Dynamic42 GmbH

Dynamic42 GmbH Kontaktinformationen, Karte und Wegbeschreibungen, Kontaktformulare, Öffnungszeiten, Dienstleistungen, Bewertungen, Fotos, Videos und Ankündigungen von Dynamic42 GmbH, Winzerlaer Straße 2, Jena.

We de­velop nov­el, three-di­men­sion­al, hu­man or­gan mod­els (so-called or­gan-on-chip tech­nol­o­gy) for pre­clin­i­cal re­search and de­vel­op­ment as well as for test­ing novel phar­ma­ceu­ti­cal prod­ucts, chem­i­cals and food ad­di­tives.

Closing the gap in brain cancer research togetherWe are excited to announce a strategic collaboration between Dynamic42 ...
08/04/2026

Closing the gap in brain cancer research together

We are excited to announce a strategic collaboration between Dynamic42 and Experimental Pharmacology & Oncology Berlin-Buch GmbH to tackle one of the biggest challenges in brain cancer research: the lack of human-relevant preclinical models.

By combining Dynamic42’s organ-on-chip technology with EPO’s translational oncology expertise and patient-derived tumor models, we aim to improve the translational relevance of preclinical data—starting with glioblastoma and the blood–brain barrier (BBB).

Our joint goal:

/ Generate more human-relevant insights early in drug development by combining advanced in vitro and in vivo approaches
/ Reduce late-stage failure risks
/ Support biology-driven research and the 3Rs principles

👉 Learn more in this press release: https://zurl.co/4yiOp

We are proud to introduce our results from this joint project at in San Diego from April 19-22.

Where to meet us:
📌 Evening Reception hosted by EPO & Dynamic42: April 19, starting from 6 p.m. PDT at The East Village Brewing Company
📌 Poster #3401, April 20, 2-5 p.m. PDT (Session In Vitro Models 1: 2D and 3D, Section 28, Board 6)
Modelling the multicellular blood-brain barrier with a PDX-derived glioblastoma microenvironment: comparing human and mouse biochip systems for tumor heterogeneity and drug response (Amélie Paillereau, in collaboration with EPO)

“Not affiliated with or endorsed by AACR.”

Normoxia, Physioxia, Hypoxia: What’s the Difference?Most in vitro studies still use atmospheric oxygen (~21%). But human...
07/04/2026

Normoxia, Physioxia, Hypoxia: What’s the Difference?

Most in vitro studies still use atmospheric oxygen (~21%). But human tissues rarely experience anything close to that level.

Here’s a quick breakdown:

1️⃣ Normoxia

Atmospheric oxygen levels used in standard labs. Convenient - but rarely physiological.

2️⃣ Physioxia
The oxygen levels tissues actually experience in the body.
Often between 1-7 %, depending on the organ.

➡️ More relevant for modeling real biology.

3️⃣ Hypoxia
Reduced oxygen availability.
A hallmark of tumors, inflamed tissues, ischemia, or chronic disease.

➡️ Drives metabolic rewiring, immune modulation & therapy resistance.

4️⃣ Severe hypoxia / anoxia

Extremely low to absent oxygen - critical in stroke, wound healing defects, or necrotic tumor cores.

Understanding these oxygen regimes is essential to interpreting cellular behavior and designing physiologically accurate in vitro models.

02/04/2026

How does the TEER measurement work inside the DynamicOrgan® TEER-Sensor Biochip?

Listen to Tim explain the technology behind our newest Kit in the DynamicOrgan® Product family.

Ever wondered how scientists assess the integrity of cellular barriers? Historically, researchers have relied on endpoin...
31/03/2026

Ever wondered how scientists assess the integrity of cellular barriers?

Historically, researchers have relied on endpoint assays, such as permeability measurements, to assess barrier integrity. However, for a more dynamic evaluation, scientists can utilize the Trans-Epithelial/ Endothelial Electrical Resistance (TEER) assay.

What is TEER?

TEER quantifies the barrier integrity of cell monolayers by measuring electrical resistance across them. It's a powerful tool for evaluating the function of epithelial and endothelial barriers, crucial in organs like the gut, lungs, and brain.

Why is it useful?

A trademark of TEER assays is that they can measure the electrical resistance of living cells label-free which makes it an excellent technique to monitor the cellular barrier integrity.

How does it work?

TEER values increase upon rising cell proliferation rates and formation of functional cell-cell junctional complexes resulting in maximum confluency of the cell layer.

Similarly, if TEER values decrease it can indicate a disturbance or damage of the barrier through injury, chemical exposure, or disease development.

At Dynamic42, we are inspired by how the and community continues to bring innovation forward - especially through th...
30/03/2026

At Dynamic42, we are inspired by how the and community continues to bring innovation forward - especially through the impressive contribution of young scientists.

As sponsor of the 3R LÄND Conference hosted by -Center Tübingen we were delighted to award our poster prize to Sean Scanlon Boyle for his outstanding presentation on the development of a porcine ex vivo eye model. Congratulations!

Advanced systems promise greater human relevance. But without understanding the oxygen levels and barrier functions wi...
25/03/2026

Advanced systems promise greater human relevance. But without understanding the oxygen levels and barrier functions within an organ model, the picture remains incomplete.

That’s why we’re excited to showcase our new DynamicOrgan® Sensor Kits for real-time barrier (TEER) and oxygen measurement at the 3R LÄND Conference hosted by -Center Tübingen.

Curious? Join Valentin and Martyn at booth 8 and experience a live demonstration of our solutions.

At ? Join our exhibitor-hosted session for a live demo of and measurement using our new DynamicOrgan® Sensor Kits a...
24/03/2026

At ? Join our exhibitor-hosted session for a live demo of and measurement using our new DynamicOrgan® Sensor Kits and discover how they enhance barrier integrity assessment in predictive toxicology.

📅 Mar 25, 10:45–11:45
📍 Room 24A

See you tomorrow!

24/03/2026

Follow the pink stickers! 🩷

Our team is all set up at ! Follow Anne to our booth #2037 to explore our solutions for more reliable toxicity testing and watch a live demo for and measurements on chip.

See you there! 👋

Our team is heading to San Diego to exhibit at & !We are excited to show how our technology helps enhance drug sc...
23/03/2026

Our team is heading to San Diego to exhibit at & !

We are excited to show how our technology helps enhance drug screening and reduces translational failures.

Additionally, we are showcasing our new solutions for real-time barrier (TEER) and oxygen measurement.

Curious? Join us at our exhibitor-hosted session on March 25 and get a firsthand look at our solutions in action during a live demo.

We are at 3R LÄND Conference! Replace, Reduce, Refine - at Dynamic42, we live the 3R principles by providing human relev...
23/03/2026

We are at 3R LÄND Conference!
Replace, Reduce, Refine - at Dynamic42, we live the 3R principles by providing human relevant models as alternatives to animal testing. Join us at booth 8 to learn how our solutions deliver robust and ethical drug and toxicity testing.

18/03/2026

Introducing the DynamicOrgan® TEER-Sensor Kit: Measure the integrity of cellular barriers in a dynamically perfused organ model

We’re excited to launch our solution for real-time, non-invasive monitoring of barrier integrity within an organ-on-chip model such as lung, gut or liver-on-chip.

What makes the DynamicOrgan® TEER-Sensor Kit different to existing solutions?

✅ Real-time, and long-term TEER measurement
Existing methods are mostly endpoint based

✅ Compatibility with on-chip imaging
TEER electrodes are semi-transparent

✅ Neglectable noise from electrode motion + non-invasive measurement method
Our electrodes are fixed to the biochip in contrast to existing technologies

✅ Quick set up & easy handling also for inexperienced users
All you need to do is connect the biochip via a cable to the tighTEER T-31 readout unit.

✅ Direct measurement inside the incubator
TEER measurements are temperature sensitive

👉 Learn more about the DynamicOrgan® TEER-Sensor Kit here: https://zurl.co/z9lVa

Meet Knut & Wolfgang at !Interested in the future of NAMs and Organ-on-Chip technologies? Knut is available for strateg...
17/03/2026

Meet Knut & Wolfgang at !

Interested in the future of NAMs and Organ-on-Chip technologies? Knut is available for strategic discussions on our company, our OoC technology, and potential collaboration opportunities.

Looking to identify synergies? Let’s connect.

Adresse

Winzerlaer Straße 2
Jena
07745

Telefon

+49 (0)3641 508 101

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