AIMS Trial

Can giving antibiotics to women having surgery for miscarriage management reduce infection in develo
(1)

Infection following miscarriage surgery is a problem affecting over 33 million pregnancies each year. A majority of women will have their miscarriage managed with surgery to empty the womb. Infection can occur following this surgery and this is a particular problem in low income countries. In some low income countries the rates of infection following miscarriage surgery are as high as 30%. These infections can result in death, serious illness or long-term health problems. Currently international and national medical guidelines do not recommend antibiotics to be given routinely in miscarriage surgery, because there is no evidence that tells us that this is effective. We propose that if antibiotics are given just before the procedure of miscarriage surgery this may reduce the chance of infection occurring. We will test this in the form of a large clinical trial conducted in four low income countries. Women having miscarriage surgery who are not showing any signs of infection will be invited to participate. If consent is given women will be offered either a single dose of prophylactic antibiotics (400mg doxycycline and 400mg metronidazole) or an identical looking dummy pill (placebo), to be taken by mouth before the surgery. Both the woman and health worker will not know which type of tablets they have been given. The use of dummy pills helps identify the true difference the antibiotics make. We will carefully follow participants for 2 weeks after surgery to see if there is any difference in the rate of women developing pelvic infection. If any women show signs of infection they will be given full treatment as soon as it is detected. We will also see if using antibiotics before surgery is cost effective

04/11/2019

YES the results are out!!!! Read all about it!!

We cannot thank the entire team enough for their hard work every step of the way.

https://www.nejm.org/doi/full/10.1056/NEJMoa1808817

Original Article from The New England Journal of Medicine — A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery

11/05/2017

End of trial celebrations from team Pakistan 😍 what a fab team!

05/05/2017

Happy International Day of the Midwives to All Fabulous Midwives out there!

20/04/2017

So Team - We have done it
3400 patients - you are amazing - thank you from the bottom of my heart :)

19/04/2017

Just two more patients to go team 😊😊👌

19/04/2017

A fantastic 4 patients left to randomise 😍 our team is simply amazing

14/04/2017

Just 11 more participants to go team - you are amazing!

12/04/2017

A nail-biting 18 patients to go - amazing work teams!!!

11/04/2017

WOW ... 24 patients left - great work today teams :)

11/04/2017

Just 31 more patients thanks to the Amazing AIMS Team

10/04/2017

32 more patients to go :) :) :)

10/04/2017

We need 35 more patients please team! We haven't finished yet... please please please can we aim for at least 1 a day from each site - :)

07/04/2017

Thank you Prof Jane Daniels for all of the support you have given the AIMS team - we are sad to see you go... 😢

05/04/2017

We are getting closer to the big total - just 41 participants left :)

03/04/2017

Just 46 more participants :) grand work teams

31/03/2017

Just 50 more patients - I'm more excited than this party giraffe

29/03/2017

Just a small message for our teams - yeah, you're the best :) just 56 more now :)

29/03/2017

Just 60 participants left to randomise - wow :)

28/03/2017

Just 63 participants left to randomise thank to our wonderful team 👏👏👏

27/03/2017

Just 69 participants left to randomise - how exciting 😬😬😬 great work as always teams 👍👍

22/03/2017

now.... just 99 participants left to recruit :)

22/03/2017

AMAZING AIMS TEAM - we have only 101 patients left to recruit - you super stars!!!

08/03/2017

Happy international women's day

07/02/2017

Awesome day at Soroti hospital, Uganda 😊😊

06/02/2017

Well done team Soroti! Great work by all!

06/02/2017

What a team! Soroti you are amazing! Thanks SAFRI for all the support

06/02/2017

We love Soroti's image of an ideal nurse - we think all of the AIMS nurses are this and more

06/02/2017

Sister Helen and Dr Ekunuit driving forward research to improve outcomes for mothers

03/02/2017

Great to be back in Mbale, Uganda with Team SAfRI

10/01/2017

Amazingly warm welcome by AIMS TEAM PAKISTAN - our visit has been long overdue... Sorry happy to finally be in Karachi 😊😊😊

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Soroti Uganda

Good news. This is the Hospital director of Soroti in Uganda handing over the signed MoU to Mr James Ditai in Mbale (Team Uganda Coordinator). Also featured is the Senior Consultant Obstetrician and Gynaecologist, the head of department of OB/GY and the site