10/12/2022
كل ما تريد معرفته عن جدري القرده monkey box
أولا الفيروس ده قديم جدا مش جديد ولا حاجه
Monkeypox is caused by the monkeypox virus The virus was first isolated in 1958 following an investigation into a pox-like disease occurring in monkeys.
It was first detected in humans in 1970
______________________________&________________
بيتنقل من الحيوانات للإنسان إزاي ؟
Animal-to-human transmission can occur from the bite or scratch of an infected animal; during activities such as hunting, trapping, skinning, cooking, or ingestion of infected animals; or from contact with infected bodily fluids
__________________________&____________________
بيتنقل من إنسان إلي إنسان ازاي ؟
Human-to-human transmission occurs through direct contact with infectious skin or mucocutaneous lesions and respiratory droplets (and possibly short-range aerosols requiring prolonged close contact).
Fomite transmission can also occur (e.g., from contaminated clothing or linens).
Perinatal transmission has been reported
________________________&______________________'
The incubation period is 6 to 13 days (range 5 to 21 days).
A person is not contagious during this period.
________________________&______________________
أعراض المرض
👌Constitutional symptoms (FAHM ) fever, headache, Malaise, Anorexia
👌Lymphadenopathy
👌Anorectal pain
👌Characteristic skin rash
بييدأ في صورة macule وبعدين تبقي papule ثم تقلب umbilicated pustule وبعدين تعمل scale وتقشر
فهو يشبه حاجات كتير
علشان كده بيقسموا الحالات الي
👌1- حالات مشتبه فيها suspected case
ده اي عيان عنده طفح جلدي ومش عارفين سببه
+ عرض أو اتنين من الآتي
👉Fever
👉Lymphadenopathy
👉Fatigue
👉Headache
👉Bone or muscle pain
👌2_ حالات محتمله
دي نفس الحاله المشتبهه الي فوق
+ واحد أو اتنين من الآتي
👉History of travel to an area where there's is an outbreak
👉History of contact with confirmed case
👉History of multiple sexual relationship on the past 21 days
👌3_ حاله مؤكده confirmed case
عليها الأعراض وتم تأكيد الاصابه ب ال PCR
_______________________&_______________________
Investigations
👈تأكيد التشخيص ب PCR
👉CBC changes in monkey pox
may show leukocytosis, lymphocytosis, thrombocytopenia
👉Tests for STDs في الجماعه إياهم
👉Blood culture if secondery bacterial infection is suspected
________________________&______________________
Prevention
Vaccine for Monkeypox (JYNNEOS vaccine)
Given for high risk populations e.g family or partner of positive patients or in countries of monkeypox outbreak (Under Emergency use Authorization)
Regimen: Standard SC / Alternate ID
*Standard regimen: for people 18yrs
2 doses with 28days apart injected Intradermal (0.1 ml)
peak immunity after 14 days from 2nd dose but duration of immunity still unknown
_______________________&_______________________
Treatment
👉Mild and uncomplicated cases
Isolation
Symptomatic treatment
Monitoring
👉Sever or complicated cases
Hospital admission
Monitoring and supportive measures
Antiviral (Tecovirimat)
Antibiotics if secondary bacterial infection occurs
_________________________&_____________________
امتي يفك العزل
👈لو ال PCR أصبحnegative
👈أو no New skin lesion for more than 48 h
👈أو الskin lesion حصها scrub ووقعت
ومفيش mucous membrane lesions
_______________________&_______________________
Prognosis
Most cases are usually mild and self-limiting, and most patients will recover within 2 to 4 weeks without treatment.
More than 90% of survivors have no complications
Severe or complicated disease and death occurs more commonly in younger children and immunocompromised people.
________________________&______________________
Complications
👉Sepsis
👉Acute kidney injury
👉Skin or soft tissue infection
👉Pneumonia
👉Myocarditis
👉Anorectal pain
👉Urine retention
👉Neurological complications
