Dynamic42 GmbH

27/05/2026

How can we build more predictive and human-relevant in vitro models for disease and cancer research?
We are excited to present our latest work in cancer-on-chip modeling and tissue barrier analysis at MPS World Summit.

From non-invasive monitoring of intestinal barrier integrity to recreating the complex pancreatic tumor microenvironment with immune cell modulation, our posters highlight innovative in vitro platforms designed to improve disease modeling, drug evaluation, and translational research.

Come visit our posters and connect with us today:

📍Poster #336: A non-invasive plug&play TEER system for real-time monitoring of cellular barrier dynamics in a 3D intestine-on-chip model (Japhette Kembou-Ringert, presented by Amélie Paillereau, 9:30 – 11:00 AM EDT)

Here we introduce a scalable and reproducible platform for real-time assessment of tissue barrier integrity with temporal resolution — enabling deeper insights into physiological and pathological processes without invasive handling.

📍 Poster #369: A dynamic micro-vascularized organ-on-chip model of pancreatic cancer reveals T cell exclusion and modulation (Thomas Sommermann, 3:15 – 4:45 PM), in collaboration with Alina Deipenbrock and Nicole Teusch from Heinrich-Heine-Universität Düsseldorf

Here we present our PDAC-on-chip model, recreating the tumor microenvironment and complex crosstalk between the tumor and its surrounding stroma. This platform provides a powerful tool for preclinical drug candidate evaluation while supporting alternatives to animal testing.

Looking forward to connect and exchange ideas on your organ-on-chip applications.

26/05/2026

Did you ever wonder how much oxygen cells are actually exposed to inside organ-on-chip models?
Oxygen plays a key role in metabolism, immune responses & disease progression — but it is also highly dynamic and difficult to monitor in real time.

Together with GmbH, we have developed the first fully integrated organ-on-chip technology with non-invasive real-time oxygen measurement.

Want to see our oxygen sensor technology in action? At MPS World Summit we are hosting a live demo of our DynamicOrgan® O₂-Sensor System.

☕ The demo will take place daily during coffee breaks and poster sessions.

Come by at booth 515/517 to discuss your questions with our experts Japhette Kembou-Ringert, Thomas Sommermann, Martin Raasch, Nadia Savelyeva (Axonlab) and Stefanie Fuchs (PyroScience) — and while stopping by, pick up a limited event bag. 🛍️

🔗 Demo Schedule: https://zurl.co/MBb4J

26/05/2026

Our team has arrived in Washington, DC and we’re excited to exhibit at !

Here is what you can look forward to:

🔹Today (May 26): Join Tom and Amélie to see TEER & oxygen measurement in action and get hands-on experience with our biochips during our educational session
🔹 Tomorrow (May 27): Visit our posters to explore integrated TEER measurement for organ-on-chip and our PDAC-on-chip model
🔹 Every day: Stop by at booths 515/517 for a live demo of our oxygen sensor system together with GmbH

Excited to connect and exchange ideas over the coming days!

22/05/2026

How do you truly understand tissue dynamics in organ-on-chip systems without real-time data?

At MPS World Summit we are hosting an educational workshop exploring how integrated live readouts enable continuous monitoring of tissue function over time. This allows monitoring how tissues develop, respond, deteriorate, or recover – all within the same experiment.

The workshop focuses on two key real-time, non-invasive readouts: TEER and oxygen measurements. Participants will learn how these methods are used to assess barrier integrity and tissue fitness in organ-on-chip models, and gain practical experience with the Dynamic42 biochips, including:
• biochip handling
• cell seeding
• perfusion setup
• performing TEER and oxygen readouts.

Intersted in learning how live monitoring can enhance your organ-on-chip workflows? Joint Japhette Kembou-Ringert and Thomas Sommermann to discuss your use cases and questions.

21/05/2026

Webinar season is in full swing, and we’re excited to invite you to our next session!

Join us on June 18, 2026, at 4 PM CET for a joint webinar by Dynamic42 and EPO Experimental Pharmacology & Oncology Berlin Buch: “Advanced BBB on Chip Models for Brain Cancer Research.” We’ll discuss how physiologically relevant BBB models can help investigate brain tumors, brain metastasis, and drug transport into the brain.

🚀 Speakers: Amélie Paillereau (Dynamic42), Michelle Zimmer (EPO), Dr. Thomas Sommermann (Dynamic42), Dr. Martin Raasch (Dynamic42), Dr. Jens Hoffmann (EPO)
🎙️ Featuring: research talks + expert panel discussion on current bottlenecks and translational opportunities in brain cancer research

Within this webinar:
/ How advanced BBB on Chip models are established and optimized for translational research
/ Applications in glioma and other brain tumor entities: tumor–BBB interactions and barrier function
/ Drug transport and efficacy testing: evaluating candidates in a physiologically relevant BBB setting
👉 Register here: https://zurl.co/cTUtW

19/05/2026

In IBD, loss of butyrate during dysbiosis may weaken mucosal defense against C. albicans. With a Colitis-on-Chip the authors showed butyrate strengthens barrier integrity & boosts macrophage antifungal defense while limiting inflammatory damage. Summary: https://zurl.co/tJoCd

13/05/2026

Two weeks until . What you shouldn’t miss:
1️⃣ Educational Workshop: Perform TEER/O₂ live readouts in Dynamic42 biochips
2️⃣ Live demo with PyroScience: Come to booth #515 to see our O₂ sensor system in action.
3️⃣ Posters: TEER for gut-on-chip + PDAC-on-chip

12/05/2026

What makes the DynamicOrgan® TEER-Sensor Kit different to existing solutions?

👉 Learn more about the DynamicOrgan® TEER-Sensor Kit here: https://zurl.co/VV0mt

11/05/2026

A microbiota-derived metabolite, a human colitis-on-chip, and a new angle on IBD barrier repair

In a new paper published by in Frontiers in Immunology the authors showed in a human colitis-on-chip that physiological lithocholic acid meaningfully reduced colitis-like damage by maintaining villus morphology, improving the barrier, and restoring epithelial proliferation, largely via FXR signaling.

It’s a strong example of how organ-on-chip models integrating epithelium, endothelium, and macrophages under flow, can capture multi-compartment effects that are invisible in simple monocultures and are difficult to dissect in animals.

Congratulations to Tim Kaden, Manuel Allwang, Johannes Stallhofer, Katja Graf, Martin Raasch and Alexander S. Mosig on this recent publication!

Read the article here: https://zurl.co/ZQVyF

07/05/2026

[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] Beyond endpoints - Real-time insights into barrier dynamics with TEER in organ-on-chip

This blog delves into various methods used to investigate barrier permeability in in vitro models, providing a comparative analysis based on the type of read-out, suitability for long-term and real-time measurements, and reproducibility.

Read it here: https://zurl.co/2IDch

This blog compares different methods for assessing barrier permeability in in vitro models addressing limitations of traditional endpoint assays.

29/04/2026

Connect with us at Europe in Prague.

As organ-on-chip technology continues to advance, it is reshaping how complex biological systems are studied. Meet Wolfgang and Knut to discuss how our solutions can improve pre-clinical decision making and accelerate workflows.