Bespoke Cbd UK Ltd

28/02/2026

***research and educational purposes only***

If your struggling with addiction we would highly recommend you go to visit a doctor or therapist.

Neuropharmacologists at Johns Hopkins and the University of California Davis have completed the first rigorous clinical trial of 5-MeO-DMT

The psychedelic compound secreted by the Sonoran Desert toad (Incilius alvarius) — in patients with treatment-resistant opioid, alcohol, and methamphetamine use disorder, finding that a single supervised session produced complete abstinence in 68% of participants at 12-month follow-up, with neural imaging revealing permanent structural remodeling of the nucleus accumbens and anterior cingulate cortex — the brain regions central to addiction circuitry.

One session. One year. Most people free. 🧠
5-MeO-DMT is the most potent naturally occurring psychedelic compound known, producing an intense but brief (15-45 minute) experience of complete ego dissolution — a state in which the default mode network (the brain's self-referential "narrator") goes entirely offline.

During this window, the brain enters a state of hyperplasticity: synaptic connections throughout the cortex and limbic system restructure at extraordinary rates. The neural pathways encoding addiction — the craving associations, the stress-trigger links, the dopaminergic reward loops — are disrupted and rebuilt in patterns that researchers describe as resembling a "factory reset" of the reward system.

The addiction crisis context gives these results extraordinary urgency. Over 100,000 Americans died of drug overdose in 2023. Current addiction treatments — methadone, buprenorphine, naltrexone — manage opioid dependence but rarely resolve it, requiring indefinite daily dosing and offering no path to abstinence for most patients.

A single-session biological reset that produces 68% 12-month abstinence outperforms every current treatment modality by a factor of three or more.
Johns Hopkins has received DEA Schedule I research exemption for expanded trials. Oregon and Colorado are already developing regulatory frameworks for clinical toad compound delivery. The most powerful addiction medicine may come from an amphibian.
Source: Johns Hopkins Psychedelic Research Unit / UC Davis, Nature Medicine 2025

21/02/2026

The body's endocannabinoid system may be the key.

Cannabinoids mimic molecules the body produces naturally and can bind to receptors on cancer cells.
In laboratory settings, this interaction blocked cell growth, starved tumors of blood supply, and commanded programmed cell death.

In a glioblastoma trial, patients treated with cannabis-based medicine alongside chemotherapy saw 83% survival at one year versus 44% with placebo.
Street cannabis is not a substitute for clinical-grade treatments. But the findings mark a critical step forward.

*****Source: Cancer Research UK*****

13/02/2026

Memories hoping to help even more people this year

This is going to be a blessed year

13/02/2026

CBD works with your body — not against it.
Inside us all is something called the endocannabinoid system. Its job? Balance. Regulation. Homeostasis.
When stress, inflammation, poor diet or anxiety knock us out of sync, that balance gets disrupted.

That’s where CBD comes in.
CBD supports your body’s natural ability to restore equilibrium.

Struggling to sleep?
CBD may help calm an overactive mind and regulate your sleep-wake cycle.

Having digestive issues or difficulty going to the toilet?
CBD interacts with receptors in the gut, helping to regulate inflammation and bowel movement.

Living with pain?
CBD may reduce inflammation and support how your nervous system processes pain signals.

It’s not about masking symptoms.
It’s about supporting your body so it can do what it’s designed to do — rebalance itself.
When the body is in homeostasis, everything functions better.
Sleep improves. Digestion flows. Pain eases. Mood stabilises.
Balance is power🍁☺️

01/02/2026

I've had a lot of people messaging, especially since Christmas about feeling unworthy, depressed, low mood , no motivation and here's why
English winters really test the mind🤯

Dark mornings.
Dark nights.
Grey skies on loop.
Less sunlight = low energy, low mood, motivation on mute.
For a lot of people, that seasonal slump turns into real depression.
If winter’s weighing heavy, it’s not weakness — it’s chemistry + climate. Look after your head. Check your people. The light always comes back. 🌤️🔥Winter is nature’s deep breath. It’s the season of slowing down, restoring energy, and quietly rebuilding beneath the surface. Roots strengthen, the ground rests, and everything prepares without rushing. ❄️
Spring is the release. All that recovery turns into regrowth—fresh shoots, new ideas, renewed momentum. What was nurtured in stillness rises with purpose. 🌱
Same rhythm for us: rest, regroup, then rise.

Winter is nature’s deep breath. It’s the season of slowing down, restoring energy, and quietly rebuilding beneath the surface. Roots strengthen, the ground rests, and everything prepares without rushing. ❄️
Spring is the release. All that recovery turns into regrowth—fresh shoots, new ideas, renewed momentum. What was nurtured in stillness rises with purpose. 🌱
Same rhythm for us: rest, regroup, then rise.

16/01/2026

If you have cancer, build up a short intense bout of exercise into your day. Just 10 minutes of hard workout releases molecules into the bloodstream that switch on DNA repair and shut down cancer growth signals.

Researchers at Newcastle University discovered that exercise raises the levels of several small molecules in the blood that reduce inflammation, support healthy blood vessels, and improve metabolism.

When they exposed bowel cancer cells in the lab to blood containing these exercise-driven molecules, they observed widespread genetic changes. More than 1,300 genes shifted their activity, including genes involved in DNA repair, energy production, and cancer cell growth.

Although it’s great to do intense exercise every day, the researchers discovered that even one 10-minute workout started to trigger the healing process.

But it’s not just for people who have cancer. The researchers reckon that any activity—such as walking or biking or doing the gardening—reduces the risk of bowel cancer by around 20 percent. While their focus has been on bowel cancer, it’s likely that exercise will have a similar positive impact on other cancers, too

12/01/2026

Few historic and fun facts on cannabinoids for research and educational purposes 😆

The World's Oldest "Vipers": Around 2,500 years ago, mourners in the Pamir Mountains of western China were already using cannabis. They burned the plants in wooden braziers during burial ceremonies, possibly to "communicate" with the deceased.

The First Medical Record: In 2737 B.C., the Chinese Emperor Shen Nung, often called the father of Chinese medicine, was the first to document the plant’s medicinal uses in his pharmacopeia.

The Scythian "Sauna": Around 450 B.C., the Greek historian Herodotus described the Scythians—nomadic warriors—throwing cannabis seeds onto red-hot stones inside felt tents to create a psychoactive steam bath that made them "shout for joy".

Surprising Historical Facts
The First Online Sale: Long before eBay or Amazon, the first-ever e-commerce transaction was a cannabis deal. In the early 1970s, students at Stanford University used ARPANET (the precursor to the internet) to arrange a purchase with students at MIT.
The Original "Canvas": The word "canvas" actually derives from the word "cannabis". For centuries, h**p was the go-to material for high-strength sails and ropes that powered the global age of exploration.
Founding Farmers: In 1619, the Virginia Assembly passed a law requiring every farmer to grow h**p. Early U.S. leaders like George Washington and Thomas Jefferson were active h**p farmers, using it for everything from fishing nets to clothing.

Cultural Oddities
Easter Island Mystery: One theory suggests the massive statues on Easter Island were "walked" into place using heavy h**p ropes and a rocking motion, rather than being rolled on logs.
The 420 Legend: The term "420" didn't start with a police code; it was a secret meeting time (4:20 p.m.) for a group of San Rafael High School students in 1971 who met by a statue of Louis Pasteur to search for a "lost" cannabis crop.
Royal Relief: Queen Victoria’s personal physician reportedly prescribed her cannabis to help alleviate menstrual cramps.

09/01/2026

A lot of people have been poorly lately , flu, colds , weak , lethargic

I too was feeling unwell, I focused on the basics that help the body recover naturally and safely. Here’s what I done:

1. Rested properly
Your body heals when you rest. I’d slowed down, slept more, and avoided pushing through fatigue, missed the gym and only walked the dog on shorter walks

2. Hydrateed well
Water with a touch of lemon, ginger and herbal teas, they help prevent dehydration and support recovery – especially if you have a fever or cold.

3. Eat simple, nourishing food
Things like:
Soup or broth
Eggs, rice, oats
Fruit (especially oranges, berries, bananas)
Veg like carrots, spinach, and potatoes
Nothing too heavy or greasy.

4. Support the immune system
I’d make sure I was getting:
Vitamin C (fruit, veg)
Vitamin D (supplement in the UK, especially in winter) I had big doses 50000iu per day
Zinc (eggs, meat, seeds)

5. Manage symptoms
Sore throat → warm drinks, honey & lemon
Congestion → steam inhalation
Aches/fever → paracetamol (if safe for you)
I used a herbal remedy 😆

6. Fresh air & gentle movement
If I felt up to it, a short walk or opening windows helps circulation and mood.

7. Listen to my body
If symptoms had worsened, lasted more than a few days, or included chest pain, high fever, or breathing problems, I’d of contacted a GP or NHS 111.

08/01/2026

For research and educational benefits only 🙏

Key Potential Benefits of RSO

Chronic Pain Relief: One of the most common uses for RSO is managing persistent, severe pain from conditions like arthritis, neuropathy, and fibromyalgia.

Cancer Symptom Support: Many patients use RSO to help with chemotherapy-related side effects, such as nausea, vomiting, and loss of appetite.

Sleep and Insomnia: Due to its high THC content and often indica-heavy profile, RSO is frequently used as a powerful sedative to help with deep, restorative sleep.

Anti-Inflammatory Properties: The full spectrum of compounds in RSO may help reduce systemic inflammation, benefiting those with conditions like multiple sclerosis (MS) or inflammatory bowel disease (IBD).

Mental Health Support: In low, controlled doses, some users find RSO effective for reducing symptoms of anxiety and depression.

Neurological Protection: Emerging research suggests RSO may assist in managing seizures and supporting overall neurological health.

Safe Usage Tips for 2026

Start Small: Because RSO is extremely potent (often 60–90% THC), the standard starting dose is a tiny drop about the size of half a grain of rice.

Method of Use: It can be taken sublingually (under the tongue), mixed into food (like peanut butter), or applied topically to the skin.