
18/03/2024
Polycystic o***y syndrome (PCOS) is a major cause of infertility around the world. The disorder is characterised by elevated secretion of androgens resulting in of ovarian enlargement with accumulation of fluid filled cysts, irregular menstrual cycles and hirsutism. A single-arm study assessed the efficacy of proprietary standardised fenugreek (Trigonella foenum-graecum) seed extract (1,000 mg/day) in 107 female volunteers (aged 18 to 45 years) over a period of 12 consecutive weeks.
The herbal treatment induced a greater than 40% reduction of mean cyst sizes in both ovaries, with a corresponding reduction in ovarian volumes. The LH:FSH ratio was also significantly improved, with a corresponding reduction in total testosterone and prolactin levels. As a result of this improvement in endocrine function, menstrual cycles became more regular in the trial participants. PCOS is also characterised by insulin resistance, and the fenugreek treatment also reduced its severity, together with significantly correcting dyslipidaemia and improving liver function.
For more information see https://pubmed.ncbi.nlm.nih.gov/36441141/