Neuronet

26/09/2022

Have a read of the latest Innovative Health Initiative (IHI) funded publication investigating the association between different AD polygenic risk scores (PRS) and amyloid accumulation in the Flemish Prevent AD Cohort KU Leuven (F-PACK).

Congratulations to the authors Emma Luckett, Yasmina A., Mariska Reinartz, Kasia Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen & Rik Vandenberghe!

Background Early detection of individuals at risk for Alzheimer’s disease (AD) is highly important. Amyloid accumulation is an early pathological AD event, but the genetic association with known AD risk variants beyond the APOE4 effect is largely unknown. We investigated the association between di...

15/09/2022

Have a read of the latest Innovative Health Initiative (IHI) funded study, investigating the performance of participants with and without diabetes on a task of allocentric spatial processing.

Congratulations to the authors Sarah Gregory, Kaj Blennow, Natalie Homer, Craig Ritchie, Graciela Muniz Terrera and the whole consortium!

Type 2 diabetes is a robust predictor of cognitive impairment. Impairment in allocentric processing may help identify those at increased risk for Alzheimer’s disease dementia. The objective of this s...

31/08/2022

📢 Mobilise-D Webinar: Multiple Sclerosis 📢

Just one week until our first webinar this autumn!

📅 Wednesday, September 7
⌚️ 16:00 CET
🆓 Free and open to the public

Haven't signed up yet? Register now👇

🔗https://www.mobilise-d.eu/webinar-series-mobilise-d-presents-its-four-patient-cohorts

31/08/2022

Read the latest Innovative Health Initiative (IHI) funded publication that found a significant interaction between APOE status, s*x, and CSF Aβ on CSF p-tau levels

Congratulations Tyler Saunders, Natalie Jenkins, Kaj Blennow, Craig Ritchie and Graciela Muniz Terrera!

An interaction between s*x and cerebrospinal fluid Aβ may mediate the relationship between APOE status and CSF p-tau. These data suggest tau accumulation may be independent of Aβ in females, but not males.

29/08/2022

The goal of the Innovative Health Initiative (IHI) funded PRISM 2 project is to build on the achievements of the original PRISM project. Specifically, it aims to validate PRISM’s findings on social dysfunction in schizophrenia and Alzheimer’s disease, and investigate whether they also apply to major depressive disorder.

https://vimeo.com/687937223

29/08/2022

What is it like to work as a communication expert on public-private partnerships in life sciences?

Read our communication blog with Cindy Birck from Alzheimer Europe who is involved in Innovative Health Initiative (IHI) flagship projects on neurodegeneration

Neuronet is a Coordination and Support Action for the Innovative Medicines Initiative’s research projects on

25/08/2022

Have a read of the latest Innovative Health Initiative (IHI) funded publication outlining the current knowledge around the vital role of the apoptosis-inducing factor by primarily focusing on currently reported human diseases that have been linked to AIFM1 deficiency.

Congratulations to the authors Lena Wischhof, Enzo Scifo, Dan Ehninger, Daniele Bano and the whole consortium!

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00413-3/fulltext

25/08/2022

📢Four NEW Mobilise-D webinars this autumn📢

We will show you the project cohorts and the status of the clinical trials. In the first webinar we present our cohort.

Save the dates(s) and register now⤵️

📅 September 7th
⌚️16:00 CET

🔗https://www.mobilise-d.eu/webinar-series-mobilise-d-presents-its-four-patient-cohorts

24/08/2022

The Biomedical Knowledge Miner (BiK>Mi) has been developed as part of the Innovative Health Initiative (IHI) funded project at Fraunhofer SCAI.
This platform provides tools to access & validate knowledge pertaining to 's disease.

Find out more:

A tool to access & validate knowledge pertaining to Alzheimer's disease. Check it out now.

23/08/2022

What is it like to work as a communication expert on public-private partnerships in life sciences?

Read our communication blog with Yoanna de Geus from Lygature who is involved in Innovative Health Initiative (IHI) flagship projects on neurodegeneration 🧠 RADAR-CNS & RADAR-AD ⤵️

Neuronet is a Coordination and Support Action for the Innovative Medicines Initiative’s research projects on

19/08/2022

The Alzheimer’s Association International Conference is the largest and most influential international meeting dedicated to advancing dementia science. Each year, AAIC convenes the world’s leading basic science and clinical researchers, next-generation investigators, clinicians and the care research community to share research discoveries that’ll lead to methods of prevention and treatment and improvements in the diagnosis of Alzheimer’s disease. This year, the conference took place from 31st July to 4th August as a hybrid event (online and in San Diego, US) and attracted over 10,000 attendees.

We were pleased that several EPAD researchers presented their respective work at the Alzheimer’s Association International Conference

– Sarah Gregory (UEDIN): “Does adherence to the Mediterranean diet have differential effects on brain health for those living within and outside of the Mediterranean region?”

– Luigi Lorenzini (VUmc): “Concerted alterations of functional connectivity and WM integrity in relationship to early amyloid deposition”

– Luigi Lorenzini (VUmc): “Functional eigenvector centrality dynamics are related to amyloid deposition in preclinical Alzheimer’s Disease.”

– Gonzalo Sánchez Benavides (BBRC) “Re-examining the impact of adjusting for education and s*x the RBANS delayed memory score: Implications on the cut-offs used to detect cognitive impairment in prodromal Alzheimer’s disease. Data from the EPAD-LCS study.”

– Irene Cumplido Mayoral (BBRC) “Biological Brain Age Prediction Using Machine Learning on Structural Neuroimaging Data: Multi-Cohort Validation Against Biomarkers of Alzheimer’s Disease and Neurodegeneration.

https://www.imi-neuronet.org/epad-presented-at-aaic2022/

16/08/2022

Our Innovative Health Initiative (IHI) funded IMI2_Neuronet Decision Tool provides a clickable overview of the processes and procedures for Health Technology Assessment & regulatory interactions at different stages of the development pipeline

https://kb.imi-neuronet.org/admin/decision_tool

10/08/2022

Mobility impairment is a strong modifiable predictor for incident disability in older adults (Braun et al. 2022).
➡️Assessments of mobility capacity may help identify older people at risk of incident disability
➡️Mobility assessment should be routinely established in regular health examinations.

Read the full systematic review here⤵️
https://www.sciencedirect.com/science/article/pii/S1568163722001465?dgcid=author

04/08/2022

Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes (Polhemus et al. 2021)Read more here:https...

01/08/2022

Mobility is often said to be a sixth vital sign, just as important as other vital signs such as blood pressure and heart rate, and the key to independence in...

28/07/2022

The latest Innovative Health Initiative (IHI) funded publication demonstrates the importance of using well-optimised NMeds targeted with novel ligands to advance delivery & pharmaceutical effects against diseased cells while minimising the risk for nearby healthy cells.

Congratulations to the authors Jason Duskey, Arianna Rinaldi, Ilaria Ottonelli, Riccardo Caraffi, Chiara Alessia De Benedictis, PhD, Ann-Katrin Sauer, Giovanni Tosi, Maria Angela Vandelli, barbara ruozi, Andreas Grabrucker and the whole consortium!

Glioblastoma Multiforme (GBM) is a devastating disease with a low survival rate and few efficacious treatment options. The fast growth, late diagnostics, and off-target toxicity of currently used drugs represent major barriers that need to be overcome to provide a viable cure. Nanomedicines (NMeds)....

27/07/2022

Prof. Lynn Rochester and Dr. Ronenn Roubenoff explain how mobility is a vital sign and the benefits of being able to measure people's mobility in a reliable ...

19/07/2022

Mazzà et al. (2021). Technical validation of real-world monitoring of gait: a multicentric observational study Full text: https://bmjopen.bmj.com/content/11/...