23/04/2026
Research shows that the gut microbiome, particularly a subset known as the oestrobolome (the collection of bacteria involved in oestrogen metabolism) plays a critical role in regulating circulating oestrogen levels. These microbes produce enzymes such as β-glucuronidase, which influence how oestrogen is reactivated and recirculated in the body.
As oestrogen levels decline during menopause, studies have observed:
• Reduced microbial diversity
• Shifts in key bacterial populations
• Altered short-chain fatty acid production, impacting gut barrier integrity and inflammation
These changes are associated with:
-Increased intestinal permeability (leaky gut)
-Low-grade systemic inflammation
-Changes in lipid metabolism and insulin sensitivity
-Effects on the gut–brain axis, influencing mood and cognition
There is also emerging evidence that the gut microbiome interacts with:
-The HPA axis (stress response)
-Bone metabolism (via immune and inflammatory pathways)
-Energy balance and adiposity
At Taymount Clinic, we use microbiome analysis to understand how these shifts may be influencing your symptoms. From there, we design personalised interventions to support microbial diversity, metabolic function, and overall resilience during menopause.
Supporting the microbiome isn’t just supportive care, it’s a key part of the physiology of healthy ageing.
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