Dynamic42 GmbH

27/08/2025

⏰ Last Chance to Register!
Our step-by-step guide on how to develop your own organ model is happening TOMORROW!

📅 Date: 28 August 2025
🕓 Time: 4 PM CEST (7 AM PDT I 10 AM EDT I 11 PM JST)
🎤 Speakers: Joanna & Katja | 🎙️ Moderator: Juliane

Don’t miss this webinar, designed to help you develop your own organ model from scratch.

Here’s why you should join:
/ Detailed step-by-step guide to start your own organ model
/ Focus on practical lab applications—not just theory
/ Time-saving strategies to adopt the technology efficiently

👉 Register Here: https://zurl.co/23Kol

This webinar provides a step-by-step guide on conceptual & technical considerations to developing organ-on-chip models.

26/08/2025

Key features part VI – Multicellular Tissues

Organ-on-chip technology provides tremendous flexibility and potential for adaptations tailored specifically to the scope and needs of a scientific study.
Models can be scaled up from one to multiple cell types included in microphysiological settings. Increasing complexity provides maximum control of experimental design and settings. Additionally, single cell types can be easily excluded to assess their impact within the scope of your research study.

19/08/2025

Tired of generic introductions to organ-on-chip technology?
Our upcoming webinar isn’t just another overview.

Here’s why you should join:
/ Detailed step-by-step guide to start your own organ model
/ Focus on practical lab applications—not just theory
/ Time-saving strategies to adopt the technology efficiently

Take the guesswork out of organ-on-chip research.
📅 Mark your calendar for 28 August at 4 PM CEST (7 AM PDT I 10 AM EDT I 11 PM JST)

👉 Register Here: https://zurl.co/lXfm0

This webinar provides a step-by-step guide on conceptual & technical considerations to developing organ-on-chip models.

14/08/2025

Key features part V – Stretch & Strain

Our human body is in motion all the time and so is every tissue, most prominently blood vessels, muscles, the lung and the intestine. With organ-on-chip technology it is possible to apply stretch and strain onto the cells which in turn influences cellular behavior. This can be achieved via the application of flow or a direct mechanical manipulation of the tissue by deformation of biochip components.
Our human cells sense these forces via the mechanostimulatory complex – a crucial cellular sensing complex influencing various signaling pathways. This important “cellular tool” that switches on human biology is entirely neglected in standard in vitro approaches including in vitro testing.

05/08/2025

Upcoming Live Webinar: A step-by-step guide on how to develop your own organ on chip

Are you considering organ-on-chip technology for your research in addition or instead of traditional cell culture or animal methods? But you are concerned that the technology is too complex and would take a significant amount of time to adopt?

Then this webinar is for you!

Join us for an exclusive step-by-step guide on how to develop your own organ-on-chip model!

📅 Date: 28 August 2025
🕓 Time: 4 PM CEST (7 AM PDT I 10 AM EDT I 11 PM JST)
🎤 Speakers: Joanna & Katja
🎙️ Moderator: Juliane

In this webinar, we’ll cover:
/ Conceptual & technical considerations
/ Biological insights & practical steps
/ Validation techniques and more!

👉 Register Here: https://zurl.co/VkO8Z

This webinar provides a step-by-step guide on conceptual & technical considerations to developing organ-on-chip models.

31/07/2025

Key features part IV – Molecular Gradients

Molecular patterns shape biological changes and responses within our human body. Organ-on-Chip technology enables easy application of molecular gradients. Controlled microfluidic perfusion patterns can modulate lateral distribution, especially in vascular tissues. The complex layering of cells, formation of tissue-tissue interfaces, and biochip geometry can govern gradients throughout tissues.

29/07/2025

Key features part III – Microorganism

Complex organ models allow for the integration of a microbiome or pathogens to enable the establishment of complex disease and infection models.

22/07/2025

Key features part II – Immunocompetence

The immune system is a critical component of the human body, playing a vital role in protecting against infections, eliminating diseased cells, and maintaining tissue homeostasis. Via integration of resident and circulating immune cells, organ models can replicate the cellular complexity of the human immune system.

15/07/2025

Key features part I – Blood Flow

Organ models are cultivated on biochips which are connected to microfluidic pumps. Through this connection, different flow patterns (pulsatile and laminar) such as in the healthy human body can be achieved. This tissue specific blood flow enables physiological developments of cell cultures like in vivo.

Watch medium flow through one of our biochips starting from a reservoir, going through the channels into the biochip chambers with an epithelial and endothelial cell layer.

08/07/2025

Organ-on-chip models - how do they work?

Organ models integrate essential cellular components of human organs with biomechanical forces, combining tissue culture with microfluidics.

Cells are cultured on a biochip with parallel channels—typically one upper and one lower—separated by a porous membrane. This setup allows the cultivation of organ-specific tissues, such as endothelial and epithelial layers, and supports vital functions like nutrient transport, cell communication, and physiological responses.

The biochips are connected to peristaltic pumps that mimic biomechanical forces like blood flow, peristalsis, or lung breathing. This dynamic environment provides more physiological tissue growth compared to traditional 2D cultures and enables studies on immune responses and drug delivery.

03/07/2025

What is the difference between a microphysiological system and organ-on-chip?

Classification: OoC is a specific type of MPS
Technology: OoC happens on chip, MPS doesn’t have to

MPS are:
Microphysiological systems are in vitro models that replicate tissue, organ, or organ system physiology at a miniature scale. These systems focus on tissue architecture, biological function, nutrition, and biomechanical stimulation.

OoC are:
Organ-on-chip technology replicates the physiological environment of a single tissue or organ using microfluidic devices with living engineered organ substructures. It aims to replicate organ dynamics and functionality in both physiological and pathophysiological stages, utilising biomechanical stimulation.

Main difference here is: MPS does not necessarily depend on the biomechanical stimulation. Therefore, complex organized tissues in a well plate can also be an MPS.

11/06/2025

Missed ? Here is a quick walkthrough of the beautiful venue.

You can meet us at booth #202 if you are looking for:
/ Biochips without PDMS for low drug adsorption
/ High sample recovery for end-point analysis
/ Infections models for all the microbes out there
/ Technology that doesn’t require capital investment & fits seamlessly into your lab’s workflow
/ Cancer models that model metastasis, angiogenesis, 3D tumour structure, the TME, immune invasion & dynamic drug delivery