ᑭᕼᗩᖇᗰᗩᑕiᗩ ᐯEᖇᗪE

22/11/2020

Improvising over orchestra

08/11/2020

https://scitechdaily.com/covid-19-patient-zero-data-analysis-identifies-the-mother-of-all-sars-cov-2-genomes/

COVID-19 Patient Zero: Data Analysis Identifies the “Mother” of All SARS-CoV-2 Genomes

Temple researchers have identified the first genome to transmit the coronavirus. In the field of molecular epidemiology, the worldwide scientific community has been sleuthing to solve the riddle of the early history of SARS-CoV-2. Since the first SARS-CoV-2 virus infection was detected in Dece

30/10/2020

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Why it is so important to use Standardised Medicinal Herbs?

̈uter ̈n

05/09/2020

Pharmacia Viva (Farmacia Viva) is a project implemented in the Brazilian Healthcare system since the 80s to produce and make available medicinal herbal drugs and herbal finished products for pacients. They profit from high quality preparations to treat minor conditions to which the treatment with medicinal plants has been already validated. In Brazilia, the country capital, this project completed 30 years now. It has supported more then 300 thousand patients so far, and only the first semester of this year it produced more then 300 kg of herbal medicines for the community.

Governo do Distrito Federal

26/08/2020

Cannabis and CBD isn't some cure-all, miracle drug, but its health benefits aren't all fabricated. CBD can prove very useful in treating joint pain, arthritis, insomnia, and other conditions.

But as I often try to explain, cannabinoids and CBD products are not a Panacea (cure all) .

A new systematic review and meta analysis study shows that there is not enough evidence for the efficacy of CANNABIDIOIDS for the treatment of ANXIETY disorders.

As you can see, in most of studies a little difference is observed between the product and the placebo, but the data are very heterogenous among studies.

16/07/2020

Artificial Intelligence is slowly becoming part of R&D in the Pharma industry, but study shows there is still a long journey to fully incorporate AI in their structures.
Some of these companies have also in the portfolio phytomedicines, but very less is shown how their development and discovery will benefit from data science and AI.

The pharmaceutical business is perhaps the only industry on the planet, where to get the product from idea to market the company needs to spend about a decade, several billion dollars, and there is about 90% chance of from the time it takes from discovery to a marketed product may take a decade, ...

15/07/2020

14/07/2020

Are cured people immunized?

People answer differently to the virus regarding the production of memory antibodies. Most individuals cured from Covid-19 showed very low levels of antibodies, revealed study. There is not enough evidences cured people will not contract the virus again. It is therefore still strongly advised that cured people keep the same measures of higiene and contact distancing.

https://www.nature.com/articles/s41586-020-2456-9

During the COVID-19 pandemic, SARS-CoV-2 infected millions of people and claimed hundreds of thousands of lives. Virus entry into cells depends on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S). Although there is no vaccine, it is likely that antibodies will be essential for p...

20/06/2020

Se as medidas de distanciamento social se afrouxam quando o vírus ainda círcula amplamente pelo país, o pico de coronavírus poderá tardar muito mais do que fim de agosto.

Neste vídeo, o repórter Rafael Barifouse explica por que não dá para dizer que o Brasil chegou ao auge da epidemia de covid-19 – o que pesquisadores já preve...

02/06/2020

Amazonian tribe prepares 500-page encyclopedia of traditional medicine. Traditional knowledge matters!

En medio de la tragedia, chamanes se han unido para crear la enciclopedia de medicina tradicional de 500 páginas. En una de las grandes trage

26/05/2020

Revolução verde começa no quintal !

A bióloga goiana Nathália Machado ensina e mostra na prática a sua Agrofloresta que nasceu há 6 meses no Jardim América

24/05/2020

24/05/2020

Hydroxychloroquine or chloroquine, when used alone or with a macrolide, do not have their benefit confirmed on in-hospital outcomes for COVID-19. These drug regimens were instead associated with increased frequency of ventricular arrhythmias and death rate in-hospital. Researches advise therefore to not use these drugs outside of clinical trials and call for urgent confirmation from randomised clinical trials.

We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for trea...

20/05/2020

It wouldn’t be a publication of “Nature” if the title weren’t that striking. But while from one side we may agree that there is the protectionism from China to preserve their milenar practices without the so called “clear evidences”, i.e. scientific based and under the state-of-the-art clinical protocols, on the other side there is the big lobby of the pharmaceutical companies pulling down anything else that goes against their business. Talking about safety and drug marketing can be much complex than we think. Are you sure that the pharmaceutical companies are searching for a drug to hit COVID-19 because they are interested in the safety of the population...and not anything else behind? But luckily we have nowadays well stablished guidelines in most of the communities to evaluate, control and monitorate the safety of treatments that are coming into the market.

Scientists say rigorous trial data are needed to show that remedies are safe and effective.

18/05/2020

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HERB-DRUG INTERACTIONS .

Concomitant oral administration of some herbal products and prescription drugs may affect human drug metabolism and alter drug bioavailability. This can increase the risk of serious (clinical) adverse reactions and toxicity, or decrease in efficacy.

This is because several phytoconstituents are inhibitors or inducers of cytochrome. Most of the herb-drug interactions occur due to either induction or inhibition of these enzymes.

Cytochrome P450 (CYP450) is a family of enzymes found mainly in the liver, but also in the small intestine, placenta, lungs and kidneys, which are responsible for the metabolism of some important endogenous substances and a variety of xenobiotics including therapeutic drugs.
Any inhibitory effect of herbal extracts on CYP may result in enhanced plasma and tissue concentrations leading to toxicity, while any inductive effect may cause reduced drug concentrations leading to decreased drug efficacy and treatment failure.

Considering the chances of herb-drug interaction, it is highly recommended to inform your health care practitioners about the e use of herbal medicines and natural supplements if you are taken prescription drugs, specially if they have a narrow therapeutic index ————————————————————————
REFERENCES:
1. Wang, K et al. Inhibition of CYP2C9 by natural: insight into the potencial risk of herb-drug interactions products. Drug Metabolism Reviews, 2020.
2. Mukherjee PK. Evidence-Based Validation of Herbal Medicine. Elsevier, 2015, 1774 p.
3. Elizabeth W. et al. Stockley's Herbal Medicines Interactions: A Guide to the Interactions of Herbal Medicines. Pharmaceutical Press, 2nd Ed, 2013, 528p.
4. Sprouse AA, van Breemen RB. Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements. Drug Metab Dispos. 2016;44,162‐171.
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̈uter . @ Berlin, Germany

18/05/2020

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I wish all mothers a wonderful day!
Thank you for being there, for being inside, anywhere you are .
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̈uter

18/05/2020

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Does NATURAL mean HARMLESS ? NOT REALLY !
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🌱In previous posts we highlighted that Herbal Medicines and Phytopharmaceuticals are complex mixtures and that these substances are also chemicals, or better saying “biochemicals”, as funny described in the charge above, because they are natural .
🌱I have also explained previously that due to the lower concentration of active substances and often synergic effect from different substances present these natural medicines, they usually have very few side effects .
🌱 Nevertheless, Herbal Medicines should be taken with care. Here are a few reasons why :

1. There are biochemicals present in certain plants that are considerably toxic when taken orally, although they might not be toxic when used externally. There are others that can be toxic if used for long time .
2. Some biochemicals may interact in deferent manners with other medicines and other Herbal medicines when taken together (poli pharmacology). For instance, they may reduce or increase the metabolism of other drugs, thus affecting patient treatment.
3. There are a few biochemicals witch teratogenic and they must not be used during pregnancy .
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In the next posts we will talk more about toxicity and pharmacological interactions of Herbal Medicines.
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FOLLOW .verde FOR MORE!
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̈uter .

18/05/2020

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Additional information to our last post!

I received a few questions if compounds originated from plants are used in Phytotherapy. The answer is NO .
🌱 An isolated compound of plant origin is neither an herbal medicine nor a phytopharmaceutical (🇩🇪 Phytopharmaka, 🇧🇷medicamento fitoterápico). It is also important to clarify that in Phytopharmaceutical formulations it is not allowed the addition of any pure substance, neither a phytochemical🌿💊 (substance of plant origin) nor a synthetic drug 🧪💊.
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̈uter .