Neurología y Neurofisiología - Dr. Jesús Llabrés

29/03/2026

La importancia de la salud de la boca

American researchers linked oral bacteria from your mouth to Alzheimer's plaques in brains

Every time you skip flossing, you might be doing something far more consequential than risking a cavity. Researchers at NYU College of Dentistry have published the strongest evidence yet that Porphyromonas gingivalis — the primary bacterium responsible for chronic gum disease — routinely invades the bloodstream through inflamed gum tissue and travels to the brain, where it produces toxic enzymes called gingipains that directly drive the formation of amyloid beta and tau — the two hallmark proteins of Alzheimer's disease. 🦠

The connection had been suspected since 2019 when gingipains were found in the brain tissue of Alzheimer's patients. The NYU team's 2025 research went further, using longitudinal data from 5,400 adults tracked for 22 years. They found that individuals with severe chronic periodontal disease had a 3.7-fold increased risk of developing Alzheimer's disease — independent of age, genetics, education, or any other known risk factor. The risk increased with disease duration and severity, suggesting a cumulative dose-response relationship.

Mechanistically, gingipains produced by P. gingivalis appear to cleave ApoE protein in the brain, promoting amyloid aggregation and simultaneously degrading tau-clearing enzymes. 🔬 When the NYU team administered a specific gingipain inhibitor drug to mice infected with P. gingivalis, brain amyloid deposition was reduced by 96% compared to untreated infected controls.

A gingipain inhibitor — COR388 — is currently in phase 2/3 clinical trials for mild-to-moderate Alzheimer's disease. This research elevates gum disease from a dental concern to a neurological emergency — and makes regular dental care the cheapest Alzheimer's prevention strategy in existence.

Source: NYU College of Dentistry, Science Advances, 2025

09/02/2026

El café en cantidad moderada y regular ofrece cierta protección contra la enfermedad de Alzheimer.

In a prospective cohort study involving more than 130 000 US adults followed for up to 43 years, higher intake of caffeinated coffee and tea was associated with lower risk of developing and modestly better cognitive performance, as measured by both subjective and objective tests.

The inverse association was most pronounced at moderate intake, approximately 2 to 3 cups per day of caffeinated coffee or 1 to 2 cups per day of tea, while decaffeinated coffee intake showed no significant relationship to dementia risk or cognitive outcomes.

https://bit.ly/4qv2MMZ

21/01/2026

Subir escaleras es más saludable que caminar

A prospective study shows climbing more than five flights of stairs daily is associated with a lower risk of atherosclerotic cardiovascular disease.

04/10/2025

La composición óptima es el orotato de litio, 10-25 mg/dia

03/10/2025

A groundbreaking new study published in Nature has revealed that a simple, low-cost lithium supplement could potentially reverse Alzheimer’s symptoms. Researchers found that naturally low lithium levels in the brain were consistently linked to the hallmarks of Alzheimer’s disease, including amyloid plaques, tau tangles, and severe memory decline.
Using mouse models, scientists discovered that lithium depletion worsened these brain changes, creating a harmful cycle where less lithium leads to more plaques, which then further reduce lithium levels. When lithium-deficient mice were treated with very low doses of lithium orotate, a form that avoids being trapped by plaques, brain damage reversed and memory function was restored. This effect was not seen with the more commonly prescribed lithium carbonate, possibly explaining the inconsistent results of earlier trials.
If these results translate to humans, lithium orotate could become a game-changing therapy, addressing multiple disease pathways at once without the toxicity seen in higher-dose treatments. Researchers also noted that healthy individuals with naturally higher brain lithium levels performed better on memory tests.
With dementia affecting over 55 million people worldwide, this inexpensive and safe approach could revolutionize Alzheimer’s treatment, offering hope for restoring memory rather than just slowing decline. Public funding may be key to bringing this breakthrough to human trials.

13/09/2025

Desequilibrio entre el parasimpático y el (elevado) tono simpático en una persona con fatiga crónica, irritabilidad y bajo rendimiento cognitivo a pesar de sueño de calidad aceptable pero moderadamente sedentario y síndrome metabólico.

13/09/2025

Variabilidad del ritmo cardiaco

30/08/2025

La sincronización audio visual con diferentes frecuencias proporciona una relajación psicofísica sin ansioliticos.

20/08/2025

Comentario

¿Dolor de cabeza después de beber vino tinto? Esta Podría Ser La Razón

El alcohol es metabolizado por la enzima alcohol deshidrogenasa en el intestino y luego en el hígado. Eso lo convierte en acetaldehído, un metabolito tóxico. En la mayoría de nosotros, la aldehído deshidrogenasa (ALDH) metaboliza rápidamente el acetaldehído al acetato inerte, que se puede excretar de forma segura.
Sin embargo, algunas poblaciones, particularmente aquellas con ascendencia asiática oriental, tienen una mutación en el gen ALDH que puede conducir a la acumulación de acetaldehído tóxico con el consumo de alcohol, lo que lleva a cefalea. enrojecimiento facial y náuseas.

12/07/2025

11/07/2025

El abuso de los móviles produce cambios similares en nuestro cerebro a los que producen las adicciones.

💡 Software a medida, a un 𝗽𝗿𝗲𝗰𝗶𝗼 𝗺𝘂𝘆 𝗷𝘂𝘀𝘁𝗼

10/07/2025

Hay funciones que el cerebro SOLO realiza durante el sueño. Además, la falta de sueño acentúa procesos que acaban autolesionando el cerebro.

Scientists found that the brain literally starts eating itself when it doesn't get enough sleep.
New research reveals a troubling link between chronic sleep deprivation and long-term brain damage.
Scientists studying sleep-deprived mice discovered that prolonged lack of sleep causes the brain’s immune cells—astrocytes and microglia—to go into overdrive.
Astrocytes, which normally prune away unnecessary synapses, began breaking down more brain connections and debris, while microglia, responsible for clearing damaged cells, showed heightened activity. Although these processes may initially serve a protective role, overactivation of these cells has been linked to neurodegenerative conditions like Alzheimer’s disease.
These findings shed light on why chronic sleep loss is increasingly associated with heightened risk of dementia and cognitive decline. Sleep is a vital state for brain maintenance—it clears toxic waste, consolidates memory, and reinforces crucial neural connections.
Without it, the brain's restorative systems falter, impairing attention, memory, and emotional stability. As Alzheimer’s deaths have surged 50% since 1999, understanding sleep’s role in brain health has never been more critical. This research underscores the urgent need to prioritize sleep not just for daily function, but as a safeguard for long-term neurological health.

This is a powerful reminder: your brain needs sleep to survive and thrive. 🛌🧠

🔗 Full article: https://www.sciencealert.com/your-brain-starts-eating-itself-due-to-lack-of-sleep