11/04/2026
Clinical takeaway for MLD therapists: this 2025 case report is a useful reminder not to let “average pathways” replace clinical reasoning. In this patient with breast cancer-related lymphoedema, ICG lymphography later confirmed an alternative drainage route that aligned with the traditional redirection work already being used in therapy and self-management. The paper argues that, where patient-specific imaging is not available, abandoning traditional redirecting techniques too early may mean missing a viable compensatory pathway. (MDPI)
For therapists, the message is not “this proves every redirection works”. It is: anatomy varies, drainage routes can differ between patients, and one-size-fits-all protocols may oversimplify what is actually happening in front of us. This was a single case report, so it cannot prove causation, but it does support a personalised, thoughtful approach rather than blindly following generalised imaging trends. (MDPI)
What this means in clinic:
• assess the individual, not just the diagnosis
• be cautious about assuming the ipsilateral axilla is always the only useful route
• value symptom history, tissue presentation, and response to treatment
• keep self-management teaching consistent with your clinical reasoning
• remember that absence of imaging does not mean absence of alternative pathways (MDPI)
For MLD therapists, this is really about preserving good judgement: clear proximally first, then work the target area, keeping the proximal pathways open throughout — while remaining open to the fact that compensatory drainage may be more individual than simplified protocols suggest.
This is based on Wakefield et al., published 6 May 2025 in Reports, a single case report on ICG-confirmed alternative lymph drainage after long-term conservative therapy. 
Background and Clinical Significance: Breast cancer-related lymphedema (BCRL) is a chronic condition affecting up to 20% of breast cancer survivors. Manual lymphatic drainage (MLD) has traditionally included techniques to redirect lymph flow toward alternative pathways when axillary drainage is impa...