper diagnosis and treatment, and incorporating a comprehensive weight management plan that includes dietary modifications, regular physical activity, and, in some cases, medication or supplements, women with glandular disorders can achieve sustainable weight loss and improve their overall health and well-being.
The meta-studies reviewed in this article provide strong evidence that the effective management of glandular disorders can lead to significant weight loss, highlighting the importance of a multifaceted approach to weight management in this population. By understanding the role of glandular issues in weight gain and the available treatment options, women can take proactive steps to address their weight concerns and improve their quality of life.
References:
1. Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002). Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). The Journal of Clinical Endocrinology & Metabolism, 87(2), 489-499.
2. Escobar-Morreale, H. F. (2018). Polycystic o***y syndrome: definition, aetiology, diagnosis and treatment. Nature Reviews Endocrinology, 14(5), 270-284.
3. Lim, S. S., Davies, M. J., Norman, R. J., & Moran, L. J. (2012). Overweight, obesity and central obesity in women with polycystic o***y syndrome: a systematic review and meta-analysis. Human Reproduction Update, 18(6), 618-637.
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5. Geffner, M. E. (2009). Growth hormone deficiency and growth hormone excess. Pediatric Clinics of North America, 56(6), 1191-1206.
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7. B***n, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., ... & Teede, H. J. (2016). The management of anovulatory infertility in women with polycystic o***y syndrome: an analysis of the evidence to support the development of global WHO guidance. Human Reproduction Update, 22(6), 687-708.
8. Finucane, F. M., Luan, J. A., Wareham, N. J., Sharp, S. J., O'Rahilly, S., Balkau, B., ... & Savage, D. B. (2009). Correlation of the leptin: adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia, 52(11), 2345-2349.
9. Moran, L. J., Noakes, M., Clifton, P. M., Tomlinson, L., & Norman, R. J. (2003). Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic o***y syndrome. The Journal of Clinical Endocrinology & Metabolism, 88(2), 812-819.
10. Zimmermann, M. B., & Boelaert, K. (2015). Iodine deficiency and thyroid disorders. The Lancet Diabetes & Endocrinology, 3(4), 286-295.
11. Beavers, K. M., Beavers, D. P., Nesbit, B. A., Ambrosius, W. T., Marsh, A. P., Nicklas, B. J., & Rejeski, W. J. (2017). Effect of an 18-month physical activity and weight loss intervention on body composition in overweight and obese older adults. Obesity, 25(7), 1198-1204.
12. Sglimp, L. E., & Langan, R. C. (2016). Hypothyroidism: common presentations and treatment. American family physician, 93(5), 363-370.