Dynamic42 GmbH

05/08/2025

Upcoming Live Webinar: A step-by-step guide on how to develop your own organ on chip

Are you considering organ-on-chip technology for your research in addition or instead of traditional cell culture or animal methods? But you are concerned that the technology is too complex and would take a significant amount of time to adopt?

Then this webinar is for you!

Join us for an exclusive step-by-step guide on how to develop your own organ-on-chip model!

📅 Date: 28 August 2025
🕓 Time: 4 PM CEST (7 AM PDT I 10 AM EDT I 11 PM JST)
🎤 Speakers: Joanna & Katja
🎙️ Moderator: Juliane

In this webinar, we’ll cover:
/ Conceptual & technical considerations
/ Biological insights & practical steps
/ Validation techniques and more!

👉 Register Here: https://zurl.co/VkO8Z

This webinar provides a step-by-step guide on conceptual & technical considerations to developing organ-on-chip models.

31/07/2025

Key features part IV – Molecular Gradients

Molecular patterns shape biological changes and responses within our human body. Organ-on-Chip technology enables easy application of molecular gradients. Controlled microfluidic perfusion patterns can modulate lateral distribution, especially in vascular tissues. The complex layering of cells, formation of tissue-tissue interfaces, and biochip geometry can govern gradients throughout tissues.

29/07/2025

Key features part III – Microorganism

Complex organ models allow for the integration of a microbiome or pathogens to enable the establishment of complex disease and infection models.

22/07/2025

Key features part II – Immunocompetence

The immune system is a critical component of the human body, playing a vital role in protecting against infections, eliminating diseased cells, and maintaining tissue homeostasis. Via integration of resident and circulating immune cells, organ models can replicate the cellular complexity of the human immune system.

15/07/2025

Key features part I – Blood Flow

Organ models are cultivated on biochips which are connected to microfluidic pumps. Through this connection, different flow patterns (pulsatile and laminar) such as in the healthy human body can be achieved. This tissue specific blood flow enables physiological developments of cell cultures like in vivo.

Watch medium flow through one of our biochips starting from a reservoir, going through the channels into the biochip chambers with an epithelial and endothelial cell layer.

08/07/2025

Organ-on-chip models - how do they work?

Organ models integrate essential cellular components of human organs with biomechanical forces, combining tissue culture with microfluidics.

Cells are cultured on a biochip with parallel channels—typically one upper and one lower—separated by a porous membrane. This setup allows the cultivation of organ-specific tissues, such as endothelial and epithelial layers, and supports vital functions like nutrient transport, cell communication, and physiological responses.

The biochips are connected to peristaltic pumps that mimic biomechanical forces like blood flow, peristalsis, or lung breathing. This dynamic environment provides more physiological tissue growth compared to traditional 2D cultures and enables studies on immune responses and drug delivery.

03/07/2025

What is the difference between a microphysiological system and organ-on-chip?

Classification: OoC is a specific type of MPS
Technology: OoC happens on chip, MPS doesn’t have to

MPS are:
Microphysiological systems are in vitro models that replicate tissue, organ, or organ system physiology at a miniature scale. These systems focus on tissue architecture, biological function, nutrition, and biomechanical stimulation.

OoC are:
Organ-on-chip technology replicates the physiological environment of a single tissue or organ using microfluidic devices with living engineered organ substructures. It aims to replicate organ dynamics and functionality in both physiological and pathophysiological stages, utilising biomechanical stimulation.

Main difference here is: MPS does not necessarily depend on the biomechanical stimulation. Therefore, complex organized tissues in a well plate can also be an MPS.

11/06/2025

Missed ? Here is a quick walkthrough of the beautiful venue.

You can meet us at booth #202 if you are looking for:
/ Biochips without PDMS for low drug adsorption
/ High sample recovery for end-point analysis
/ Infections models for all the microbes out there
/ Technology that doesn’t require capital investment & fits seamlessly into your lab’s workflow
/ Cancer models that model metastasis, angiogenesis, 3D tumour structure, the TME, immune invasion & dynamic drug delivery

10/06/2025

Last evening our PhD student Amélie presented her work at the 3-min-thesis competition.

She talked about "A cancer-on-chip model to monitor the impact of the TME on immune cells".

We think she did brilliantly…but see for yourself

Btw from today you can meet us at booth #202

29/05/2025

In the quest for her master thesis Noreen stumbled over models for infection research on Aspergillus fumigatus. The topic immediately intrigued her and she is working on it to date.

27/05/2025

With the end of approaching we like to summarize our learnings and highlights from this month.

At the end of April, our team attended 2025. The team enjoyed their stay in Chicago very much (as you might be able to tell from the picture 😀)

AACR highlighted advancements in cancer biology and treatment strategies, including next-generation therapeutics like ADCs, T-cell engager antibodies, and small molecule inhibitors. Significant progress was also made in tumor microenvironment research, AI-driven oncology, and emerging cancer technologies.

The tumour microenvironment is a topic of great interest in the academic community, particularly due to its ability to help tumors evade the immune system.

Deipenbrock et al. recently published a PDAC-on-chip modelling the tumour microenvironment, that uses the Dynamic42 BC003 biochip as a basis. In a collaboration we developed a model that allows researchers to study immune cell infiltration and dynamic drug application.

Combining 3D spheroids or organoids with on-chip culture stands out as a particularly valuable tool for cancers models. Spheroid-on-chip models combine biomechanical stimulation, with the spatially controlled interaction of a tumor and its microenvironment

We are excited to watch the results to come from such comprehensive in vitro models for cancer research in the next year.

17/05/2023

👨‍🔬 Would you like to develop complex organ models in biochip format? Or would you like to contribute with your expertise in another field to our young company? Beyond, challenges different than in academic settings are waiting for you to master.
We have exciting positions available as technical assistants, scientists or in procurement and shipping.

🤝 Expect an interesting, varied field of activity in an innovative and internationally networked biotech company. We believe in future driven innovations in science to reduce animal testing and are committed to transform the processes of drug development and establish the organ-on-chip technology.

If you are ready to make a difference in research and develop approaches for e.g. future medicine, join us at Dynamic42!

📰 Get more information here: https://dynamic42.com/career/

We are hiring! Apply now to join our team and revolutionize the cell culture market! We stand for animal-free and sustainable drug development ←