Intensive Care Medicine

Intensive Care Medicine The official page for ICM, Intensive Care Medicine.

ICM is an international peer-reviewed medical journal intended for all those who are involved in intensive care medicine. ''Intensive Care Medicine'' is the publication platform for the communication and exchange of current work and ideas in intensive care medicine. The journal publishes original research papers, reviews, as well as discussions on technology, methods, new apparatus and modifications of standard techniques and correspondence concerning matters of topical interest or relating to published material. Official journal of The European Society of Intensive Care Medicine and The European Society of Paediatric and Neonatal Intensive Care.
12 issues per year.

https://zurl.co/KhmxZ PEEP can raise PaO2 while reducing global oxygen delivery when cardiac output falls. In ARDS it en...
13/01/2026

https://zurl.co/KhmxZ PEEP can raise PaO2 while reducing global oxygen delivery when cardiac output falls. In ARDS it enlarges the baby lung by recruiting dependent regions but can also overdistend already aerated units and stabilise airways above the airway opening pressure. Its haemodynamic effects alter venous return, right ventricular afterload and left ventricular afterload, influencing end-organ perfusion.

https://zurl.co/46Rgz -Quizz Streptobacillus moniliformis, a fastidious Gram-negative rod linked to rodents, caused s...
13/01/2026

https://zurl.co/46Rgz -Quizz Streptobacillus moniliformis, a fastidious Gram-negative rod linked to rodents, caused septic shock with cervical and lumbar spondylodiscitis and compressive epiduritis. Growth occurred in anaerobic blood culture bottles; identification used MALDI-TOF and 16S rRNA PCR from the vertebral site. Aortic valve thickening suggested endocarditis. Severe presentation and precarious living conditions guided prompt targeted therapy.

-Quizz A 59-year-old homeless man presented in septic shock with extensive spondylodiscitis at C3–C4 and L5–S1. He ha...
12/01/2026

-Quizz A 59-year-old homeless man presented in septic shock with extensive spondylodiscitis at C3–C4 and L5–S1. He had no significant medical history and no prior medication use. Two anaerobic blood cultures became positive after 70 hours. MRI and microscopy findings are shown, and transoesophageal echocardiography revealed aortic valve thickening. What's your diagnosis?

https://zurl.co/uhS62 Multiple physiological variables obtained during a decremental PEEP trial were compared. Thirty in...
12/01/2026

https://zurl.co/uhS62 Multiple physiological variables obtained during a decremental PEEP trial were compared. Thirty intubated ARDS patients on pressure support ventilation completed a decremental PEEP trial from 18 to 4 cmH2O with airway and oesophageal pressure and electrical impedance tomography monitoring. Overdistension–collapse and end-expiratory transpulmonary pressure varied most with PEEP and selected different personalised levels. Lung and diaphragm protection markers were similar, with subgroup differences by PaO2/FiO2 and ventilatory ratio.

https://zurl.co/rHiZa Recommendations endorsed by eight UK professional societies were refined through a modified Delphi...
11/01/2026

https://zurl.co/rHiZa Recommendations endorsed by eight UK professional societies were refined through a modified Delphi process. Emergency response is organised into a circuit team prioritising restoration of ECMO function and a patient team applying ECMO-adapted resuscitation protocols under a designated leader. UK delivery is centralised across 14 centres for about 69 million people, and uptake depends on training, local adaptation, and evaluation of outcomes and team performance.

https://zurl.co/pt4qd Guidance advises avoiding polyacrylonitrile filters in continuous kidney replacement therapy duri...
11/01/2026

https://zurl.co/pt4qd Guidance advises avoiding polyacrylonitrile filters in continuous kidney replacement therapy during caspofungin treatment. Two in vitro AN69ST circuits with crystalloid central compartments showed complete drug disappearance within 6 hours, without effluent detection, indicating adsorption. Retrospective analyses reported no underdosing and sometimes higher plasma levels during polyacrylonitrile CKRT, supporting further study.

https://zurl.co/ovzob Serial biomarker measurements in sepsis reveal three immune profiles that often change over 8-ho...
10/01/2026

https://zurl.co/ovzob Serial biomarker measurements in sepsis reveal three immune profiles that often change over 8-hour intervals, with around one third of subgroup peers reclassified at each time point. Persistent instability in class membership and limited intra-class cohesion raise concerns about temporal robustness and clinical applicability of biomarker-based endotyping strategies.

https://zurl.co/tyzHk Most clinicians monitored respiratory effort in invasively ventilated patients, based on 256 respo...
10/01/2026

https://zurl.co/tyzHk Most clinicians monitored respiratory effort in invasively ventilated patients, based on 256 respondents. P0.1 and Pocc were the most common quantitative tools, while oesophageal balloons were used selectively and diaphragm electrical activity was often unavailable. Excessive efforts typically led to increased ventilatory support and sedation, while insufficient efforts typically led to reduced sedation and ventilator adjustment.

https://zurl.co/Wwz0k Observational studies can provide rapid real-world insights but carry a higher risk of bias. Appra...
09/01/2026

https://zurl.co/Wwz0k Observational studies can provide rapid real-world insights but carry a higher risk of bias. Appraisal checks whether covariates precede exposure, confounders are adjusted for, mediators are analysed separately and colliders are avoided. Handling of missing data, overfitting, propensity score diagnostics, robustness and sensitivity analyses, multiplicity and model assumptions affects confidence and generalisability.

https://zurl.co/BLPjF Brain-dead donors were randomised 1:1 to 2.5 mg/kg cyclosporine or 5% glucose placebo 2–6 h before...
09/01/2026

https://zurl.co/BLPjF Brain-dead donors were randomised 1:1 to 2.5 mg/kg cyclosporine or 5% glucose placebo 2–6 h before kidney removal. Delayed graft function was defined as at least one hemodialysis within 7 days after transplantation. DGF occurred in 46/331 recipients (13.9%) with placebo and 53/312 (17.0%) with cyclosporine, with no significant between-group differences in early graft function or 1-year graft and recipient survival.

https://zurl.co/fBEgs Using data from 45,242 ICU stays with acute kidney injury and organ support in 34 French centres...
08/01/2026

https://zurl.co/fBEgs Using data from 45,242 ICU stays with acute kidney injury and organ support in 34 French centres between 2008 and 2019, the authors show a sustained fall in renal replacement therapy use, from 39.7% to 35.9% of stays. Annual crude rates dropped from 441 to 339 treatments per 1,000 stays, alongside a move away from intermittent dialysis towards continuous techniques.

https://zurl.co/8Y1VR Major bleeding is symptomatic bleeding in a critical area or organ, or a haemoglobin fall of at le...
08/01/2026

https://zurl.co/8Y1VR Major bleeding is symptomatic bleeding in a critical area or organ, or a haemoglobin fall of at least 2 g/dL, or transfusion of at least 2 units of whole blood or red cells. Major haemorrhage protocols coordinate rapid delivery of red cells, plasma and platelets to reduce dilutional coagulopathy. Massive transfusion is typically at least 10 red cell units within 24 hours.

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