25/07/2025
Thanks to my colleagues, we have finally answered a recurrent question from clinicians taking care of severest neonatal RDS. When should we go for an ultrasound-guided surfactant re-treatment? It was very complex to answer as we needed many patients given the low prevalence of retreatment with optimal resoiratory care. Thus we needed a multi center design with centers having exactly the same respiratory care policy and the right timing for a second poractant-alpha dose (see our paper in Intensive Care Medicine 2011, back in another era!)… but we did it! Lung ultrasound aeration score indicates the need for retreatment with the same accuracy and same threshold of the first dose but only if performed about 12h from the first dose! 705 extremely preterm patients, in three academic NICUs in 🇪🇺(🇫🇷🇮🇹🇪🇸) published on The Lancet EBiomedicine, open access available at:
https://www.sciencedirect.com/science/article/pii/S2352396425003093?ref=pdf_download&fr=RR-2&rr=964ef59a5e68bb36