
29/09/2025
Today is World Heart Day and Professor George Baillie discusses his teams current research focus.
The Baillie lab is developing novel therapies for heart disease that are more targeted than current treatments which tend to target systemically one enzyme or receptor that can have multiple functions in the cardiovascular system and other tissues. Alternatively, we target single cardiac protein complexes by mapping protein-protein interactions and we use this information to develop disruptor molecules that displace only a fraction of the global pool of one disease causing protein. This displacement strategy has advantages as it only affects a minute percentage of any specific protein that is highly localised within cardiac myocytes and there is no inhibition of its other functions. In this way we can manipulate cell signalling systems in one cellular "nano-domain" that positively regulates cardiac contractility or protects against maladaptions such as cardiac hypertrophy or fibrosis.