Eye Journal

25/09/2025

Can early OCT scans predict glaucoma progression?

A study of 472 eyes shows that the rate of initial cpRNFL thinning, measured over just the first 4–5 OCT visits, can effectively forecast future structural changes in glaucoma patients.

👉 https://www.nature.com/articles/s41433-025-04021-8

24/09/2025

UWFI detects 97% of retinal breaks with steered imaging

Dublin study shows ultra-wide field imaging (UWFI) is a powerful tool for identifying treatment-requiring peripheral retinal breaks, especially temporal & nasal. Still, dilated clinical exam remains essential.


https://www.nature.com/articles/s41433-025-03998-6

22/09/2025

Eye Open invites authors to submit papers on the following subjects:

- Health equity and access to ophthalmic care
- Ophthalmology training – experiences and opportunities
- Advances in imaging

Submit here: https://www.nature.com/eyeopen/

Info: eyeopen@rcophth.ac.uk

22/09/2025

NEW! Explore our latest infographic summarising the results from the Phase II IIH Drug Trial, a landmark study evaluating AZD4017 for idiopathic intracranial hypertension.

Read in full : https://www.nature.com/articles/s41433-025-03973-1

10/09/2025

A stepwise, patient-centred genomic strategy boosts diagnostic yield in inherited retinal dystrophies. Reanalysis with WES, WGS, customised panels & functional assays raised resolution from 59.6% to 67.6%, offering a scalable path to precision medicine in IRDs.

https://www.nature.com/articles/s41433-025-03981-1

08/09/2025

Adaptive optics assessment of hyporeflective clumps suggests a role as a biomarker in . Rapid movement at 0.15um/s was observed, and HRC size was larger in images of atrophy.

https://nature.com/articles/s41433-025-03951-7

Hyporeflective clumps (HRC) are a common finding in adaptive optics ophthalmoscopy (AOO) of age-related macular degeneration (AMD). They appear on optical coherence tomography (OCT) as hyperreflective foci (HRF) or abutting the retinal pigment epithelium (RPE) layer as RPE thickening. The cellular o...

01/09/2025

UK results from 36-month XTEND study show that proactive intravitreal aflibercept treatment for nAMD delivered and maintained meaningful visual and anatomical gains through 24 months, despite challenges of the COVID-19 pandemic.

https://www.nature.com/articles/s41433-024-03550-y

The 36-month XTEND (NCT03939767) multicentre, observational, prospective study examined the effectiveness of proactive treatment regimens of intravitreal aflibercept (IVT-AFL) 2 mg in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) in routine clinical practice. T...

29/08/2025

Since their introduction, the use of large language models (LLMs) have gained widespread interest, especially in the medical field. This review highlights original research articles on how LLM’s can be utilised in .

https://www.nature.com/articles/s41433-025-03935-7

22/08/2025

New study compares traditional methods with smartphone-based tools for measuring orbital implant motility post-enucleation. ImageJ emerges as a reliable alternative to standard rule measurement, enabling more accessible, home-based assessments.

Read here: https://www.nature.com/articles/s41433-025-03936-6

19/08/2025

New in Eye Open: Study compares research output on diabetic retinopathy (DR) vs sickle cell retinopathy (SCR).

Findings: DR dominates publications (69k vs 1k), driven by high-income countries. SCR research lags, with limited contributions from Africa & the Caribbean.

Retinal vascular diseases pose significant challenges to ensuring global ocular health with consequent negative impacts on the well-being of individuals worldwide. This study explores the divergent research landscapes of Sickle Cell Retinopathy (SCR) and Diabetic Retinopathy (DR), two of the most co...

13/08/2025

Myopia is a leading cause of vision impairment worldwide.
This review outlines current and emerging strategies for myopia control, from optical & drug therapies to lifestyle & novel light treatments.

Read here: https://www.nature.com/articles/s41433-025-03949-1

12/08/2025

High success, low recurrence: A prospective study at a Johannesburg eye hospital found that a size-based approach to OSSN treatment (excision for small tumours, topical 5FU for larger) achieved >70% complete resolution and

The aim of this study is to describe the outcomes of OSSN management at a tertiary eye hospital in Johannesburg, South Africa. This was a prospective interventional study, which included patients presenting with conjunctival masses at a tertiary eye hospital from December 2019 to February 2022. An e...