Lichtensteiner Physiotherapie

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12/05/2022

Just published in European Spine Journal

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Gut-disc axis: A cause of intervertebral disc degeneration (IDD) and low back pain?

https://link.springer.com/article/10.1007/s00586-022-07152-8

According to the existing evidence, the microbiome could be an important factor for inducing and aggravating IDD through changing or regulating the outside and inside microenvironment of the intervertebral disc (IVD). Three potential mechanisms by which the gut microbiota can induce IDD and cause LBP are: (1) translocation of the bacteria across the gut epithelial barrier and into the IVD, (2) regulation of the mucosal and systemic immune system, and (3) regulation of nutrient absorption and metabolites formation at the gut epithelium and its diffusion into the IVD.

Figure: Gut-disc axis. Model of intestinal epithelial disruption signals that can regulate intervertebral disc degeneration. Gut microbes alter the intestinal microbial environment by modulating gut microbiota translocation and composition, increasing intestinal permeability and inflammation and modifying metabolites absorption. These changes can result in local and systemic responses that can cause IDD. A Pathogen displacement, B immune system modifications and C microbial metabolites production and cytokines

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