Actin dynamics in invasion and metastasis

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Actin dynamics in invasion and metastasis

Research group investigating actin reorganization processes in tumor invasion and metastasis with the goal to identify potential therapeutic targets.

Reorganization of the actin cytoskeleton underlies a wide range of biological processes from wound healing to tumor cell invasion. We investigate mechanisms of actin dynamics in invasion and metastasis of epithelial tumors (colon and bladder cancer) and Ewing's sarcoma. Therefore, we apply a wide methodological spectrum from histology and immunohistochemistry to protein biochemistry and in vitro/in vivo metastasis assays.

06/08/2015

Job offer: we are currently seeking for a doctoral candidate! Please check
http://klinikum.uni-muenster.de/index.php?id=3290&tx_ttnews%5Btt_news%5D=5321&cHash=5840dce55a171bb41511e0d85a92db25

Für das Gerhard-Domagk-Institut für Pathologie zum nächstmöglichen Zeitpunkt zunächst befristet auf 2 Jahre mit der Möglichkeit der Verlängerung eine/n

09/07/2015

Extramural funding, part II: we are happy to announce that our research activities on invasion mechanisms in pancreatic ductal adenocarcinoma (PDAC) will be supported for 2 years by the programme "Innovative Medizinische Forschung" of the University Hospital Münster!

02/07/2015

Extramural Funding! - we are very happy to announce that the "Manfred-Stolte-Stiftung für Gastroenterologische Pathologie" has decided to support our research activities on the radiation response of re**al cancer cells for the next 12 months. This will improve our understanding of how tumor cells defend themselves against radiation therapy, with the ultimate goal to target these defense mechanisms pharmaceutically. We will keep you updated!

31/03/2015

Publication update!
We are happy to announce three upcoming publications....moreover, three external funding proposals are currently under review. Keep your fingers crossed!

Steinestel J, Al Ghazal A, Arndt A, Schnöller TJ, Schrader M, Schrader AJ, Möller P, Steinestel K. Histologic subtype, p16INK4a expression patterns and human papillomavirus DNA in pe**le squamous cell carcinoma: associations with tumour aggressiveness and prognosis. BMC cancer: in press.

Arndt A, Kraft K, Wardelmann E, Steinestel K. Lack of association between membrane-type 1 matrix metalloproteinase (MT1-MMP) expression and clinically relevant molecular or morphologic tumor characteristics at the leading edge of invasive colore**al carcinoma. Biomed Res Int 2015 Mar 19. [Epub ahead of print]

Schnoeller TJ, Steinestel J, Steinestel K, Jentzmik F, Schrader AJ: Do preoperative serum C-reactive protein levels predict the definitive pathological stage in patients with clinically localized prostate cancer? Int Urol Nephrol 2015 Mar 19. [Epub ahead of print]

05/01/2015

CHD1 colore**al carcinoma cells (cell nuclei stained in blue in the left merged picture) express Abi1 protein (green, center) and degrade underlying matrix (red, right) as a prerequisite for tumor cell invasion (unpublished data).

Adresse

DomagkStr. 17
Münster
48149

Webseite

http://www.klinikum.uni-muenster.de/index.php?id=pathologie

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