RG Pediatric Hematology and Oncology

15/02/2022

Kinderkrebstag: https://www.hessenschau.de/tv-sendung/kinderkrebstag-heilungschancen-immer-besser,video-165656.html

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03/02/2022

We are very happy that our article describing the molecular basis for the dual differentiation block in megkaryoblastic leukemia associated with trisomy 21 now appeared in BLOOD. Oriol Alejo Valle found with ARID3A a new regulator of megakaryopoiesis that is deregulated in megkaryoblastic leukemia.

Given the plasticity of hematopoietic stem and progenitor cells, multiple routes of differentiation must be blocked in the the pathogenesis of acute m…

17/01/2022

Juliane Grimm and Raj Bhayadia from our team made a big step towards targeted therapies in pediatric myeloid leukemia. Based on our previous work showing the key role of two altered processes in the development of myeloid leukemia in children with Down syndrome, they designed and preclinically tested a strategy to specifically interfere with those alterations in leukemic cells. The strategy can be extended to other malignanicies with similar alterations.

https://www.biorxiv.org/content/10.1101/2022.01.14.476342v1

Children with Down syndrome (DS) are predisposed to developing megakaryoblastic leukemia (ML-DS) and often experience severe toxicities from chemotherapy, highlighting the need for targeted therapies with beneficial risk profiles. The genomic landscape of ML-DS is characterized by a combination of m...

13/11/2021

Congratulations Michelle, well done

21/10/2021

We are recruiting new members to our growing team in Frankfurt

https://www.kgu.de/fileadmin/redakteure/Klinikum/Dezernat2/Abteilung_2.1/Stellen/Stellen_2021/2021_10_12_PhD_KKJM_engl.Version_533-2021.pdf

21/10/2021

We are recruiting new members to our growing team in Frankfurt!
https://www.kgu.de/fileadmin/redakteure/Klinikum/Dezernat2/Abteilung_2.1/Stellen/Stellen_2021/2021_10_12_PhD_KKJM_engl.Version_533-2021.pdf

26/08/2021

News from the clinical part of the group. Sina Ne and colleagues published the guidlines for the diagnostic and treatment of myeloid leukemias in children with Down syndrome. We hope that the guidelines will be helpful for physician world-wide caring about these children

https://pubmed.ncbi.nlm.nih.gov/34407551/

Children with Down syndrome are at a high risk of developing transient abnormal myelopoiesis (TAM; synonym: TMD) or myeloid leukemia (ML-DS). While most patients with TAM are asymptomatic and go into spontaneous remission without a need for therapy, around 20% of patients die within the first six mo...

10/08/2021

Another pre-publication from our lab! By probing MYNRL15, a pan-myeloid leukemia dependency identified from an lncRNA-based CRISPRi screen, we uncovered a new subclass of functional genetic elements, which we termed CTCF-enriched lncRNA loci (C-LNC).
https://www.researchsquare.com/article/rs-727909/v1

Research Square is a preprint platform that makes research communication faster, fairer, and more useful.

14/07/2021

05/05/2021

Congratulations to Sina Al on an excellent medical thesis! 🎓💐

27/04/2021

Our most recent work is is now prepublished. Oriol Alejo describes the molecular basis for the dual differentiation block in megkaryoblastic leukemia associated with trisomy 21 and found a new regulator of megakaryopoiesis:
https://biorxiv.org/cgi/content/short/2021.04.26.440795v1

Given the plasticity of hematopoietic stem/progenitor cells, multiple routes of differentiation must be blocked during acute myeloid leukemia pathogenesis - the molecular basis of which is incompletely understood. Here we report that post-transcriptional repression of transcription factor ARID3A by....