Fivescore Labs, 7 Bell Yard, London (2025)

20/07/2025

Ca-AKG: A Powerful Ally for Longevity
Ca-AKG (Calcium Alpha-Ketoglutarate) is gaining significant attention regarding its
potential to support healthy aging. It helps maintain cellular energy, reduce inflammation,
and promote longevity as our cells slow down with age.
Ca-AKG is a calcium salt of alpha-ketoglutarate (AKG), vital for energy production in cells. As
plasma AKG levels decline with age, supplementing with Ca-AKG may help replenish them,
supporting cellular energy and slowing aging.
Mitochondria are your cells’ powerhouses, but their function declines with age, leading to
fatigue and slower repair. Ca-AKG may boost mitochondrial function, improving energy
production and promoting a longer healthspan and lifespan .
Chronic inflammation accelerates aging and contributes to diseases like heart disease and
Alzheimer’s. Ca-AKG helps lower inflammatory markers, protecting cells and supporting
immune function .
Ca-AKG is studied for its potential to enhance autophagy, aiding in the removal of damaged
cells and supporting DNA repair. This “cellular cleanup” helps protect against aging and
maintains genetic integrity .
A study published in Cell Metabolism showed that Ca-AKG supplementation extended
lifespan by up to 50% in certain animal models (Chin et al., 2014). By improving
mitochondrial function, reducing inflammation, and supporting DNA repair, Ca-AKG may
offer a multi-faceted approach to healthy aging.
Ca-AKG is available as a supplement and can be easily added to your daily regimen. It’s a
natural way to support your body’s cellular energy production, combat inflammation, and
slow down the effects of aging .

30/06/2025

Ca-AKG: A Powerful Ally for Longevity

Ca-AKG (Calcium Alpha-Ketoglutarate) is gaining significant attention regarding its potential to support healthy aging. It helps maintain cellular energy, reduce inflammation, and promote longevity as our cells slow down with age.
Ca-AKG is a calcium salt of alpha-ketoglutarate (AKG), vital for energy production in cells. As plasma AKG levels decline with age, supplementing with Ca-AKG may help replenish them, supporting cellular energy and slowing aging.
Mitochondria are your cells' powerhouses, but their function declines with age, leading to fatigue and slower repair. Ca-AKG may boost mitochondrial function, improving energy production and promoting a longer healthspan and lifespan .
Chronic inflammation accelerates aging and contributes to diseases like heart disease and Alzheimer's. Ca-AKG helps lower inflammatory markers, protecting cells and supporting immune function .
Ca-AKG is studied for its potential to enhance autophagy, aiding in the removal of damaged cells and supporting DNA repair. This “cellular cleanup” helps protect against aging and maintains genetic integrity .
A study published in Cell Metabolism showed that Ca-AKG supplementation extended lifespan by up to 50% in certain animal models (Chin et al., 2014). By improving mitochondrial function, reducing inflammation, and supporting DNA repair, Ca-AKG may offer a multi-faceted approach to healthy aging.
Ca-AKG is available as a supplement and can be easily added to your daily regimen. It’s a natural way to support your body’s cellular energy production, combat inflammation, and slow down the effects of aging .

27/06/2025

Zinc-Rich Foods: The Key to Longevity & Immune Strength

Zinc is a vital nutrient for longevity, essential for immune defense, DNA repair, and inflammation control . Since the body doesn’t store zinc, daily intake is crucial for strong immunity , efficient cell regeneration , and reduced inflammation , which lowers the risk of heart disease and neurodegeneration. Zinc also enhances brain function , improving cognition and memory, while balancing hormones and promoting skin health by supporting testosterone, insulin, and collagen production.
To maintain optimal zinc levels, incorporate oysters , the richest natural source, or plant-based options like pumpkin seeds , chickpeas, and lentils . Grass-fed beef and lamb provide highly bioavailable zinc, while cashews and almonds offer a combination of zinc and heart-healthy fats. Dark chocolate adds a delicious polyphenol boost, and eggs serve as a complete source of essential nutrients. Research in The American Journal of Clinical Nutrition confirms that adequate zinc intake reduces inflammation and strengthens immune function, while Nature Reviews Immunology links zinc deficiency to accelerated aging . Fuel your body with zinc-rich foods for lifelong health and resilience!

21/06/2025

Beets & Beet Juice: The Longevity Superfood

Beets are a powerhouse superfood packed with nitrates, antioxidants, and TMG (Trimethylglycine), making them essential for heart health, brain function, and DNA repair . Whether eaten whole or enjoyed as beet juice, they enhance circulation by converting nitrates into nitric oxide, which relaxes blood vessels and lowers blood pressure . Beets also support methylation, a key process for detoxification and gene regulation, while improving oxygen delivery to the brain for sharper cognition. Their betaine content aids liver detox, reduces inflammation, and supports fat metabolism, while their impact on mitochondrial function boosts energy and endurance.
Incorporating beets into your diet is easy—drink beet juice for better circulation and stamina, enjoy them roasted or raw for fiber and antioxidants, or blend them into smoothies with greens and ginger for an extra nutrient boost. Pairing them with healthy fats enhances antioxidant absorption. Research in The Journal of Nutrition confirms that TMG from beets improves methylation, lowers homocysteine, and protects cardiovascular health . Fuel your body with beets for detoxification, heart support, and a longer, healthier life!

18/06/2025

Telomeres: The Key to Slowing Aging & Extending Lifespan

Telomeres are the protective caps at the ends of your DNA, acting as a biological clock that determines how long your cells stay healthy . As they shorten, aging accelerates, increasing the risk of disease and cellular decline. Protecting telomeres helps delay cell damage , lower the risk of heart disease and neurodegeneration , and boost energy by supporting mitochondrial function. Longer telomeres also enhance DNA stability , preventing chromosome mutations that drive aging.
To maintain telomere length, adopt a nutrient-rich diet with polyphenols, omega-3s, and antioxidants to reduce oxidative stress. Exercise regularly , prioritize quality sleep , and manage stress through mindfulness. Longevity supplements like Resveratrol, NMN, and vitamin D support telomere health, while intermittent fasting activates telomerase, an enzyme that repairs telomeres. Avoiding toxins and processed foods further protects against oxidative damage. Research in The Lancet shows that longer telomeres reduce the risk of age-related diseases, while Nature Communications confirms that lifestyle choices can slow cellular aging . Invest in your telomeres today for a longer, healthier life!

15/06/2025

Boost Your Longevity with GlyNAC

When it comes to extending healthspan and promoting healthy aging, GlyNAC supplementation is gaining attention for its powerful benefits.
GlyNAC combines glycine and N-acetylcysteine (NAC), two amino acids that work together to boost glutathione, the body’s most important antioxidant. Glutathione plays a critical role in defending your cells from oxidative stress, which is a major contributor to aging and age-related diseases .
As we age, glutathione levels decline, leading to increased cellular damage and inflammation. By supplementing with GlyNAC, you can replenish glutathione levels and support better cellular function and repair.
Improved Mitochondrial Function: Mitochondria are the powerhouses of your cells, and their function tends to decline with age, leading to fatigue and reduced energy. GlyNAC has been shown to improve mitochondrial function, helping your cells produce energy more efficiently and combat aging .
Reduction in Inflammation: Chronic inflammation accelerates aging and contributes to diseases like heart disease, diabetes, and cognitive decline. GlyNAC helps reduce systemic inflammation by boosting glutathione levels, supporting a healthier immune response .
Cognitive Benefits: GlyNAC supplementation has also been linked to improved brain function and cognitive performance. By reducing oxidative stress in neurons, it protects your brain from age-related cognitive decline .
A recent study found that older adults who took GlyNAC for 24 weeks showed significant improvements in muscle strength, cognitive function, and mitochondrial health. These findings suggest that GlyNAC is a promising supplement for supporting longevity and healthy aging (Sekhar et al., 2021).
Adding GlyNAC to your supplement routine can help you stay vibrant, energized, and youthful as you age .

12/06/2025

Saunas: The Heat Therapy That Extends Lifespan

Saunas aren’t just for relaxation—they’re a powerful longevity tool that activates heat shock proteins , repairs damaged cells, and supports mitochondrial health . Regular sauna use improves cardiovascular function by boosting circulation, lowering blood pressure, and reducing mortality risk. It also helps detoxify the body , flushing out toxins and heavy metals while reducing inflammation. Brain health gets a boost, too, as saunas increase BDNF, improving memory and lowering dementia risk. Plus, they mimic the effects of exercise by increasing heart rate, enhancing insulin sensitivity, and supporting fat metabolism.
To maximize sauna benefits, start with 10-15 minute sessions and gradually build up to 20-30 minutes, 4-7 times per week. Stay hydrated , pair with cold therapy for enhanced circulation, and consider infrared saunas for deeper detoxification. Using a sauna post-workout can also speed up recovery and reduce inflammation. Research in JAMA Internal Medicine shows that frequent sauna use can lower all-cause mortality by up to 40%, while Age and Ageing highlights its benefits for heart health and cellular resilience . Ready to sweat your way to a longer, healthier life?

09/06/2025

Omega-3s: The Essential Fat for Longevity & Healthy Aging

Omega-3s are essential fats that play a vital role in longevity, supporting heart health, brain function, and cellular repair . Since your body can’t produce them, you need to get these powerful fats from your diet or supplements to reduce inflammation , lower disease risk, and promote healthy aging . DHA and EPA protect against oxidative stress, support memory and cognition , and reduce the risk of Alzheimer’s. They also enhance heart health by lowering triglycerides and blood pressure, while strengthening joints and muscles for better mobility and recovery. Omega-3s even support DNA integrity by protecting telomeres, key markers of longevity.
To get enough Omega-3s, prioritize fatty fish like salmon, sardines, and mackerel , or opt for plant-based sources such as flaxseeds, chia seeds, and walnuts. High-quality supplements , like fish oil or algae-based Omega-3s, can also help. Research in The American Journal of Clinical Nutrition found that higher Omega-3 levels correlate with a 5-year increase in life expectancy, while Circulation studies confirm their role in reducing heart disease and cognitive decline . Getting enough Omega-3s is a simple yet powerful way to protect your health and extend your lifespan!

06/06/2025

GlyNAC: The Antioxidant Powerhouse for Longevity

GlyNAC, a combination of Glycine and NAC (N-Acetyl Cysteine), is a powerful longevity supplement that boosts glutathione , the body's master antioxidant, while enhancing mitochondrial function and cellular repair. By reducing oxidative stress and chronic inflammation, GlyNAC helps slow aging, protect against free radical damage, and support metabolic efficiency. It also enhances brain function , improving memory and neuron health, while regulating insulin sensitivity to support glucose balance and overall metabolic health .
To maximize its benefits, take GlyNAC as a supplement (1000-2000 mg NAC + 500-1000 mg Glycine daily), or get glycine naturally from foods like bone broth, eggs, and collagen . Pair it with antioxidants like Vitamin C, ALA, and CoQ10, and combine with regular exercise to optimize mitochondrial health. Research in The Journal of Gerontology confirms that GlyNAC supplementation improves glutathione levels, enhances mitochondrial function, and reduces oxidative stress, while Aging Cell links it to better metabolic efficiency and cellular repair . Give your cells the fuel they need for longevity!

03/06/2025

Mitochondria: The Powerhouses of Longevity

Your mitochondria are the powerhouses of your cells, generating ATP to fuel your body and keep you energized . But as you age, mitochondrial function declines, leading to fatigue, slower metabolism, and increased disease risk. Keeping them strong is key to longevity . Healthy mitochondria optimize energy production , reduce oxidative stress , and protect against age-related diseases . They also activate key longevity pathways , enhancing autophagy, AMPK, and sirtuins to slow aging at the cellular level.
To strengthen your mitochondria, focus on a nutrient-dense diet rich in CoQ10, PQQ, resveratrol, and NMN, and engage in regular exercise like HIIT and strength training. Intermittent fasting and ketosis boost mitochondrial efficiency, while cold plunges and saunas strengthen their resilience. Reducing toxins and prioritizing deep sleep are also essential for mitochondrial repair. Research in Nature Aging confirms that improving mitochondrial function extends lifespan, while Cell Metabolism studies show that boosting mitochondrial biogenesis enhances energy, brain health, and longevity . Give your cells the fuel they need to thrive and power up for a longer, healthier life!

26/05/2025

Support Your Longevity with TMG
Trimethylglycine (TMG), also known as betaine, is an essential compound that plays a critical role in promoting methylation, a process that helps your body repair DNA, detoxify harmful substances, and maintain healthy gene expression.
Methylation is vital for many biological processes, and as we age, the efficiency of this process declines. This can lead to increased homocysteine levels, a marker associated with heart disease and other age-related conditions. By donating methyl groups, TMG helps lower homocysteine levels, reducing the risk of cardiovascular diseases and supporting heart health .
TMG is also important for liver health, helping to detoxify the body and support fat metabolism .
By improving detoxification pathways, TMG helps your body eliminate harmful substances more efficiently, contributing to overall longevity.
In addition, TMG supports cellular energy production, helping improve vitality and fight fatigue. This makes it an essential supplement for those looking to maintain energy levels as they age .
One of the lesser-known benefits of TMG is its positive impact on brain health . Proper methylation is essential for neurotransmitter production, and TMG has been shown to support cognitive function and protect against age-related memory loss and cognitive decline .
Studies have shown that TMG supplementation can lower homocysteine levels, supporting cardiovascular and brain health, both of which are crucial for longevity (Steenge et al., 2003). Adding TMG to your supplement regimen is an easy way to protect your heart, brain, and overall health.
Incorporate TMG into your daily routine to promote longevity, improve detoxification, and support healthy aging .

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