30/07/2022
Sometimes we need to do our own research - well done Trauma geek and thank you!
What are mast cells?
Mast cells live in our connective tissue. They hold granules of histamine and other inflammatory mediators. Mast cells are part of our protective immune response and they are also involved in allergy, anaphylaxis, and systemic inflammation.
What are mast cell syndromes?
Mast cell syndromes are conditions that cause mast cells to degranulate and release large amounts of pro-inflammatory chemicals into the body, causing potentially life threatening allergy responses. These allergy responses can range from constant mild swelling (which can cause depression and suicidality) to severe anaphylaxis.
What is mast cell degranulation?
When a mast cell encounters an allergen, it releases inflammatory mediators including histamine. These chemicals induce swelling, coughing, sneezing, itchiness, & cramping of the gut to help the body expel pathogens. Mast cell degranulation is a normal part of the neuro-immune response but mast cells can become hypersensitive in some people.
What conditions are mast cells involved in?
Mast cell activation is the source of symptoms in many chronic illnesses. Mast cell degranulation is a part of MCAS, mastocytosis, ME/CFS, most post-viral illnesses, long covid, chronic Lyme, severe vaccine reactions, toxic mold exposure, fibromyalgia, IBS, migraine, endometriosis, PMDD, and more.
Mast cell issues are not rare - a fact the mainstream medical industry has barely begun to acknowledge. Medical gaslighting or other mistreatment of patients frequently occurs when patients present with the multi-system sporadic symptoms of mast cell degranulation. Symptoms of mast cell conditions are often incorrectly attributed to psychological conditions.
Root causes of mast cell hyper-sensitivity include genetic predisposition, unsupported neurodivergence, stress, trauma, environmental toxins, and untreated conditions like EDS or autoimmune disease.
Here are some day to day supports for mast cell syndromes. (Please note, this is not how to treat severe flares - for severe mast cell flares, especially ones involving anaphylaxis, you may need emergency medical assistance)
1. Hydration with electrolytes not just plain water
2. Eating more protein / Amino acids than a typical diet
3. Vitamin D, Vitamin C, calcium
4. Magnesium salt baths
5. Natural mast cell stabilizers
6.. Over the counter allergy medicines - antihistamines and nasal sprays
7. A home environment that is soothing for the nervous system
8. Gentle movement like spinal waves or walking to move our glymphatic system
9. Avoiding known triggers whenever possible
10. Music & Co-regulation
I'm writing about mast cells because mast cell issues are more common in neurodivergent people and because lack of support for or even recognition of these conditions is a source of ongoing trauma in our community.
I have had MCAS since I was a teenager. I also had long Covid from Feb 2020 to May 2021, which felt like a year-long MCAS flare. I have more or less been on my own in recognizing my illness (a doctor eventually confirmed it), managing my chronic symptoms, and treating my severe flares. I know more about mast cell stuff than the majority of doctors I visit because I turned to self-education for survival.
I want to particularly offer consultations for mast cell education. I teach on a wide range of topics under the umbrella of trauma and neurodiversity, but this one is closest to my heart right now. Understanding mast cells has helped me avoid some flares, reduced my suffering during flares, and also helps me determine what level of medical care I need for flares. I would love to offer a group training on this in the future, but right now I am being careful to avoid burnout so I am limited to 1:1 educational talks. [To schedule, go to calendly.com/TraumaGeek]
If you'd like to do some of your own research on mast cells, here are some articles to get you started . . .
👉 https://www.sciencedirect.com/topics/medicine-and-dentistry/mast-cell-degranulation
👉 https://cvm.msu.edu/news/2018/dont-overreact-research-pinpoints-mast-cell-receptor-in-immune-response-disease-signs
👉 https://www.healthrising.org/blog/2021/11/13/mast-cell-activation-ibs-fibromyaglia-chronic-fatigue-syndrome/
👉 https://solvecfs.org/research-and-registry/ramsay-research-grants/meet-the-researchers/theoharis-theoharides/
👉 https://me-pedia.org/wiki/RCCX_Genetic_Module_Theory
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