Eye Journal

22/12/2025

SPOTTED: One of Santa’s reindeer observed transiting the macula seen in an en face OCT retinal image 🦌

Many thanks to the team at the Southampton Eye Unit for this festive cover image. 🎄

https://www.nature.com/eye/volumes/39/issues/18

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11/12/2025

From evidence to recommendations, from global to local: Our new editorial introduces ophthalmologists to GRADE EtD & Adolopment frameworks for adapting trustworthy guidelines to context.

Part of the 'Research Methodology for the Ophthalmologist' online collection

https://www.nature.com/articles/s41433-025-04139-9

09/12/2025

New research using the TriNetX network shows that people with ulcerative colitis who also have ocular inflammatory disease face higher risks of intestinal complications, extraintestinal morbidity, rheumatologic disease and cardiovascular events. No increased risk was seen for colorectal cancer or mortality

https://www.nature.com/articles/s41433-025-04151-z

01/12/2025

From idebenone to gene editing and optic nerve regeneration - this review highlights emerging therapies for inherited optic neuropathies and what’s needed to bring them to clinic.

Read here: https://www.nature.com/articles/s41433-025-04109-1

20/11/2025

New research from a nationwide South Korean cohort shows the risk of third, fourth, and sixth cranial nerve palsy rises with worsening glycaemic status. Even impaired fasting glucose increases risk, with the highest rates seen in long-standing diabetes.

https://www.nature.com/articles/s41433-025-04011-w

14/11/2025

We are inviting new editors to join our editorial board and lend their expertise in the following fields:

- Epidemiology
- Orbital and lacrimal disease

Join the Eye team and help advance the science and practice of ophthalmology worldwide

Contact us now for more information or to express your interest.

https://www.nature.com/eye/

12/11/2025

A new study from the University Hospital of Grenoble-Alpes, France, reviewed 33 cases of endogenous endophthalmitis over nine years.

The researchers found that cancer and diabetes were the main risk factors, with endocarditis being the most frequent infection source. Gram-positive bacteria, especially Staphylococcus aureus, were the most common pathogens, and mortality reached 24%.

These findings highlight key differences between European data and reports from the USA and Asia.

Read in full here: https://www.nature.com/articles/s41433-025-04084-7

07/11/2025

JAK inhibitors may help manage difficult cases of noninfectious uveitis. In a series of eight patients treated with tofacitinib or upadacitinib after other therapies failed, most achieved good control of inflammation, side effects were mild, and both drugs were well tolerated. These findings suggest JAK inhibitors could offer an effective treatment option for refractory uveitis.

Read in full here: https://www.nature.com/articles/s41433-025-04065-w

03/11/2025

Keratoconus patients managed non-surgically report considerable declines in quality of life with impacts on both physical and psychological dimensions. A review of 26 studies found that while contact lenses can improve visual function in early disease, they have clear limitations in addressing broader quality of life impacts.

Read : https://www.nature.com/articles/s41433-025-04053-0

30/10/2025

Radiomics is a new specialty that extracts large number of features from medical imaging.

This study developed a predictive model to detect high risk features (optic nerve invasion and choroidal invasion) in intraocular retinoblastoma.

https://www.nature.com/articles/s41433-025-04009-4

27/10/2025

Case series highlights the power of metagenomic next-generation sequencing (mNGS) in diagnosing rare intraocular infections.

From CMV in hyper-IgE syndrome to Bartonella photoreceptoritis and polymicrobial endophthalmitis, mNGS enabled precise pathogen ID and tailored treatment.

Read more here: https://www.nature.com/articles/s41433-025-04073-w

24/10/2025

Have you heard of Transient Neonatal Macular Retinoschisis? New case series explores this intriguing developmental phenomenon in healthy term infants.

TNMR resolves spontaneously and differs from congenital conditions like XLRS. The findings suggest TNMR may reflect normal foveal development and highlight the importance of avoiding misdiagnosis.

Read now: https://www.nature.com/articles/s41433-025-04082-9

To report and characterise a novel observation of ‘transient neonatal macular retinoschisis’ (TNMR) in a series of healthy, term infants, differentiate it from congenital pathologies, such as X-linked retinoschisis (XLRS). This case series reports on five term neonates with incidental macular re...