Journal of Cell Science

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Journal of Cell Science

JCS publishes research and review-style articles that cover the complete range of topics in cell biology. More info: http://jcs.biologists.org/

10/09/2025

New JCS snapshot - Cytotoxic T lymphocytes adapt to the loss of Cdc42

Adam Rochussen presents the key findings from their recent JCS paper with Claire Ma and Gillian Griffiths.
https://journals.biologists.com/jcs/article/138/15/jcs263826/368784/Transcriptional-adaptation-after-deletion-of-Cdc42

03/09/2025

Issue 16 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/16

Our cover image is a scanning electron micrograph showing macrophages after engulfing IgG-coated beads to their maximal capacity. See article from Fountain et al.

https://journals.biologists.com/jcs/article/138/16/jcs263539/368999/Depletion-of-endomembrane-reservoirs-drives

Also in Issue 16:
- Research Highlights on phagocytosis, tight junctions and mitoribosomes
- Signalling and actin waves at a glance
- Hypothesis on energy deprivation in youth and old age

18/08/2025

Issue 15 is complete

On the cover: 3D electron tomogram model of Trypanosoma cruzi showing the contractile vacuole complex (blue) with an adhesion plaque domain (red) & a membrane fusion pore. See article by Augusto et al.
https://journals.biologists.com/jcs/article/138/15/jcs263810/368816/The-adhesion-plaque-mediates-fluid-discharge-and

Also in Issue 15:
- Research Highlights on collective migration, CTLs & adhesion plaques
- Interview with Ian Ganley
- Essay from Martin Schwartz
- Opinion article on mechanosensitive ion channels
- Review on lipid transfer protein dimerisation

Explore our ToC: https://journals.biologists.com/jcs/issue/138/15

05/08/2025

Issue 14 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/14

Our cover image shows activated primary T cells migrating on an ICAM-1-coated surface. F-actin is shown in cyan, phosphorylated myosin light chain in a yellow heat map, and the nucleus is in grey. See article by Kurtz et al.
https://journals.biologists.com/jcs/article/138/14/jcs263792/368616/The-scaffold-protein-CasL-restrains-membrane

Also in Issue 14:
- Research Highlights on COG and T cell migration
- Interview with Helen Weaver
- Opinion article on α-tubulin K40 acetylation
- MARylation Review

17/07/2025

Issue 13 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/13

Our cover image shows an entire Drosophila midgut folded into a heart shape, with DNA in magenta, Lgl in blue and MARCM-induced mutant clones in yellow. See article by Carvalho et al.

https://journals.biologists.com/jcs/article/138/13/jcs263644/368540/Adherens-junctions-limit-septate-junction-length

Also in Issue 13:
- Research Highlights on scAb-AID2, MatriCom data mining tool, adherens junctions and CDK1-cyclin complexes
- Interview with Angelika Harbauer
- Perspective on functional residuomics
- Review on mitochondrial topoisomerases

03/07/2025

Issue 12 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/12

Our cover image highlights contact sites in A549 cells stably expressing RFFL–EGFP (cyan) and labelled for mitochondria (orange) and lipid droplets (green). See article by Narendradev et al.

https://journals.biologists.com/jcs/article/138/12/jcs263830/368334/Endosomal-RFFL-ubiquitin-ligase-regulates

Also in Issue 12:
- Research Highlights on mitochondrial dynamics and PAKs
- Phagocytosis at a glance poster and review
- Let’s Review II from Mole

18/06/2025

Issue 11 is complete

Explore our ToC here: https://journals.biologists.com/jcs/issue/138/11

Our cover image is a HUVEC monolayer stained for DNA (yellow), VE-cadherin (cyan) and F-actin (magenta). See article by Grönloh et al.
https://journals.biologists.com/jcs/article/138/11/jcs263862/368303/Leukocyte-transendothelial-migration-hotspots-at-a

Also in Issue 11:
- Research Highlights on stress granule formation and a Rab27 auxin-inducible inhibition system
- Leukocyte transendothelial migration hotspots at a glance
- Hypothesis proposing that ancestral eukaryotes sexually proliferated without kinetochores or mitosis

12/06/2025

Our publisher, The Company of Biologists, has been supporting biologists and inspiring biology for 100 years and publishing is still at the heart of what we do. For us to shape the next 100 years and to keep offering a publishing experience that truly supports our community, we are in the process of gathering feedback from our readers, authors and reviewers. Please have your say by completing our community survey at: https://www.surveymonkey.com/r/39QNKHH

02/06/2025

Issue 10 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/10

Our cover image shows a Methylene Blue-stained transverse section of the dorsal thorax of a Drosophila pupa, highlighting adipocytes (brown), hemolymph (grey), hemocytes (magenta), epidermis (green) and other tissues (blue). See article by Andrieu et al. https://journals.biologists.com/jcs/article/138/10/jcs263787/368044/Cell-deformations-generated-by-stochastic

Also in Issue 10:
- 7 Research Highlights
- Cell Scientist to Watch interview with Francesca Bottanelli
- Perspective article on resolution in super-resolution microscopy
- Let’s review I from Mole
https://journals.biologists.com/jcs/issue/138/10

15/05/2025

Our Special Issue: Cell Biology of Mitochondria is complete.

Explore our ToC: https://journals.biologists.com/jcs/issue/138/9

Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
https://journals.biologists.com/jcs/article/138/9/jcs263459/365439/Fis1-regulates-mitochondrial-morphology

Also in this Issue:
- Editorial from Ana Garcia-Saez & Heidi McBride
- Interviews with Tom MacVicar, Samantha Lewis & Heidi McBride
- Mitochondria–membranous organelles contacts at a glance
- Quality control of un-imported mitochondrial proteins at a glance
- Mitochondrial cholesterol transport Perspective
- Mitochondria – the CEO of the cell
Reviews on:
- The role of mitochondrial mRNA translation in cellular communication
- Origin & evolution of mitochondrial IM composition
- Mitochondrial fission – changing perspectives for future progress
https://journals.biologists.com/jcs/issue/138/9

02/05/2025

Issue 8 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/8

Our cover image is an A. flagrans trap with cell-end marker proteins in green & cell walls in blue. These traps are adhesive and attract nematodes. See article by Kriegler et al.
https://journals.biologists.com/jcs/article/138/8/jcs263744/367764/Cell-end-marker-proteins-are-required-for-hyphal

Also in Issue 8:
- Research Highlights on tracking leukocytes, trap formation and pluripotency transitions
- Interview with .bsky.social
- In memoriam – Angelika Noegel
- Epithelial cell extrusion at a glance

17/04/2025

Issue 7 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/7

Our cover image shows the musculature (turquoise, F-actin stained with phalloidin) and tendon cells (red, F-actin labelled by antibody staining of tendon cell-driven F-tractin–RFP) of a formin 3 mutant third-instar Drosophila larva. See article by Pissarek et al.
https://journals.biologists.com/jcs/article/138/7/jcs263543/367667/Formin-3-stabilizes-the-cytoskeleton-of-Drosophila

Also in Issue 7:
- Research Highlights on ATG9A INVs, airway epithelia and Formin 3
- JCS–David Stephens Prize
- Remembering David Stephens (1971–2024)
- Interview with Emmanuel Derivery
- Regulation of cell migration by ECM mechanics at a glance
- Guidelines for data exploration in quantitative cell biology

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