26/01/2026
๐ฐ NEWS: A blood test can predict how well patients with advanced breast cancer will respond to targeted therapies โ before treatment begins, according to new research.
A team from The Institute of Cancer Research, London, used a liquid biopsy to detect the presence of tiny amounts of cancer DNA in the blood โ at the start of treatment, and four weeks into the treatment. They compared the levels of this DNA with patientsโ outcomes โ including how long it took for a cancer to grow, and how well the cancer was responding to treatment.
The findings, published in the journal Clinical Cancer Research, involved analysing blood samples from patients enrolled in the plasmaMATCH trial for circulating tumour DNA (ctDNA) that is released into the bloodstream by cancer cells. The researchers, based at the Breast Cancer Now Toby Robins Research Centre at The Institute of Cancer Research, saw a strong association between low levels of ctDNA at the start of treatment, and treatment response. A similar association was seen after four weeks โ one treatment cycle.
The results show that it is possible to monitor how well treatment is working through a non-invasive blood test, meaning patients who are not responding well could be identified and moved to alternative treatments sooner.
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A blood test can predict how well patients with advanced breast cancer will respond to targeted therapies โ before treatment begins, according to new research.