Cambridge Progressive MS Clinic

26/07/2025

Ocrelizumab IV administration has taken up to five hours but injections will make ‘significant difference’

22/07/2025

Delighted to have had this long and absolutely enjoyable chat with Barry Singer MD about stem cells, multimodal mechanisms of action, promises and expectations, and concrete possibilities — up to the most recent first-in-human clinical trials aiming to apply the most sophisticated principles of regenerative neuroimmunology to the development of therapeutically effective advanced treatments for patients with progressive multiple sclerosis. I hope you appreciate the effort.

International Progressive MS Alliance University of Cambridge Department of Clinical Neurosciences Cambridge RESTORE

Podcast Episode · MS Living Well: Key Info from Multiple Sclerosis Experts · 22/07/2025 · 46m

30/05/2025

28/04/2025

As we kick off MS Awareness Week (https://www.mssociety.org.uk/get-involved/ms-awareness-week), I’m thrilled to share some exciting news! 🎉 Our collaborative project with Angelo Luigi Vescovi has been awarded funding from the International Progressive MS Alliance. This support enables us to begin human trials investigating neural stem cell transplants as a treatment for progressive MS.
This significant progress opens the door to a future phase 2 trial, where we will further explore the neuroprotective and neurorestorative potential of neural stem cells. We are honoured to support the Alliance's mission to discover innovative solutions for progressive MS and to push the boundaries of cell therapy in neurological disorders.

A heartfelt thanks to our incredible team: Olga Ciccarelli, Maria Pia Sormani, Frederik Barkhof, Luca Peruzzotti-Jametti, Maura Malpetti, James Rowe, Dominic Shadbolt, and Angelo D'Alessandro.



https://www.progressivemsalliance.org/2025/04/28/medicine-trial-development-awards/

Development projects in Canada and the United Kingdom receive €100,000 each to begin planning for future clinical trials

22/04/2025

Delighted to have contributed to the upcoming Webcast 'Putting People with MS at the Center of Research' | People affected by MS have been at the heart of the International Progressive MS Alliance since its beginning. With

Register Now: https://msintfederation.org/webcast_april
Wednesday, 30 April 2025 at 11:00 am EDT, 4:00 pm BST, 5:00 pm CEST

People affected by MS have been at the heart of the International Progressive MS Alliance since its beginning. In fact, a critical element to the Alliance’s strategy is to amplify the voices and roles of people affected by MS.

21/04/2025

A little contribution for a better understanding of the promise of advanced stem technologies for innovative cures and MS research

Scientists use in vitro models to investigate MS. They can simulate simplified versions of cell interactions in the central nervous system.

05/04/2024

Excited to share my 20-year journey with Advanced Cell Therapies (ACTs) for hashtag . My enthusiasm stems from the success of phase I human trials, marking significant progress in the field. As we move forward, I envision continued advancements and breakthroughs in MS hashtag | University of Cambridge

Welcome to Living Well with MS, where we are pleased to welcome Dr Stefano Pluchino as our guest! Dr Pluchino is a Professor of Regenerative Neuroimmunology at Cambridge University and has been researching stem cell therapy for progressive MS. In this episode, Dr Pluchino speaks to Geoff about....

14/03/2024

This is nice | our own Dr Peruzzotti-Jametti, Consultant at Addenbrookes CUH, and his team has identified a new mechanisms by which microglia, the brain’s resident immune cells are in overdrive in progressive MS.

The brain’s resident immune cells are in overdrive in MS. New research has identified one potential reason why. And, how the cells could be controlled.

14/03/2024

Nice read about some MS research at Cambridge

Dr Cory Willis is a researcher at the University of Cambridge. He told us about his research into astrocytes and how studying these cells could help find new treatments for people with progressive MS.

15/02/2024

Patient #2 of the randomised 👏👏👏

05/02/2024

Absolutely delightful conversation on science facts & figures, but also on expectations with theMSguide.com | Podcast here available

https://shows.acast.com/65731dd80a01ad001247ac9d/65be2af3863949001614e373

Prof Plucino helps set understanding and expectations for MS patients. PLUS: How to get involved in Clinical Trials

30/01/2024

Delighted to share an online book written by one of our patients about his meeting with Stephen Hawking in 2008 and describing how he is still an inspiration of resilience in adversity.
Hoping readings like this to be inspiring to people with disabilities

An Artist' View