22/10/2025
People pleasing can trigger an autoimmune condition by causing chronic psychological stress, which leads to inflammation and immune system dysregulation.
To elaborate, chronic people-pleasing creates long-term psychological stress through a consistent pattern behavior:
📑Emotional repression: Repressing emotions like anger, frustration, and sadness to keep others happy increases internal stress.
📑Neglect of self: Prioritizing others’ needs over your own well-being leads to burnout, exhaustion, and chronic anxiety.
📑Lack of boundaries: The inability to say “no” or set limits leads to overcommitment and resentment.
📑Fear of rejection: A constant need for external validation and the anxiety of disappointing others adds to the persistent psychological pressure.
This chronic state of stress disrupts the immune system’s delicate balance through several physiological pathways:
📑Hormonal imbalance: The body’s fight or flight response releases high levels of stress hormones like cortisol and adrenaline. While acute boosts can be helpful, chronic elevation impairs the immune system’s regulation.
📑Inflammation: Prolonged stress leads to a state of chronic inflammation. This happens when the immune system’s response to cortisol becomes blunted, leaving fewer anti-inflammatory effects to balance the inflammatory responses.
📑Immune dysfunction: Over time, the immune system becomes dysregulated and “confused”. Instead of fighting external threats, it begins to attack the body’s own healthy tissues, which is the hallmark of an autoimmune disease.
SOURCE: https://www.mssupportfoundation.org/chronic-stress-and-autoimmune-diseases/
See also PMID: 32983091