Eye Journal

20/11/2025

New research from a nationwide South Korean cohort shows the risk of third, fourth, and sixth cranial nerve palsy rises with worsening glycaemic status. Even impaired fasting glucose increases risk, with the highest rates seen in long-standing diabetes.

https://www.nature.com/articles/s41433-025-04011-w

14/11/2025

We are inviting new editors to join our editorial board and lend their expertise in the following fields:

- Epidemiology
- Orbital and lacrimal disease

Join the Eye team and help advance the science and practice of ophthalmology worldwide

Contact us now for more information or to express your interest.

https://www.nature.com/eye/

12/11/2025

A new study from the University Hospital of Grenoble-Alpes, France, reviewed 33 cases of endogenous endophthalmitis over nine years.

The researchers found that cancer and diabetes were the main risk factors, with endocarditis being the most frequent infection source. Gram-positive bacteria, especially Staphylococcus aureus, were the most common pathogens, and mortality reached 24%.

These findings highlight key differences between European data and reports from the USA and Asia.

Read in full here: https://www.nature.com/articles/s41433-025-04084-7

07/11/2025

JAK inhibitors may help manage difficult cases of noninfectious uveitis. In a series of eight patients treated with tofacitinib or upadacitinib after other therapies failed, most achieved good control of inflammation, side effects were mild, and both drugs were well tolerated. These findings suggest JAK inhibitors could offer an effective treatment option for refractory uveitis.

Read in full here: https://www.nature.com/articles/s41433-025-04065-w

03/11/2025

Keratoconus patients managed non-surgically report considerable declines in quality of life with impacts on both physical and psychological dimensions. A review of 26 studies found that while contact lenses can improve visual function in early disease, they have clear limitations in addressing broader quality of life impacts.

Read : https://www.nature.com/articles/s41433-025-04053-0

30/10/2025

Radiomics is a new specialty that extracts large number of features from medical imaging.

This study developed a predictive model to detect high risk features (optic nerve invasion and choroidal invasion) in intraocular retinoblastoma.

https://www.nature.com/articles/s41433-025-04009-4

27/10/2025

Case series highlights the power of metagenomic next-generation sequencing (mNGS) in diagnosing rare intraocular infections.

From CMV in hyper-IgE syndrome to Bartonella photoreceptoritis and polymicrobial endophthalmitis, mNGS enabled precise pathogen ID and tailored treatment.

Read more here: https://www.nature.com/articles/s41433-025-04073-w

24/10/2025

Have you heard of Transient Neonatal Macular Retinoschisis? New case series explores this intriguing developmental phenomenon in healthy term infants.

TNMR resolves spontaneously and differs from congenital conditions like XLRS. The findings suggest TNMR may reflect normal foveal development and highlight the importance of avoiding misdiagnosis.

Read now: https://www.nature.com/articles/s41433-025-04082-9

To report and characterise a novel observation of ‘transient neonatal macular retinoschisis’ (TNMR) in a series of healthy, term infants, differentiate it from congenital pathologies, such as X-linked retinoschisis (XLRS). This case series reports on five term neonates with incidental macular re...

22/10/2025

New in EYE OPEN

New study explores the impact of public and patient involvement and engagement on sleep and visual impairment. Discover what's known, what's new, and how collaborative research is shaping better outcomes.

Read here: https://www.nature.com/articles/s44440-025-00006-4

21/10/2025

New research on intermediate age-related macular degeneration shows that visual acuity declines only slightly over two years, by an average of ~2 ETDRS letters.

- All subgroups, including those with incomplete retinal pigment epithelium atrophy (iRORA) and subretinal drusenoid deposits (SDD), showed minor changes.

- Increasing age and lower baseline vision were linked to greater decline.

- Importantly, these changes may not be clinically meaningful.

This study adds valuable insight into the progression of iAMD and may help guide patient expectations and monitoring strategies.



Read in full here: https://www.nature.com/articles/s41433-025-04062-z

16/10/2025

20-year review of 338 orbital biopsies at a UK tertiary centre (2004–2023) shows the procedure is safe and effective, with low vision loss (0.3%) and 4.3% complication rate. IgG4 diagnoses increased over time, and risk factors for diplopia were identified.

Read more here: https://www.nature.com/articles/s41433-025-04079-4

14/10/2025

RCOphth 2025 Duke Elder Lecture

Prof Kyoko Ohno-Matsui discusses how early detection of posterior changes is essential to prevent irreversible retinal damage in pathologic myopia. Advancing imaging helps guide timely, targeted intervention

👉 https://www.nature.com/articles/s41433-025-04072-x