03/09/2025
Scientists have discovered that a gum-disease bacteria called Porphyromonas gingivalis may play a hidden role in Alzheimer’s disease.
This microscopic organism, often found in bleeding or inflamed gums, doesn’t just stay in the mouth. Research shows it can enter the bloodstream, travel to the brain, and release toxic enzymes known as “gingipains.” These enzymes can damage brain cells, spark chronic inflammation, and even accelerate the buildup of amyloid plaques—sticky protein clusters that are strongly linked to memory loss and cognitive decline.
In animal studies, infection with P. gingivalis led to brain changes strikingly similar to those seen in Alzheimer’s patients. Even more concerning, human studies have detected traces of these bacterial toxins in the brains of people with Alzheimer’s.
While brushing and flossing may seem like small daily habits, the latest evidence suggests they could also be one of the simplest ways to reduce risks that reach far beyond the mouth—possibly protecting the brain itself.
📄 Research paper: Seyedmoalemi, S., et al. (2025). Association between periodontitis and Alzheimer’s disease: A systematic review.
PMCID: PMC11889340
