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Liquid Biopsy

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Liquid biopsy is always with you in the battle with cancer.

20/09/2025

Gastrointestinal cancers are among the deadliest worldwide, largely because they’re often detected too late.

What if we could catch them earlier, with just a simple blood test? 🩸

That’s where AI-powered liquid biopsy comes in. By combining cutting-edge machine learning with multi-omics biomarkers like circulating tumor DNA, exosomal RNA, and tumor-educated platelets, researchers are unlocking new ways to:
✅ Detect cancer at its earliest stages
✅ Improve patient stratification
✅ Move closer to truly personalized medicine

Of course, challenges remain: ultra-low biomarker levels, data variability, and regulatory validation. But advances in federated learning and ethical AI frameworks are paving the way forward.
🚀 The future? A world where early detection is the norm, not the exception; giving patients a far better chance at survival.
👉 What do you think; are AI-powered blood tests the next frontier for oncology?

📚 AI-powered liquid biopsy for early detection of gastrointestinal cancers

Pic: Gemini

12/09/2025

AI + Liquid Biopsy = A New Era in Cancer Detection

Early detection of liver metastases in gastrointestinal cancers has always been a major challenge. But new research shows that combining Artificial Intelligence (AI) with liquid biopsy is changing the game.

🔬 Key results:
- AI-driven analysis of liquid biopsy data significantly improves the sensitivity and accuracy of detecting liver metastases.
- Non-invasive tests can now spot disease earlier than traditional imaging methods.
- This approach could help clinicians tailor treatments sooner, improving patient outcomes and survival rates.

💡 Why this matters:

By uniting the power of AI algorithms with the precision of circulating tumor DNA analysis, we’re moving closer to a future where cancer can be caught before symptoms appear and treated at the right time.

👉 Imagine the impact: fewer late-stage diagnoses, more personalized therapies, and lives saved through earlier intervention.
The intersection of AI and precision oncology isn’t just innovation, it’s a revolution in how we fight cancer.

✨ What are your thoughts? How soon do you see AI-enabled liquid biopsy becoming part of routine clinical care?

For more: Artificial Intelligence (AI) and Liquid Biopsy Transforming Early Detection of Liver Metastases in Gastrointestinal Cancers.

Pic: Perplexity

01/08/2025

Exciting breakthrough in brain cancer detection! A recent study published in Cancer Discovery (April 29, 2025) introduces a liquid biopsy technique using genome-wide cell-free DNA fragmentomes. This AI-powered method, developed by Johns Hopkins Medicine, achieved a 75% detection rate in 505 patients, offering a non-invasive way to diagnose brain cancer early. Kudos to the team led by Dimitrios Mathios and Victor E. Velculescu for pushing the boundaries of medical innovation!

To read more: Detection of brain cancer using genome-wide cell-free DNA fragmentomes

pic:ChatGPT

05/10/2023

October is widely recognized as Breast Cancer Awareness Month. Join us in the fight against breast cancer. Let’s raise awareness, enhance understanding, and work towards a future where breast cancer is detected early, treated effectively, and lives are saved. Together, we can make a difference.

01/10/2022

📚Fred Bunz, Principles of Cancer Genetics Third Edition Capture 9 Cancer Detection and Prognostication Page 378.

24/09/2022

📚 Atlas of Liquid Biopsy Circulating Tumor Cells and Other Rare Cells in Cancer Patients’ Blood. Chapter 1, page 2. Ludmilla Thomé Domingos Chinen

16/08/2022

The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas its absence predicts a low risk of recurrence.
📚 Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer

08/08/2022

ATAC-seq is a sensitive method to detect eccDNA present in a tumor at the pre-amplification stage and can be used to predict resistance to therapy.
📚 ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines
📚Pic; https://www.cancer.gov/about-nci/organization/ccg/blog/2018/atac-seq

17/07/2022

Pre-PCR Mutation-Enrichment Methods for Liquid Biopsy Applications

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